Essential Oil of Alpinia galanga: Effect of Aromatherapy Inhalation in Mice and Physicochemical Characterization

Authors

  • Ni Made Dwi Mara Widyani Nayaka Fakultas Farmasi Universitas Mahasaraswati Denpasar https://orcid.org/0000-0002-7545-0706
  • Ni Luh Putu Swari
  • Putu Era Sandhi Kusuma Yuda
  • I Gusti Ayu Agung Kusuma Wardani

DOI:

https://doi.org/10.36733/medicamento.v8i2.3791

Keywords:

Alpinia galanga, antidepressant, aromatherapy, essential oil, physicochemical characterization

Abstract

Aromatherapy has been used for centuries to maintain body and mental health. In aromatherapy, the inhalation of essential oil provides physical and psychological benefit due to its volatile bioactive compounds. The current study was aimed to determine the effect of the inhalation of Alpinia galanga essential oil in mice using forced swim test. The refractive index, solubility, and Gas Chromatography-Mass Spectrophotometry (GC-MS) profile of AGEO were also investigated. The essential oil from Alpinia galanga showed an anti-depressive-like effect and it was as strong as the positive control (Lavandula angustifolia essential oil). The GC-MS analysis discovered some antidepressant compounds in the oil such as eucalyptol, fenchone, and α-terpineol.

Author Biography

Ni Made Dwi Mara Widyani Nayaka, Fakultas Farmasi Universitas Mahasaraswati Denpasar

Departemen Farmasi Bahan Alam

References

Abbasi-Maleki, S., Kadkhoda, Z., & Taghizad-Farid, R. (2020). The antidepressant-like effects of Origanum majorana essential oil on mice through monoaminergic modulation using the forced swimming test. Journal of Traditional and Complementary Medicine, 10(4), 327–335. https://doi.org/10.1016/j.jtcme.2019.01.003

Anwar, F., Sulman, M., Hussain, A. I., Saari, N., Iqbal, S., & Rashid, U. (2011). Physicochemical composition of hydro-distilled essential oil from coriander (Coriandrum sativum L.) seeds cultivated in Pakistan. Journal of Medicinal Plants Research, 5(15), 3537–3544. http://www.academicjournals.org/JMPR

Assunção, A. F. C., Rodrigues, N. D. S., Sampaio, A. V. da C., Silva, K. dos S., Silva, L. R. da, Martins, M. G. dos S., Almeida, F. R. de C., Lopes, L. da S., Monte, S. M., Marques, R. B., & Maia-Filho, A. L. M. (2021). Alpha-terpineol: evaluation and pharmacological screening as an antidepressant agent. Research, Society and Development, 10(11), e191101119571. https://doi.org/10.33448/rsd-v10i11.19571

Barkatullah, Ibrar, M., Rauf, A., & Rahman, U. I. (2012). Physicochemical characterization of essential and fixed oils of Skimmia laureola and Zanthoxylum armatum. Middle-East Journal of Medicinal Plants Research, 1(3), 51–58. https://www.semanticscholar.org/paper/Physicochemical-Characterization-of-Essential-and-Ibrar/08ff27334f45512806da1cead423627487cc58cc

Baser, K. H. C., & Buchbauer, G. (2016). Handbook of essential oils. Science, Technology, and applications,. In CRSC Press.

Bueno-Notivol, J., Gracia-García, P., Olaya, B., Lasheras, I., López-Antón, R., & Santabárbara, J. (2021). Prevalence of depression during the COVID-19 outbreak: A meta-analysis of community-based studies. International Journal of Clinical and Health Psychology, 21(1). https://doi.org/10.1016/J.IJCHP.2020.07.007

Chioca, L. R., Ferro, M. M., Baretta, I. P., Oliveira, S. M., Silva, C. R., Ferreira, J., Losso, E. M., & Andreatini, R. (2013). Anxiolytic-like effect of lavender essential oil inhalation in mice: Participation of serotonergic but not GABAA/benzodiazepine neurotransmission. Journal of Ethnopharmacology, 147(2), 412–418. https://doi.org/10.1016/j.jep.2013.03.028

Chouni, A., & Paul, S. (2018). A review on phytochemical and pharmacological potential of Alpinia galanga. Pharmacognosy Journal, 10(1), 9–15. https://doi.org/10.5530/PJ.2018.1.2

De-Montijo-Prieto, S., Razola-Díaz, M. del C., Gómez-Caravaca, A. M., Guerra-Hernandez, E. J., Jiménez-Valera, M., Garcia-Villanova, B., Ruiz-Bravo, A., & Verardo, V. (2021). Essential Oils from Fruit and Vegetables, Aromatic Herbs, and Spices: Composition, Antioxidant, and Antimicrobial Activities. Biology 2021, Vol. 10, Page 1091, 10(11), 1091. https://doi.org/10.3390/BIOLOGY10111091

Dhifi, W., Bellili, S., Jazi, S., Bahloul, N., & Mnif, W. (2016). Essential Oils’ Chemical Characterization and Investigation of Some Biological Activities: A Critical Review. Medicines, 3(4), 25. https://doi.org/10.3390/MEDICINES3040025

Dosoky, N. S., & Setzer, W. N. (2018a). Biological activities and safety of citrus spp. Essential oils. In International Journal of Molecular Sciences (Vol. 19, Issue 7). MDPI AG. https://doi.org/10.3390/ijms19071966

Dosoky, N. S., & Setzer, W. N. (2018b). Chemical composition and biological activities of essential oils of curcuma species. In Nutrients (Vol. 10, Issue 9). MDPI AG. https://doi.org/10.3390/nu10091196

Dougnon, G., & Ito, M. (2020). Inhalation Administration of the Bicyclic Ethers 1,8- and 1,4-cineole Prevent Anxiety and Depressive-Like Behaviours in Mice. Molecules 2020, Vol. 25, Page 1884, 25(8), 1884. https://doi.org/10.3390/MOLECULES25081884

Ganesh, V. S., Reddy, K. S., P, R. varma., & Balaraju, J. (2019). In Vivo Assessment of Antidepressant Upshot of L - Fenchone in Chronic Unpredictable Mild Stress (CUMS) Induced Depression Like Behaviour in Rodents. World Journal of Current Medical and Pharmaceutical Research, 1(5), 177–183. https://wjcmpr.com/index.php/journal/article/view/37

Karakaya, S., El, S. N., Karagozlu, N., Sahin, S., Sumnu, G., & Bayramoglu, B. (2012). Microwave-assisted hydrodistillation of essential oil from rosemary. Journal of Food Science and Technology, 51(6), 1056–1065. https://doi.org/10.1007/S13197-011-0610-Y

Khairullah, A. R., Solikhah, T. I., Nur, A., Ansori, M., Fadholly, A., Ramandinianto, S. C., Ansharieta, R., Widodo, A., Hendriana, K., Riwu, P., Putri, N., Proboningrat, A., Khaliim, M., Kusala, J., Rendragraha, B. W., Rozaqi, A., Putra, S., & Anshori, A. (2020). A Review of an Important Medicinal Plant: Alpinia galanga (L.) Willd. Systematic Reviews in Pharmacy, 11(10), 387–395.

Lawal, O. A., Ogunwande, I. A., & Opoku, A. R. (2014). Constituents of Essential Oils from the Leaf and Flower of Plumeria alba Grown in Nigeria. Natural Product Communication, 9(11), 1613-1614. https://doi.org/10.1177/1934578X1400901121

Mohammed Sur, T., Akbaba, E., Hassan, S. A., & Bagci, E. (2019). Neuropharmacological profile of Hypericum scabrum L. essential oil in rats. Journal of Essential Oil Research, 32(1), 79-87. https://doi.org/10.1080/10412905.2019.1655491

Park, H. J., Lim, E. J., Zhao, R. J., Oh, S. R., Jung, J. W., Ahn, E. M., Lee, E. S., Koo, J. S., Kim, H. Y., Chang, S., Shim, H. S., Kim, K. J., Gwak, Y. S., & Yang, C. H. (2015). Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice. BMC Complementary and Alternative Medicine, 15(1). https://doi.org/10.1186/S12906-015-0571-1

Sohrabi, R., Pazgoohan, N., Seresht, H. R., & Amin, B. (2017). Repeated systemic administration of the cinnamon essential oil possesses anti-anxiety and anti-depressant activities in mice. Iranian Journal of Basic Medical Sciences, 20(6), 708–714. https://doi.org/10.22038/IJBMS.2017.8841

Tuan, N. H., Tung, N. T., & Khanh, P. N. (2019). Research on chemical compositions and anti-microbial activity of the essential oil of the rhizome of Kaempferia daklakensis – A new record from Vietnam flora. Journal of King Saud University - Science, 31(4), 1505–1510. https://doi.org/10.1016/J.JKSUS.2019.07.007

Williams, A. (2015). Spa Bodywork, A Guide for Massage Therapist (A. Williams (ed.); 2nd ed.). Lippincot Williams & Wilkins.

Won, C. L., Jeong, M. S., Chun, I. L., Hyeong, B. P., & Bum, C. L. (2005). Stimulative and sedative effects of essential oils upon inhalation in mice. Archives of Pharmacal Research 2005 28:7, 28(7), 770–774. https://doi.org/10.1007/BF02977341

Wu, Y., Wang, Y., Li, Z. H., Wang, C. F., Wei, J. Y., Li, X. L., Wang, P. J., Zhou, Z. F., Du, S. S., Huang, D. Y., & Deng, Z. W. (2014). Composition of the essential oil from Alpinia galanga rhizomes and its bioactivity on Lasioderma serricorne. Bulletin of Insectology, 67(2), 247–254. h

Zhang, Y., Long, Y., Yu, S., Li, D., Yang, M., Guan, Y., Zhang, D., Wan, J., Liu, S., Shi, A., Li, N., & Peng, W. (2021). Natural volatile oils derived from herbal medicines: A promising therapy way for treating depressive disorder. In Pharmacological Research, 164, 105376. Academic Press. https://doi.org/10.1016/j.phrs.2020.105376

Zhong, Y., Zheng, Q., Hu, P., Huang, X., Yang, M., Ren, G., Du, Q., Luo, J., Zhang, K., Li, J., Wu, H., Guo, Y., & Liu, S. (2019). Sedative and hypnotic effects of compound Anshen essential oil inhalation for insomnia. BMC Complementary and Alternative Medicine, 19(1), 306. https://doi.org/10.1186/s12906-019-2732-0

Downloads

Published

2022-09-23

How to Cite

Nayaka, N. M. D. M. W., Ni Luh Putu Swari, Putu Era Sandhi Kusuma Yuda, & I Gusti Ayu Agung Kusuma Wardani. (2022). Essential Oil of Alpinia galanga: Effect of Aromatherapy Inhalation in Mice and Physicochemical Characterization. Jurnal Ilmiah Medicamento, 8(2), 87–92. https://doi.org/10.36733/medicamento.v8i2.3791

Issue

Section

Original Articles

Most read articles by the same author(s)