The Evolving Trends In Vital Pulp Therapy Through the Application of Various Biomaterials: A Bibliometric Study

Authors

DOI:

https://doi.org/10.36733/medicamento.v11i2.11749

Keywords:

bibliometric, dentinogenesis, mineral trioxide aggregate, vital pulp therapy

Abstract

Vital pulp therapy (VPT) is a crucial dental intervention designed to maintain the vitality of the dental pulp, particularly in carious lesions or trauma. The evolution of biomaterials in VPT has significantly affected dental practices by providing less invasive alternatives that safeguard tooth vitality and functionality. Continued exploration of the properties and effects of these materials is crucial for enhancing treatment strategies and optimizing dental care outcomes. Bibliometric analysis allowed the assessment of trends in the biomaterials used for VPT. Data mining was performed using the Scopus database and Boolean expressions. Data extraction and analysis were conducted using VOSviewer version 1.6.20., VOSviewer thesaurus, and Microsoft Excel. A total of 856 documents were identified, and the United States had the largest number of documents and citations (110 documents, 6,938 citations). The top three sources were the Journal of Endodontics, International Journal of Endodontics, and Dental Materials Journal. Mineral trioxide aggregate (MTA) is still the dominant biomaterial used in VPT to this day. MTA can accelerate dentinogenesis in VPT. The prominence of “MTA” and “VPT” as keywords highlights research on prevalence, causes, prevention, and evaluation, emphasizing the need to investigate biomaterial-driven healing, regeneration, stem cell activity, and gene expression.

Author Biographies

Wiena Widyastuti, Universitas Trisakti

Doctoral Program and Department of Conservative Dentistry, Faculty of Dentistry

Wita Anggraini, Universitas Trisakti

Department of Oral Biology, Faculty of Dentistry

Eko Fibryanto, Universitas Trisakti

Department of Conservative Dentistry, Faculty of Dentistry

Moehamad Orliando Roeslan, Universitas Trisakti

Department of Oral Biology, Faculty of Dentistry

Indrayadi Gunardi, Universitas Trisakti

Department of Oral Medicine, Faculty of Dentistry

Muhammad Ihsan Rizal, Universitas Trisakti

Department of Oral Biology, Faculty of Dentistry

Sobrina Mohamed Khazin, International Islamic University Malaysia

Department of Restorative Dentistry, Kulliyyah of Dentistry

Dewa Made Wedagama, Universitas Mahasaraswati Denpasar

Department of Conservation, Faculty of Dentistry

References

1. Nie E, Yu J, Jiang R, et al. Effectiveness of direct pulp capping bioactive materials in dentin regeneration: A review. Materials. 2021;14(22). doi:10.3390/ma14226811

2. Hanna SN, Alfayate RP, Prichard J. Vital pulp therapy an insight over the available literature and future expectations. Eur Endod J. 2020;5(3):46-53. doi:10.14744/eej.2019.44154

3. Islam R, Islam MRR, Tanaka T, Alam MK, Ahmed HMA, Sano H. Direct pulp capping procedures – Evidence and practice. Jpn Dent Sci Rev. 2023;59:48-61. doi:10.1016/j.jdsr.2023.02.002

4. Reinnaldi C, Widyastuti W, Ariwibowo T, Laksmiastuti SR. Differences in Niti and Glide Path Rotary System: Preparation of Canal Centering and Transportation in Double-curved Root Canals. Open Dent J. 2025;19(1):1-9. doi:10.2174/0118742106373599250502071822

5. Noor A, Afzal J, Mahmood A, Saad Ullah M, Munawar M, Mutahir Mehdi M. Effectiveness of Calcium Hydroxide (CaOH) as agent for Direct Pulp Capping in the Mandibular Molars. Pakistan Journal of Medical and Health Sciences. 2021;15(10):2524-2526. doi:10.53350/pjmhs2115102524

6. Fibryanto E, Widyastuti W. Effect of brushing the teeth before and after meals on salivary pH: A quasi-experimental study. Journal of International Oral Health. 2022;14(2):163-167. doi:10.4103/jioh.jioh-286-21

7. Al–Saudi KW. A paradigm shift from calcium hydroxide to bioceramics in direct pulp capping: A narrative review. J Conserv Dent Endod. 2024;27(1):2-10. doi:10.4103/jcd.jcd_241_23

8. Varma PVK, Krishna GG, Alla RK, Sowmya S, Swamy KNR, Malkapuram RS. Calcium Hydroxide Pulp Capping Agent: An Overview on Composition, Properties, and Clinical Applications. Uttar Pradesh J Zool. 2023;44(10):63-72. doi:10.56557/upjoz/2023/v44i103507

9. Alhusainy A. Long-Term Outcomes of Vital Pulp Therapy in Deep Carious Lesions Using Bioceramic Materials. J Pharm Bioall Sci. 2024;16(20):S3721-3. doi:10.4103/jpbs.jpbs_1187_24

10. Pushpalatha C, Dhareshwar V, Sowmya S V., et al. Modified Mineral Trioxide Aggregate—A Versatile Dental Material: An Insight on Applications and Newer Advancements. FronBioengBiotechnol. 2022;10:941826. doi:10.3389/fbioe.2022.941826

11. Kadali N, Alla RK, Guduri V, AV R, MC SS, Raju RV. Mineral Trioxide Aggregate: an overview of composition, properties and clinical applications. Int J Dent Mater. 2020;2(1):11-18. doi:10.37983/ijdm.2020.2103

12. AAE Position Statement on Vital Pulp Therapy. J Endod. 2021;47:1340-1344. doi:10.1016/j.joen.2021.07.015

13. Passas I. Bibliometric Analysis: The Main Steps. Encyclopedia. 2024;4(2):1014-1025. doi:10.3390/encyclopedia4020065

14. Hashem E AR, Md Salleh NZ, Abdullah M, Ali A, Faisal F, Nor RM. Research trends, developments, and future perspectives in brand attitude: A bibliometric analysis utilizing the Scopus database (1944–2021). Heliyon. 2022;9(30):12765. doi:10.1016/j.heliyon.2022.e12765

15. Pranckutė R. Web of Science (WoS) and Scopus: the titans of bibliographic information in today’s academic world. Publications.Multidisciplinary Digital Publishing Institute (MDPI). 2021;9(1). doi:10.3390/publications9010012

16. Falagas ME, Pitsouni EI, Malietzis GA, Pappas G. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. FASEB J. 2008;22(2):338-342. doi:10.1096/fj.07-9492lsf

17. Singh VK, Singh P, Karmakar M, Leta J, Mayr P. The journal coverage of Web of Science, Scopus and Dimensions: A comparative analysis. Scientometrics. 2021;126(6):5113-5142. doi:10.1007/s11192-021-03948-5

18. Leong DJX, Yap AU. Vital pulp therapy in carious pulp–exposed permanent teeth: an umbrella review. Clin Oral Investig. 2021;25(12):6743-6756. doi:10.1007/s00784-021-03960-2

19. Duncan HF, Kobayashi Y, Kearney M, Shimizu E. Epigenetic therapeutics in dental pulp treatment: Hopes, challenges and concerns for the development of next-generation biomaterials. Bioact Mater. 2023;27:574-593. doi:10.1016/j.bioactmat.2023.04.013

20. Panda P, Govind S, Sahoo SK, et al. Analysis of Pulp Tissue Viability and Cytotoxicity of Pulp Capping Agents. J Clin Med. 2023;12(2):539. doi:10.3390/jcm12020539

21. Podili S, Rizwan R, Kaur A, Lalitha G, Malhotra K. Mineral Trioxide Aggregate (MTA): A Comprehensive Review. J Adv Med Dent Scie Res. 2021;9(7):19-24. doi:10.21276/jamdsr

22. Parirokh M, Torabinejad M. Mineral Trioxide Aggregate: A Comprehensive Literature Review-Part III: Clinical Applications, Drawbacks, and Mechanism of Action. J Endod. 2010;36(3):400-413. doi:10.1016/j.joen.2009.09.009

23. Torabinejad M, Parirokh M. Mineral Trioxide Aggregate: A Comprehensive Literature Review-Part II: Leakage and Biocompatibility Investigations. J Endod. 2010;36(2):190-202. doi:10.1016/j.joen.2009.09.010

24. Kodonas K, Fardi A, Gogos C, Economides N. Scientometric analysis of vital pulp therapy studies. Int Endod J. 2021;54(2):220-230. doi:10.1111/iej.13422

25. Kunert M, Lukomska-Szymanska M. Bio-Inductive Materials in Direct and Indirect Pulp Capping - A Review Article. Materials. 2020;13(5):1204. doi:10.3390/ma13051204

Downloads

Submitted

2025-06-01

Accepted

2025-09-16

Published

2025-09-30

How to Cite

Widyastuti, W., Anggraini, W., Fibryanto, E., Roeslan, M. O., Gunardi, I., Rizal, M. I., … Wedagama, D. M. (2025). The Evolving Trends In Vital Pulp Therapy Through the Application of Various Biomaterials: A Bibliometric Study. Jurnal Ilmiah Medicamento, 11(2), 172–184. https://doi.org/10.36733/medicamento.v11i2.11749

Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.