Interaction Phloroglucinol as inflammation therapy through Cyclooxygenase-2 (COX-2) gene inhibition
DOI:
https://doi.org/10.36733/medicamento.v8i1.3162Keywords:
COX-2, inflammation, natural compound, Phaeophyta, PhloroglucinolAbstract
Exploration of natural compounds is one of the projects in the context of curving disease, one of which is inflammatory therapy in the body, one of the natural ingredients used is Phloroglucinol which has anti-inflammatory properties but there is no information on molecular studies related to its activity. The purpose of this study was to explore the potential of Phloroglucinol as an anti-inflammatory mechanism. Phloroglucinol compound (CID 359) was downloaded from the PubChem Protein COX-2 database (PDB ID 6cox) downloaded from the Protein Data Bank database. The compound Phloroglucinol interacted with the Molegro virtual Docker 5 program with Grid docking X 66,44; Y 27.44; Z 107.23. The docking results were analyzed using Discovery Studio software ver 21.1.1. The results showed that Phloroglucinol binds to five COX-2 amino acid residues and may inhibit COX-2 performance and can be a strong candidate for inflammatory therapy when inflammation occurs. in the human body. The conclusion of this study is that Phloroglucinol compounds have the potential in inhibiting COX-2 (inflammatory mediators).
References
Al-Saeed, A. (2011). Gastrointestinal and Cardiovascular Risk of NonsteroidalAnti-inflammatory Drugs. Oman Medical Journal, 26(6), 385–391. https://doi.org/10.5001/omj.2011.101
Bare, Y. (2021). ANALISIS SENYAWA FITOSTEROL Cymbopogon citratus dan Curcuma longa SEBAGAI ANTIALZHEIMER. Biopendix: Jurnal Biologi, Pendidikan dan terapan, 7(2), 53–159. https://doi.org/10.30598/biopendixvol7issue2page153-159
Bare, Y., Indahsari, L. I. N., Sari, D. R. T., & Watuguly, T. (2021). In Silico Study: Potential Prediction of Curcuma longa And Cymbopogon citratus Essential Oil As Lipoxygenase Inhibitor Yohanes. JSMARTech, 02(02), 76–80. https://doi.org/10.21776/ub.jsmartech.2021.002.02.75 In
Bare, Y., Marhendra, A., Sasase, T., & Fatchiyah, F. (2018). Differential Expression of IL-10 Gene and Protein in Target Tissues of Rattus Norvegicus Strain Wistar Model Type 2 Diabetes Mellitus (T2DM). Acta Informatica Medica, 26(2), 87. https://doi.org/10.5455/aim.2018.26.87-92
Bare, Y., S, M., Putra, S. H. J., L, M. R. W. G., & Sari, D. R. T. (2020). In-silico Approach for The Prediction of Chlorogenic Acid as PPAR-γ Activator. Biota, 13(1). https://doi.org/10.20414/jb.v13i1.197
Bare, Y., Sari, D. R., Rachmad, Y. T., Tiring, S. S. N. D., Rophi, A. H., & Nugraha, F. A. D. (2019). Prediction Potential Chlorogenic Acid As Inhibitor Ace (In Silico Study). Bioscience, 3(2), 197. https://doi.org/10.24036/0201932105856-0-00
Bare, Y., & Sari, D. R. T. (2021). Pengembangan Lembar Kerja Mahasiswa (LKM) Berbasis Inkuiri Pada Materi Interaksi Molekuler. BioEdUIN, 11(1), 8. https://doi.org/10.15575/bioeduin.v11i1.12077
Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D’Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., Usov, A. I., Ustyuzhanina, N. E., Grachev, A. A., Sanderson, C. J., Kelly, M., Rabinovich, G. A., Iacobelli, S., Nifantiev, N. E., & and on behalf of the Consorzio Interuniversitario Nazionale per la Bio-Oncologia (CINBO), I. (2007). A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. Glycobiology, 17(5), 541–552. https://doi.org/10.1093/glycob/cwm014
Dürig, J., Bruhn, T., Zurborn, K.-H., Gutensohn, K., Bruhn, H. D., & Béress, L. (1997). ANTICOAGULANT FUCOIDAN FRACTIONS FROM FUCUS VESICULOSUS INDUCE PLATELET ACTIVATION IN VITRO. Thrombosis Research, 85(6), 479–491. https://doi.org/10.1016/S0049-3848(97)00037-6
El Gamal, A. A. (2010). Biological importance of marine algae. Saudi Pharmaceutical Journal, 18(1), 1–25. https://doi.org/10.1016/j.jsps.2009.12.001
Elfi, T. N., Bunga, Y. N., & Bare, Y. (2021). STUDI AKTIVITAS BIOLOGI SECARA IN SILICO SENYAWA NONIVAMIDE DAN NORDIHYDROCAPSAICIN SEBAGAI ANTI INFLAMASI. Florea : Jurnal Biologi dan Pembelajarannya, 8(2), 82. https://doi.org/10.25273/florea.v8i2.9983
Elshamy, A. I., Mohamed, T. A., Essa, A. F., Abd-Elgawad, A. M., Alqahtani, A. S., Shahat, A. A., Yoneyama, T., Farrag, A. R. H., Noji, M., El-Seedi, H. R., Umeyama, A., Paré, P. W., & Hegazy, M. E. F. (2019). Recent advances in Kaempferia phytochemistry and biological activity: A comprehensive review. In Nutrients (Vol. 11, Issue 10). https://doi.org/10.3390/nu11102396
Freshwater, J. D., Svensson, C. I., Malmberg, A. B., & Calcutt, N. A. (2002). Elevated Spinal Cyclooxygenase and Prostaglandin Release During Hyperalgesia in Diabetic Rats. Diabetes, 51(7), 2249–2255. https://doi.org/10.2337/diabetes.51.7.2249
Galasso, C., Corinaldesi, C., & Sansone, C. (2017). Carotenoids from marine organisms: Biological functions and industrial applications. Antioxidants, 6(4). https://doi.org/10.3390/antiox6040096
Generalić Mekinić, I., Skroza, D., Šimat, V., Hamed, I., Čagalj, M., & Popović Perković, Z. (2019). Phenolic Content of Brown Algae (Pheophyceae) Species: Extraction, Identification, and Quantification. Biomolecules, 9(6), 244. https://doi.org/10.3390/biom9060244
Hakim, M. M., & Patel, I. C. (2020). A review on phytoconstituents of marine brown algae. Future Journal of Pharmaceutical Sciences, 6(1). https://doi.org/10.1186/s43094-020-00147-6
Kang, N. J., Lee, K. W., Shin, B. J., Jung, S. K., Hwang, M. K., Bode, A. M., Heo, Y.-S., Lee, H. J., & Dong, Z. (2008). Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. Carcinogenesis, 30(2), 321–330. https://doi.org/10.1093/carcin/bgn282
Kellogg, A., Pop-Busui, R., & Cheng, H. T. (2008). Cyclooxygenase-2 Pathway as a Potential Therapeutic Target in Diabetic Peripheral Neuropathy. Current Drug Targets, 9(1), 68–76. https://doi.org/10.2174/138945008783431691
Kim, K. C., Piao, M. J., Zheng, J., Yao, C. W., Cha, J. W., Kumara, M. H. S. R., Han, X., Kang, H. K., Lee, N. H., & Hyun, J. W. (2014). Fucodiphlorethol G Purified from Ecklonia cava Suppresses Ultraviolet B Radiation-Induced Oxidative Stress and Cellular Damage. Biomolecules & Therapeutics, 22(4), 301–307. https://doi.org/10.4062/biomolther.2014.044
Knights, K. M., Mangoni, A. A., & Miners, J. O. (2010). Defining the COX inhibitor selectivity of NSAIDs: Implications for understanding toxicity. Expert Review of Clinical Pharmacology, 3(6), 769–776. https://doi.org/10.1586/ecp.10.120
Krisnamurti, G. C., Sari, D. R. T., & Bare, Y. (2021). Capsaicinoids from Capsicum annuum as an Alternative FabH Inhibitor of Mycobacterium Tuberculosis: In Silico Study. Bahan Alam, COX-2, Inflamasi, Phaeophyta, Phloroglucinol, 25(4), 195–202. https://doi.org/10.7454/mss.v25i4.1248
Mao, Q. Q., Xu, X. Y., Cao, S. Y., Gan, R. Y., Corke, H., Beta, T., & Li, H. Bin. (2019). Bioactive compounds and bioactivities of ginger (zingiber officinale roscoe). Foods, 8(6), 1–21. https://doi.org/10.3390/foods8060185
Pradhan, B., Nayak, R., Patra, S., Jit, B. P., Ragusa, A., & Jena, M. (2020). Bioactive Metabolites from Marine Algae as Potent Pharmacophores against Oxidative Stress-Associated Human Diseases: A Comprehensive Review. Molecules (Basel, Switzerland), 26(1). https://doi.org/10.3390/molecules26010037
Rophi, A. H., Bare, Y., & Sari, D. R. T. (2021). The Potential of Acetylfuran and Furfural from Tamarindus indica as Lipoxygenase Inhibitor: In Silico Study. JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA, 8(2), 139. https://doi.org/10.20473/jfiki.v8i22021.139-142
S, M., Bare, Y., Helvina, M., Pili, A. P., & Krisnamurti, G. C. (2020). In silico Study: Potential activity of 10-shogaol in Zingiber officinale through ACE gene. Spizaetus: Jurnal Biologi Dan Pendidikan Biologi, October, 12–18.
Samsi, A. N., & Rusmidin. (2021). Review: Metabolit Sekunder pada Algae. Bioma, 3(1), 6. https://doi.org/10.31605/bioma.v3i1.999
Santoso, B., & Atmajaya, T. E. (2016). KAJIAN DOCKING SENYAWA 4-[(Z)-N-(4-hidroksifenil)carboksimidoil]-2- metoksifenol SEBAGAI INHIBITOR COX-2 MENGGUNAKAN PLANTS. 8.
Sari, D. R. T., & Bare, Y. (2021). Kajian In Silico Aktivitas Antioksidan Senyawa Bioaktif Dalam Minyak Serai (Cymbopogon Citratus). Al-Kimia, 9(1), 61–69.
Tiring, S. S. N. D., Bare, Y., S;, M., Maulidi, A., & Nugraha, F. A. D. (2019). Studi In Silico: Prediksi Potensi 6-shogaol dalam Zingiber officinale sebagai Inhibitor c-Jun N-terminal kinase. Al-Kimia, 7(2), 147–153.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Jurnal Ilmiah Medicamento
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The copyright holder for the work is the Jurnal Ilmiah Medicamento.
Jurnal Ilmiah Medicamento is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
You are free to:
- Share — copy and redistribute the material in any medium or format
- The licensor cannot revoke these freedoms if you follow the license terms.
Under the following terms:
-
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so reasonably but not in any way that suggests the licensor endorses you or your use.
-
NonCommercial — You may not use the material for commercial purposes.
-
NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.