Acne Skincare: Formulation of Peel-Off Gel Mask with Ethyl p-Methoxycinnamate from Kaempferia galanga L. using Polyvinyl Alcohol as a Gelling Agent
DOI:
https://doi.org/10.36733/medicamento.v11i2.11465Keywords:
anti-acne peel-off gel mask, ethyl P-Methoxycinnamate, formulation, Kaempferia galanga L.Abstract
Herbal medicines are increasingly used as antibacterial therapy due to their accessibility and affordability. Kaempferia galanga L. (kencur) rhizome contains ethyl p-methoxycinnamate (EPMS), an active compound with anti-acne properties. EPMS at 1.2% in cream formulations has shown antibacterial activity against Propionibacterium acnes, Staphylococcus epidermidis, and Staphylococcus aureus. However, creams are unsuitable for oily skin as they may worsen acne. Peel-off gels offer a better alternative because it is non-greasy, supports exfoliation, stimulates cell regeneration, minimizes pores, and helps cleanse and moisturize the skin. This study aimed to formulate a physically stable anti-acne peel-off gel containing EPMS using polyvinyl alcohol (PVA) at 10% and 12%. EPMS was isolated from kencur rhizome and incorporated into gel bases. Evaluations included organoleptic properties, viscosity, homogeneity, pH, drying time, spreadability, and accelerated stability at 27 ± 2 °C and 40 ± 2 °C for 21 days. Results showed that EPMS can be successfully formulated into peel-off gels with PVA 10% and 12%. The gels exhibited yellowish-white color, honey-like odor, homogeneity, pH 5.21–5.35, drying time 17–30 minutes, spreadability 55–68 mm, and viscosity 4,900–16,000 cPs. All formulations maintained physical stability under test conditions. This study provides a scientific basis for the development of natural-based cosmetic products that are safe, particularly for oily skin, and do not worsen acne conditions.
References
1. Chali BU, Hasho A, Koricha NB. Preference and Practice of Traditional Medicine and Associated Factors in Jimma Town, Southwest Ethiopia. Evidence-based Complement Altern Med. 2021;2021. doi:10.1155/2021/9962892
2. Khairullah AR, Solikhah TI, Ansori ANM, et al. Medicinal importance of kaempferia galanga l. (zingiberaceae): A comprehensive review. J HerbMed Pharmacol. 2021;10(3):281-288. doi:10.34172/jhp.2021.32
3. Elya B, Kusuma IM, Jufri M, Handayani R. Antibacterial tests against acne in vitro, the physical stability and patch test using cream containing ethyl p-methoxycinnamate extracted from Kaempferia galanga L., Rhizoma. Res J Med Plant. 2016;10(8). doi:10.3923/rjmp.2016.426.434
4. Sriarumtias FF, Mahendra Rizkio Syamsudin RA, Ummah L, Abdillah FF. Formulasi dan Karakterisasi Mikroemulgel Etil P-Metoksisinamat (EPMS) dari Rimpang Kencur (Kaempferia galanga Linn). J Kefarmasian Akfarindo. 2022;7(1):8-14. doi:10.37089/jofar.vi0.106
5. Agustina A, Munawarah M, Lumi SA, Nur S. Green Synthesis Nanopartikel Perak (Agnps) Terkonjugasi Etil Parametoksi Sinamat (EPMS) sebagai Bahan Tabir Surya. J Farm Galen (Galenika J Pharmacy). 2018;4(2):98-105. doi:10.22487/j24428744.2018.v4.i2.10440
6. Devin Suwandi M, Monica E, Rollando R. Formulasi Dan Uji Mutu Fisik Krim Anti Jerawat Ekstrak Bunga Lawang Illicium Verum. Sainsbertek J Ilm Sains Teknol. 2023;3(2):42-51. doi:10.33479/sb.v3i2.224
7. Hanum Ismanelly T, Laila L. Evaluation of anti-aging and anti-acne effect of andaliman (Zanthoxylum Acanthopodium DC.) ethanolic extract peel off gel mask. Asian J Pharm Clin Res. 2018;11(Special Issue 1):90-93. doi:10.22159/ajpcr.2018.v11s1.26576
8. Winingrum LA, Zai K. Optimization of peel-off gel mask formula containing Binahong (Anredera cordifolia) leaf extract based PVACMC-alginate combination. J Res Pharm. 2024;28(6):1953-1962. doi:10.29228/jrp.868
9. Hawaisa S, Rosita N, Soeratri W. Effects of Polyvinyl Alcohol and Hydroxypropyl Methylcellulose Combination on Physical Stability and Irritability of Gluthathione Peel-Off Masks. Trop J Nat Prod Res. 2023;7(11):5081-5086. doi:10.26538/tjnpr/v7i11.10
10. Nemati MM, Abedi M, Ghasemi Y, Ashrafi H, Haghdel M. Formulation and evaluation of antioxidant and antibacterial activity of a peel-off facial masks moisturizer containing curcumin and Rosa Damascena extract. J Cosmet Dermatol. 2024;23(6):2156-2169. doi:10.1111/jocd.16255
11. Ririn R, Purnamasari M V, Ulfah N. Formulasi Sediaan Masker Peel Off dari Ekstrak Buah Alpukat (Persea Americana Mill.) dengan Variasi Konsentrasi Polivinil Alkohol (PVA). J Pharm Heal Res. 2023;4(2):303-311. doi:10.47065/jharma.v4i2.3605
12. Yener G, Incegül T, Yener N. Importance of using solid lipid microspheres as carriers for UV filters on the example octyl methoxy cinnamate. Int J Pharm. 2003;258(1-2):203-207. doi:10.1016/S0378-5173(03)00203-5
13. Ingeswari AV, Khozin MN, Fadlan A, Santoso M, Nugraheni ZV, Sarmoko. Isolation of Ethyl Trans-P-Methoxycinnamate from Kaempferia galanga L. Rhizomes by using n-Hexane. J Kim Ris. 2024;9(1):69-77. doi:10.20473/jkr.v9i1.58165
14. Wulansari E, Siswanto A. Article history: Combination of HPMC and PVA using Factorial Design Method. J Kefarmasian Indones. 2025;15(1):34-45. https://doi.org/10.22435/jki.v15i1.6700
15. Ahirwal U, Namdev N, Kansare A. Formulation and Evaluation of Coffee and Turmeric Peel-Off Face Gel Mask. World J Pharm Sci Res. 2024;3(1):70. www.wjpsronline.com
16. Febriani A, Maruya I, Sulistyaningsih F. Formulasi dan Uji Iritasi Sediaan Gel Kombinasi Ekstrak Etanol Rimpang Kencur (Kaempferia galanga L.) dan Ekstrak Etanol Herba Pegagan (Centella asiatica (L.) Urban). J Ilmu Kefarmasian. 2020;13(1):45-54.
17. Yang L, Wen KS, Ruan X, Zhao YX, Wei F, Wang Q. Response of plant secondary metabolites to environmental factors. Molecules. 2018;23(4):1-26. doi:10.3390/molecules23040762
18. Rahmasari D, Ermawati D, Nugraheni RW, Putri DR, Pratiwi IN. Design and Development of Peel-off Mask Gel Formulation of Citronella Oil for Acne Vulgaris. 2020;(Hsic 2019):157-163. doi:10.5220/0009126101570163
19. Lukić M, Pantelić I, Savić SD. Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products. Cosmetics. 2021;8(3). doi:10.3390/cosmetics8030069
20. Tanjung YP, Julianti AI, Isnayanti I, Agustin R. Formulation and Evaluation of Peel Off Gel Facial Mask From Arabica Coffee Fruit Peel Extract (Coffea Arabica L.). Int J Appl Pharm. 2021;13(special issue 4):148-151. doi:10.22159/IJAP.2021.V13S4.43845
21. Prasetyo BE, Rafika D, Laila L, Aminah F. Physical evaluation and anti-aging effect of red bean ethanolic extract (Vigna angularis (wild.) ohwi & ohashi) peel-off gel mask. Open Access Maced J Med Sci. 2019;7(22):3907-3910. doi:10.3889/oamjms.2019.531
22. Kryscio DR, Sathe PM, Lionberger R, et al. Spreadability measurements to assess structural equivalence (Q3) of topical formulations - A technical note. AAPS PharmSciTech. 2008;9(1):84-86. doi:10.1208/s12249-007-9009-5
23. Raju SP, Sachdev M, Khunger N, ... Mask acne in skin of color: a significant dermatological condition amidst the COVID-19 pandemic. J Clin …. Published online 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC9017666/
24. Yudistin Ramba W, Sahumena MH, Nasir NH. Formulasi Sediaan Masker Gel Peel-Off Ekstrak Etanol Kulit Buah Pisang Kepok (Musa paradisiaca L.) Sebagai Antioksidan. J Pharm Mandala Waluya. 2023;2(1):43-55. doi:10.54883/jpmw.v2i1.61
25. Mortezapour S, Eslami H, Nedaaee Oskoee E. Rheology and morphology of no-slip sheared polymer nanocomposite under creep condition. J Chem Phys. 2015;143(3). doi:10.1063/1.4926618
26. Septiani HN, - L. Pengaruh Konsentrasi Ekstrak (Pandanus amaryllifolius Roxb.) dalam Sediaan Gel terhadap Karakteristik Fisik, Stabilitas Fisik, Aktivitas Antioksidan dan Hedonik. Parapemikir J Ilm Farm. 2022;11(2):131. doi:10.30591/pjif.v11i2.3006
27. Hwang JH, Lee S, Lee HG, Choi D, Lim KM. Evaluation of Skin Irritation of Acids Commonly Used in Cleaners in 3D-Reconstructed Human Epidermis Model, KeraSkinTM. Toxics. 2022;10(10). doi:10.3390/toxics10100558
28. Hanum TI, Marianne M, Sumaiyah S, Hasibuan PAZ, Hasibuan WF, Bestari KC. Formulasi Sediaan Masker Gel Peel-Off Kopi Robusta (Coffea canephora) dan Efektivitasnya sebagai Anti Penuaan Dini. Indones J Pharm Clin Res. 2025;8(01):7-14. doi:10.32734/idjpcr.v8i01.19940
29. Raju T. Design, Formulation and Optimization of Peel-Off Face Mask Gel for the Symptomatic Treatment of Rosacea. J Pharm Res Sci Technol. 2022;6(2):96-104. doi:10.31531/jprst.1000164
30. Thewanjutiwong S, Phokasem P, Disayathanoowat T, Juntrapirom S, Kanjanakawinkul W, Chaiyana W. Development of Film-Forming Gel Formulations Containing Royal Jelly and Honey Aromatic Water for Cosmetic Applications. Gels. 2023;9(10). doi:10.3390/gels9100816
31. Slamet S, Anggun BD, Pambudi DB. Uji Stabilitas Fisik Formula Sediaan Gel Ekstrak Daun Kelor (Moringa Oleifera Lamk.). J Ilm Kesehat. 2020;13(2):115-122. doi:10.48144/jiks.v13i2.260
32. Muaadh A. MA, Basheer M. K. Development And Characterization Of Peel-Off Gel Masks Incorporating Activated Charcoal And Salicylic Acid For Enhanced Skin Radiance And Rejuvenation. Int J Pharm Sci. 2024;02(08):3024-3035. doi:10.5281/zenodo.13294605

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