The Evolving Trends In Vital Pulp Therapy Through the Application of Various Biomaterials: A Bibliometric Study
DOI:
https://doi.org/10.36733/medicamento.v11i2.11749Keywords:
bibliometric, dentinogenesis, mineral trioxide aggregate, vital pulp therapyAbstract
Vital pulp therapy (VPT) is a crucial dental intervention designed to maintain the vitality of the dental pulp, particularly in carious lesions or trauma. The evolution of biomaterials in VPT has significantly affected dental practices by providing less invasive alternatives that safeguard tooth vitality and functionality. Continued exploration of the properties and effects of these materials is crucial for enhancing treatment strategies and optimizing dental care outcomes. Bibliometric analysis allowed the assessment of trends in the biomaterials used for VPT. Data mining was performed using the Scopus database and Boolean expressions. Data extraction and analysis were conducted using VOSviewer version 1.6.20., VOSviewer thesaurus, and Microsoft Excel. A total of 856 documents were identified, and the United States had the largest number of documents and citations (110 documents, 6,938 citations). The top three sources were the Journal of Endodontics, International Journal of Endodontics, and Dental Materials Journal. Mineral trioxide aggregate (MTA) is still the dominant biomaterial used in VPT to this day. MTA can accelerate dentinogenesis in VPT. The prominence of “MTA” and “VPT” as keywords highlights research on prevalence, causes, prevention, and evaluation, emphasizing the need to investigate biomaterial-driven healing, regeneration, stem cell activity, and gene expression.
References
1. Nie E, Yu J, Jiang R, et al. Effectiveness of direct pulp capping bioactive materials in dentin regeneration: A review. Materials. 2021;14(22). doi:10.3390/ma14226811
2. Hanna SN, Alfayate RP, Prichard J. Vital pulp therapy an insight over the available literature and future expectations. Eur Endod J. 2020;5(3):46-53. doi:10.14744/eej.2019.44154
3. Islam R, Islam MRR, Tanaka T, Alam MK, Ahmed HMA, Sano H. Direct pulp capping procedures – Evidence and practice. Jpn Dent Sci Rev. 2023;59:48-61. doi:10.1016/j.jdsr.2023.02.002
4. Reinnaldi C, Widyastuti W, Ariwibowo T, Laksmiastuti SR. Differences in Niti and Glide Path Rotary System: Preparation of Canal Centering and Transportation in Double-curved Root Canals. Open Dent J. 2025;19(1):1-9. doi:10.2174/0118742106373599250502071822
5. Noor A, Afzal J, Mahmood A, Saad Ullah M, Munawar M, Mutahir Mehdi M. Effectiveness of Calcium Hydroxide (CaOH) as agent for Direct Pulp Capping in the Mandibular Molars. Pakistan Journal of Medical and Health Sciences. 2021;15(10):2524-2526. doi:10.53350/pjmhs2115102524
6. Fibryanto E, Widyastuti W. Effect of brushing the teeth before and after meals on salivary pH: A quasi-experimental study. Journal of International Oral Health. 2022;14(2):163-167. doi:10.4103/jioh.jioh-286-21
7. Al–Saudi KW. A paradigm shift from calcium hydroxide to bioceramics in direct pulp capping: A narrative review. J Conserv Dent Endod. 2024;27(1):2-10. doi:10.4103/jcd.jcd_241_23
8. Varma PVK, Krishna GG, Alla RK, Sowmya S, Swamy KNR, Malkapuram RS. Calcium Hydroxide Pulp Capping Agent: An Overview on Composition, Properties, and Clinical Applications. Uttar Pradesh J Zool. 2023;44(10):63-72. doi:10.56557/upjoz/2023/v44i103507
9. Alhusainy A. Long-Term Outcomes of Vital Pulp Therapy in Deep Carious Lesions Using Bioceramic Materials. J Pharm Bioall Sci. 2024;16(20):S3721-3. doi:10.4103/jpbs.jpbs_1187_24
10. Pushpalatha C, Dhareshwar V, Sowmya S V., et al. Modified Mineral Trioxide Aggregate—A Versatile Dental Material: An Insight on Applications and Newer Advancements. FronBioengBiotechnol. 2022;10:941826. doi:10.3389/fbioe.2022.941826
11. Kadali N, Alla RK, Guduri V, AV R, MC SS, Raju RV. Mineral Trioxide Aggregate: an overview of composition, properties and clinical applications. Int J Dent Mater. 2020;2(1):11-18. doi:10.37983/ijdm.2020.2103
12. AAE Position Statement on Vital Pulp Therapy. J Endod. 2021;47:1340-1344. doi:10.1016/j.joen.2021.07.015
13. Passas I. Bibliometric Analysis: The Main Steps. Encyclopedia. 2024;4(2):1014-1025. doi:10.3390/encyclopedia4020065
14. Hashem E AR, Md Salleh NZ, Abdullah M, Ali A, Faisal F, Nor RM. Research trends, developments, and future perspectives in brand attitude: A bibliometric analysis utilizing the Scopus database (1944–2021). Heliyon. 2022;9(30):12765. doi:10.1016/j.heliyon.2022.e12765
15. Pranckutė R. Web of Science (WoS) and Scopus: the titans of bibliographic information in today’s academic world. Publications.Multidisciplinary Digital Publishing Institute (MDPI). 2021;9(1). doi:10.3390/publications9010012
16. Falagas ME, Pitsouni EI, Malietzis GA, Pappas G. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. FASEB J. 2008;22(2):338-342. doi:10.1096/fj.07-9492lsf
17. Singh VK, Singh P, Karmakar M, Leta J, Mayr P. The journal coverage of Web of Science, Scopus and Dimensions: A comparative analysis. Scientometrics. 2021;126(6):5113-5142. doi:10.1007/s11192-021-03948-5
18. Leong DJX, Yap AU. Vital pulp therapy in carious pulp–exposed permanent teeth: an umbrella review. Clin Oral Investig. 2021;25(12):6743-6756. doi:10.1007/s00784-021-03960-2
19. Duncan HF, Kobayashi Y, Kearney M, Shimizu E. Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials. Bioact Mater. 2023;27:574-593. doi:10.1016/j.bioactmat.2023.04.013
20. Panda P, Govind S, Sahoo SK, et al. Analysis of Pulp Tissue Viability and Cytotoxicity of Pulp Capping Agents. J Clin Med. 2023;12(2):539. doi:10.3390/jcm12020539
21. Podili S, Rizwan R, Kaur A, Lalitha G, Malhotra K. Mineral Trioxide Aggregate (MTA): A Comprehensive Review. J Adv Med Dent Scie Res. 2021;9(7):19-24. doi:10.21276/jamdsr
22. Parirokh M, Torabinejad M. Mineral Trioxide Aggregate: A Comprehensive Literature Review-Part III: Clinical Applications, Drawbacks, and Mechanism of Action. J Endod. 2010;36(3):400-413. doi:10.1016/j.joen.2009.09.009
23. Torabinejad M, Parirokh M. Mineral Trioxide Aggregate: A Comprehensive Literature Review-Part II: Leakage and Biocompatibility Investigations. J Endod. 2010;36(2):190-202. doi:10.1016/j.joen.2009.09.010
24. Kodonas K, Fardi A, Gogos C, Economides N. Scientometric analysis of vital pulp therapy studies. Int Endod J. 2021;54(2):220-230. doi:10.1111/iej.13422
25. Kunert M, Lukomska-Szymanska M. Bio-Inductive Materials in Direct and Indirect Pulp Capping - A Review Article. Materials. 2020;13(5):1204. doi:10.3390/ma13051204

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Copyright (c) 2025 Wiena Widyastuti, Wita Anggraini, Eko Fibryanto, Moehamad Orliando Roeslan, Indrayadi Gunardi, Muhammad Ihsan Rizal, Sobrina Mohamed Khazin, Dewa Made Wedagama

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