Effectiveness of Cream from Dadap Serep (Erythrina subumbrans (Hassk.) Merr.) Leaf Extract as Anti- inflammatory
DOI:
https://doi.org/10.36733/medicamento.v9i1.5257Keywords:
cream, dadap serep leave, inflammationAbstract
Inflammation is the mechanism of the body's defense by secreting inflammatory mediators, including bradykinin, prostaglandins, serotonin, and histamine, due to physical or chemical stimuli. Generally, inflammation initiates the body's response to the effect of damaged tissue, for example, in the wound healing process. In Usada Bali, dadap serep leaves were used for wound healing. The design of this study was a randomized control group pretest-posttest design. The anti-inflammatory test of dadap serep leave extract cream used four groups, including KN (negative control), KP (positive control), KF1 (Formula 1 group), and KF2 (Formula 2 group), with a total of 24 rats. Tukey’s analysis showed a significant difference between KN and KP, KF1, and KF2 with significant values (0.031; 0.000; 0.000), respectively. There are significant differences in KP with KF1 and KF2 with significant values (0.050 and 0.021), respectively. In KF1 with KF2, there is no significant difference with the sig value. 0.975. From the research, it can be concluded that the cream of ethanol extract of dadap serep leaves with a concentration of 20% could provide an anti-inflammatory effect in carrageenan-induced rat models.
References
Pramitaningastuti AS, Anggraeny EN. Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Srikaya (Annona squamosa. L) terhadap Edema Kaki Tikus Putih Jantan Galur Wistar. J Ilm Farm. 2017;13(1):8-14.
Katzung BG. Farmakologi Dasar Dan Klinik. Salemba Medika; 2004.
Sukmawati, Yullet, Hardani R. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Pisang Ambon (Musa paradisiaca L.) terhadap Tikus Putih (Rattus norvegicus L.) yang Diinduksi Karagenan. Galen J Pharm. 2015;1(2):126-132.
Andayani D, Suprihartini E, Astuti M. Efek Antiinflamasi Ekstrak Etanol Krokot (Portulaca oleracea, L.) pada Udema Tikus yang di Induksi Karagenin. JPSCR J Pharm Sci Clin Res. 2018;3(1):43. doi:10.20961/jpscr.v3i1.15108
Rahman AA, Firmansyah R, Setyabudi L. Aktivitas Antibakteri Ekstrak Etanol Daun Dadap Serep (Erythrina lithosperma Miq.) Terhadap Pertumbuhan Escherichia coli. Pharmacoscript. Published online 2018.
Mugiyanto E, Slamet, Fatmala R. Karakterisasi Simplisia Dan Ekstrak Anti Piretik Daun Dadap Serep (Erythrina Lithosperma Miq) Dari Kabupaten Pekalongan. J URECOL. Published online 2018.
Suena NMDS, Ariani NLWM, Antari NPU. Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory. J Ilm Medicam. 2022;8(1):22-30. doi:10.36733/medicamento.v8i1.3425
Solihah MA, Rosli WWI, Nurhanan AR. Phytochemicals screening and total phenolic content of Malaysian Zea mays hair extracts. Int Food Res J. 2012;19(4):1533-1538.
Cahyaningsih E, Yuda PESK. Uji Aktivitas Ekstrak Daun Mimba (Azadirachta indica A. Juss) sebagai Bahan Pengawet Alami Buah Tomat. J Ilm Medicam. 2020;6(2):118-122. doi:10.36733/medicamento.v6i2.1108
Maslahat M, Syawaalz A, Restianingsih R. Identifikasi Senyawa Kimia pada Simplisia Daun Sirsak (Annona muricata Linn.). J Sains Nat. 2013;3(1):63-73. doi:10.31938/jsn.v3i1.56
Ramadhani N, Sumiwi SA. Aktivitas antiinflamasi berbagai tanaman diduga berasal dari flavonoid. Farmaka. 2016;Supp. 14(2):111-123.
Luliana S, Susanti R, Agustina E. Uji Aktivitas Antiinflamasi Ekstrak Air Herba Ciplukan (Physalis angulata L.) terhadap Tikus Putih (Rattus norvegicus L.) Jantan Galur Wistar yang Diinduksi Karagenan. Tradit Med J. 2017;22(3):204.
Rukachaisirikul T, Saeke A, Tharibun C, Watkuolham S, Suksamram A. Biological activities of the chemical constituents of Erythrina stricta and Erythrina subumbrans. Arch Pharm Res. 2007;30(1):1398–1403. doi:10.1007/BF02977363
Agustina R, Indrawati D., Masruhin M. Aktivitas Ekstrak Daun Salam (Eugenia poyantha) Sebagai Antiinflamsi Pada Tikus Putih (Rattus norvegicus). J Trop Pharm Chem. 2015;3(2):120-12.
Aria M, Verawati V, Arel A, Monika M. Uji Efek Antiinflamasi Fraksi Daun Piladang (Solenostemonscutellarioides (L.) Codd) terhadap Mencit Putih Betina. Sci J Farm dan Kesehat. 2015;5(2):84. doi:10.36434/scientia.v5i2.27
Winarti L. Uji Antiinflamasi Ekstrak Metanol Daun Sirih Merah Pada Tikus Putih. Majala Obat Tradis. 2011;16(1):34-43.
Hasim, Arifin YY, Andrianto D, Faridah DN. Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi) sebagai Antioksidan dan Antiinflamasi. J Apl Teknol Pangan. 2019;8(3):86. doi:10.17728/jatp.4201
Alemu A, Tamiru W, Nedi T, Shibeshi W. Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models. Evidence-Based Complement Altern Med. Published online 2018:1-8.
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