Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory

Ni Made Dharma Shantini Suena; Ni Luh Wayan Mudia Ariani; Ni Putu Udayana Antari

doi:10.36733/medicamento.v8i1.3425

Authors

Ni Made Dharma Shantini Suena Universitas Mahasaraswati Denpasar
Ni Luh Wayan Mudia Ariani Universitas Mahasaraswati Denpasar
Ni Putu Udayana Antari Universitas Mahasaraswati Denpasar

DOI:

https://doi.org/10.36733/medicamento.v8i1.3425

Keywords:

anti-inflammatory, cream, sandalwood essential oil, Santalum album, sodium lauryl sulfate

Abstract

Inflammation is the body's defense response used to fight agents that cause cell damage in an organism. One source of natural ingredients whose content can be developed as an anti-inflammatory with low side effects is Sandalwood (Santalum album L.). The pharmaceutical preparation chosen for the development of Sandalwood oil as an anti-inflammatory is a cream, because of its several advantages, namely, it is more convenient, practical, easy to use, not sticky, and easy to wash with water so it is easy to clean. The purpose of this study was to determine the physical quality of sandalwood oil cream using two variant concentrations of surfactant sodium lauryl sulfate 1.5% (F1) and 2.5% (F2) as an emulsifying agent, as well as to determine consumer perceptions of sandalwood oil cream. In ensuring pharmaceutical quality, the preparations made must meet several physical parameters including organoleptic tests, homogeneity tests, pH tests, mechanical stability tests, dispersibility tests, and hedonic tests. To find out whether there is a significant difference between F1 and F2, statistical data processing of cream physical quality was performed using SPSS 20 with an unpaired T-test if the data were normally distributed, and if the data were not normally distributed, the Mann-Whitney test was performed. The results of the research that has been carried out show that overall the two cream formulas have good physical quality and are quite liked by the panelists. From the results of the organoleptic test, homogeneity test, and pH test, it is known that F1 and F2 have no difference, and the results of the dispersion test and hedonic test show that there is no significant difference between F1 and F2.

Author Biographies

Ni Made Dharma Shantini Suena, Universitas Mahasaraswati Denpasar

Department of Pharmaceutics, Pharmacy Bachelor Program, Faculty of Pharmacy

Ni Luh Wayan Mudia Ariani, Universitas Mahasaraswati Denpasar

Fakultas Farmasi

Ni Putu Udayana Antari, Universitas Mahasaraswati Denpasar

Departemen Farmasi Sosial, Program Studi Sarjana Farmasi, Fakultas Farmasi

References

Ambari, Y. and Suena, N. M. D. S. (2019) ‘UJI STABILITAS FISIK FORMULASI LOTION ANTI NYAMUK MINYAK SEREH’, Jurnal Ilmiah Medicamento, 5(2), pp. 111–115. doi: 10.36733/medicamento.v5i2.844.

Arisanty, A. and Anita, A. (2018) ‘UJI MUTU FISIK SEDIAAN KRIM EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.) DENGAN VARIASI KONSENTRASI NA. LAURIL SULFAT’, Media Farmasi, 14(1), p. 22. doi: 10.32382/mf.v14i1.80.

Ariyanti, M. and Asbur, Y. (2018) ‘Cendana (Santalum album L.) sebagai tanaman penghasil minyak atsiri’, Kultivasi, 17(1), pp. 558–567. doi: 10.24198/kultivasi.v17i1.15804.

Baylac, S. (2003) ‘Inhibition of 5-lipoxygenase by essential oils and other natural fragrant extracts’, International Journal of Aromatherapy, 13(2–3), pp. 138–142. doi: 10.1016/S0962-4562(03)00083-3.

Cendana, Y., Adrianta, K.A. and Suena, N.M.D.S., 2021. Formulasi Spray Gel Minyak Atsiri Kayu Cendana (Santalum album L.). Jurnal Ilmiah Medicamento, 7(2), pp.84-89. https://doi.org/10.36733/medicamento.v7i2.2272

Djiobie Tchienou, G. E. et al. (2018) ‘Multi-Response Optimization in the Formulation of a Topical Cream from Natural Ingredients’, Cosmetics, 5(1), pp. 1–14. doi: 10.3390/cosmetics5010007.

Harlim, A. (2018) BUKU AJAR ILMU KESEHATAN KULIT DAN KELAMIN IMUNOLOGI INFLAMAS. 1st edn. Jakarta: Fakultas Kedokteran Universitas Kristen Indonesi.

Iskandar, B. et al. (2021) ‘FORMULASI, KARAKTERISASI DAN UJI STABILITAS MIKROEMULSI MINYAK NILAM (Pogostemon cablin Benth.)’, Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan, 6(2), pp. 282–291. doi: 10.36387/jiis.v6i2.724.

Jain, R. and Nair, S. (2019) ‘Sandalwood Oil for the Chemoprevention of Skin Cancer: Mechanistic Insights, Anti-inflammatory, and In Vivo Anticancer Potential’, Current Pharmacology Reports, 5(5), pp. 345–358. doi: 10.1007/s40495-019-00195-4.

Li, G. et al. (2013) ‘Comparative Effects of Sandalwood Seed Oil on Fatty Acid Profiles and Inflammatory Factors in Rats’, Lipids, 48(2), pp. 105–113. doi: 10.1007/s11745-012-3752-4.

Lumentut, N., Edi, H. J. and Rumondor, E. M. (2020) ‘Formulasi dan Uji Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Buah Pisang Goroho (Musa acuminafe L.) Konsentrasi 12.5% Sebagai Tabir Surya’, Jurnal MIPA, 9(2), p. 42. doi: 10.35799/jmuo.9.2.2020.28248.

Mulyani, E. (2019) ‘Studi In Vitro: Efek Anti Kolesterol Ekstrak Daun Rambusa (Passiflora foetida L)’, Jurnal Surya Medika, 4(2), pp. 60–65. doi: 10.33084/jsm.v4i2.606.

Naibaho, O. H., Yamlean, P. V. Y. and Wiyono, W. (2013) ‘Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocimum sanctum L.) Pada Kulit Punggung Kelinci yang Dibuat Infeksi Staphylococcus aureus’, Jurnal Ilmiah Farmasi-UNSRAT, 2(02), pp. 27–34.

Nurhayati, O. F. (2019) ‘EFEK SEDUHAN BIJI KOPI ROBUSTA (Coffea canephora) TERHADAP JUMLAH SEL LIMFOSIT PADA TIKUS WISTAR JANTAN YANG DIINDUKSI Staphylococcus aureus’, Skripsi.

Prasetyaningtyas, Cantiknianti ; Iksanudin, A. (2011) Pengaruh Penambahan Konsentrasi Na Lauril Sulfat Sebagai Emulgator Dalam Basis Cold Cream Repelan Minyak Atsiri Daun Sere (Cymbopogon citratus (DC)Stapf) Terhadap Nyamuk Aedes Aegypti Betina Serta Uji Sifat Fisiknya. Yogyakarta.

Pratasik, M. C. M., Yamlean, P. V. Y. and Wiyono, W. I. (2019) ‘FORMULASI DAN UJI STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SESEWANUA (Clerodendron squamatum Vahl.)’, Pharmacon, 8(2), p. 261. doi: 10.35799/pha.8.2019.29289.

Puspawati, N. M. et al. (2017) ‘UJI AKTIVITAS ANTIINFLAMASI FRAKSI N-HEKSAN DAUN CENDANA (Santalum album Linn.) TERHADAP OEDEM TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI KARAGENAN’, Cakra Kimia (Indonesian E-Journal of Applied Chemistry), 5, pp. 102–108.

Rowe, R. C., Sheskey, P. J., & Quinn, M. E. (2009) Handbook of Pharmaceutical Excipients. Sixth Edit. London.

Rudiyat, A., Yulianti, R. and Indra, I. (2020) ‘Formulasi Krim Anti Jerawat Kestrak Etanol Kulit Pisang Kepok (Musa Balbisiana colla)’, Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi, 20(2), pp. 170–180.

Sardiana, I. K. and Dinata, K. K. (2010) ‘Studi Pemanfaatan Tanaman Pada Kegiatan Ritual ( Upakara ) Oleh Umat Hindu Di Bali’, Jurnal Bumi Lestari, 10(1), pp. 123–127.

Shankar, R. et al. (2016) ‘Formulation and characterization of polyherbal cream for skin manifestations’, Journal of Asian Association of Schools of Pharmacy, 1(January), pp. 360–366.

Sharma, M. et al. (2014) ‘Suppression of Lipopolysaccharide-stimulated Cytokine/Chemokine Production in Skin Cells by Sandalwood Oils and Purified α-santalol and β-santalol’, Phytotherapy Research, 28(6), pp. 925–932. doi: 10.1002/ptr.5080.

Sharma, M. et al. (2017) ‘East Indian Sandalwood Oil (EISO) Alleviates Inflammatory and Proliferative Pathologies of Psoriasis’, Frontiers in Pharmacology, 8(MAR), pp. 1–13. doi: 10.3389/fphar.2017.00125.

Sharma, M. et al. (2018) ‘East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease’, Frontiers in Pharmacology, 9(MAR), pp. 1–12. doi: 10.3389/fphar.2018.00200.

Sriwati, E., Waris, W. and Anitasari, S. D. (2019) ‘Potensi Daun Tembelekan (Lantana camara L.) untuk Sediaan Krim Wajah Alami’, BIO-CONS, Jurnal Biologi & Konservasi, 1(2), pp. 38–45. Available at: https://jurnal.ikipjember.ac.id/index.php/biocons/article/view/257.

Suena, N. M. D. S., Antari, N. P. U. and Cahyaningsih, E. (2017) ‘Evaluasi Mutu Fisik Formula Body Butter Ekstrak Etanol Kulit Buah Manggis ( Garcinia mangostana L .) ( Physical Quality Evaluation Of Body Butter Formulation From Etanol Extract Of Mangosteen ( Garcinia Mangostana L .) Rind )’, Jurnal Ilmu Kefarmasian Indonesia, 15(1), pp. 63–69.

Suena, N. M. D. S., Meriyani, H. and Antari, N. P. U. (2020) ‘UJI MUTU FISIK DAN UJI HEDONIK BODY BUTTER MASERAT BERAS MERAH JATILUWIH’, Jurnal Ilmiah Medicamento, 6(1), pp. 59–65. doi: 10.36733/medicamento.v6i1.843.

Yuliarto, F. T., Khasanah, L. U. and Anandito, R. B. K. (2012) ‘PENGARUH UKURAN BAHAN DAN METODE DESTILASI (DESTILASI AIR DAN DESTILASI UAP-AIR) TERHADAP KUALITAS MINYAK ATSIRI KULIT KAYU MANIS (Cinnamomum burmannii)’, 1(1).