Bibliometric Analysis of Polyherbal Formulations as Aphrodisiacs: A Review of Current Research Trends

Authors

  • I Gusti Agung Ayu Kartika Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar https://orcid.org/0000-0002-7170-2494
  • Iwan Saka Nugraha Institut Teknologi dan Kesehatan Bintang Persada
  • Ida Bagus Putra Mahardika Institut Teknologi dan Kesehatan Bintang Persada
  • Suryani Universitas Jenderal Achmad Yani

DOI:

https://doi.org/10.36733/medicamento.v11i2.11418

Keywords:

aphrodisiac, herbal combination, polyherbal formulation, sexual health, therapeutic potential

Abstract

In recent years, the therapeutic potential of polyherbal formulations as aphrodisiacs, particularly as natural alternatives to synthetic treatments for sexual health disorders, has garnered significant attention. Polyherbal formulations are believed to enhance efficacy through synergistic effects, making them a preferred option in both traditional and modern therapeutic practices. This review aims to provide a comprehensive analysis of research trends relating to the use of polyherbal formulations for aphrodisiac purposes. A bibliometric analysis was conducted using the Scopus database, extracting relevant articles with the keywords 'Aphrodisiac AND Polyherbal OR Combination.' From an initial pool of 88 articles, 16 were selected for in-depth analysis. VOSviewer software was used to visualize collaboration networks, co-authorship patterns, and keyword trends, highlighting the increasing research interest in polyherbal formulations for sexual health enhancement. The narrative review supplements these findings by exploring study methodologies, sources of herbal ingredients, formulation compositions, and commonly used herbs. Results indicate that while polyherbal aphrodisiac formulations show promising therapeutic potential, research in this field remains fragmented, with limited clinical trials evaluating safety and efficacy. The most frequently studied herbs include Tribulus terrestris, Mucuna pruriens, and Withania somnifera, known for their effects on testosterone levels, vascular function, and libido enhancement. Future studies should focus on clinical validation, standardization, and pharmacokinetic assessments to facilitate their integration into modern medical practice. These findings provide valuable insights for researchers and industries developing polyherbal-based nutraceutical and pharmaceutical products.

Author Biographies

I Gusti Agung Ayu Kartika, Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar

Yoga and Health Study Program, Faculty of Brahma Widya

Iwan Saka Nugraha, Institut Teknologi dan Kesehatan Bintang Persada

Community Clinical Pharmacy Undergraduate Study Program, Faculty of Health

Ida Bagus Putra Mahardika, Institut Teknologi dan Kesehatan Bintang Persada

Community Clinical Pharmacy Undergraduate Study Program, Faculty of Health

Suryani, Universitas Jenderal Achmad Yani

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy

References

1. Leisegang K, Finelli R. Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review. Arab J Urol. 2021;19(3):323-339. doi:10.1080/2090598X.2021.1926753

2. Ara I, Maqbool M, Bukhari B, Ara N, Hajam TA. Present Status, Standardization and Safety Issues with Herbal Drugs. Int J Res Pharm Sci Technol. 2020;1(3):95-101. doi:10.33974/ijrpst.v1i3.169

3. Karole S, Shrivastava S, Thomas S, et al. Polyherbal Formulation Concept for Synergic Action: A Review. J Drug Deliv Ther. 2019;9(1-s):453-466. doi:10.22270/jddt.v9i1-s.2339

4. Jeong JY, Jung IG, Yum SH, Hwang YJ. In Vitro Synergistic Inhibitory Effects of Plant Extract Combinations on Bacterial Growth of Methicillin-Resistant Staphylococcus aureus. Pharmaceuticals. 2023;16(10):1491. doi:10.3390/ph16101491

5. Parveen A, Zahiruddin S, Agarwal N, Siddiqui MA, Ansari SH, Ahmad S. Modulating effects of the synergistic combination of extracts of herbal drugs on cyclophosphamide-induced immunosuppressed mice. Saudi J Biol Sci. 2021;28(11):6178. doi:10.1016/j.sjbs.2021.06.076

6. Ainurofiq A, Wiyono N, Warni R, Choiri S. Assessment of the synergistic effect of a poly-herbals combination on the antioxidant activity through a statistical approach. F1000Research. 2023;11:1327. doi:10.12688/f1000research.126579.2

7. Partan RU, Hidayat R, Saleh MI. Potential efficacy of extracts of Pimpinela alpina, Tribulus terestris and Eurycoma longifolia in increasing sexual activity in male wistar rats. Med Plants. 2018;10(1):52-57. doi:10.5958/0975-6892.2018.00008.4

8. Sahoo HB, Nandy S, Senapati AK, Sarangi SP, Sahoo SK. Aphrodisiac activity of polyherbal formulation in experimental models on male rats. Pharmacogn Res. 2014;6(2):120-126. doi:10.4103/0974-8490.129029

9. Ara A, Vishvkarma R, Mehta P, Rajender S. The Profertility and Aphrodisiac Activities of Tribulus terrestris L.: Evidence from Meta-Analyses. Andrologia. 2023;2023(1):7118431. doi:10.1155/2023/7118431

10. Falagas ME, Pitsouni EI, Malietzis GA, Pappas G. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. FASEB J. 2008;22(2):338-342. doi:10.1096/fj.07-9492LSF

11. Rodríguez-Redondo Y, Denche-Zamorano A, Muñoz-Bermejo L, et al. Bibliometric Analysis of Nature-Based Therapy Research. Healthcare. 2023;11(9):1249. doi:10.3390/healthcare11091249

12. Musa TH, Musa IH, Osman W, Campbell MC, Musa HH. A bibliometric analysis of global scientific research output on Gum Arabic. Bioact Carbohydr Diet Fibre. 2021;25:100254. doi:10.1016/j.bcdf.2020.100254

13. Kang DY, Kim H, Kim KW, Chung WS. Bibliometric analysis of research relating to the use of herbal medicine for rheumatoid arthritis between 1991 to 2021. Medicine (Baltimore). 2022;101(37):e30413. doi:10.1097/MD.0000000000030413

14. Hou A, Yang L, Lü J, Yang L, Kuang H, Jiang H. A bibliometrics visualization analysis and hotspots prediction for natural product on osteoporosis research from 2000 to 2021. J Future Foods. 2022;2(4):326-337. doi:10.1016/j.jfutfo.2022.08.004

15. Kanase VG, Kini R, Maniyar D, Shettigar S. Effect of Advertised Polyherbal (Ayurvedic) Aphrodisiac Formulations on Potent Male Albino Rats. Asian J Pharm Clin Res. Published online May 7, 2020:51-53. doi:10.22159/ajpcr.2020.v13i5.36022

16. Sahin K, Tuzcu M, Orhan C, et al. MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO-1 Pathway While Reducing Oxidative Damage in Male Rats. Evid-Based Complement Altern Med ECAM. 2018;2018:8521782. doi:10.1155/2018/8521782

17. Khan MB, Rathi BJ, Rajput D, Wanjari A. A review on classical Vajikarana formulations of Shweta Musali. J Indian Syst Med. 2019;7(4):205. doi:10.4103/JISM.JISM_67_19

18. Arletti R, Benelli A, Cavazzuti E, Scarpetta G, Bertolini A. Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats. Psychopharmacology (Berl). 1999;143(1):15-19. doi:10.1007/s002130050913

19. Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014(1):179529. doi:10.1155/2014/179529

20. Mahajan GK, Mahajan AY, Mahajan RT. Efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males. J Complement Integr Med. 2012;9:Article 6. doi:10.1515/1553-3840.1520

21. Hsieh CH, Tsai HC, Hsu GL, Chen CC, Hsu CY. Herb formula enhances treatment of impotent patients after penile venous stripping: a randomised clinical trials. Andrologia. 2016;48(7):754-760. doi:10.1111/and.12508

22. Worp HB van der, Howells DW, Sena ES, et al. Can Animal Models of Disease Reliably Inform Human Studies? PLOS Med. 2010;7(3):e1000245. doi:10.1371/journal.pmed.1000245

23. Singh R, Ali A, Jeyabalan G, Semwal A, Jaikishan. An overview of the current methodologies used for evaluation of aphrodisiac agents. J Acute Dis. 2013;2(2):85-91. doi:10.1016/S2221-6189(13)60105-5

24. Tajudin T, Indratmoko S, Prawatya AN. Optimasi Formula Nanohydrogel Icariin Sebagai Afrodisiak.: Optimization of Icariin Nanohydrogel Formula as an Aphrodisiac. J Tumbuh Obat Indones. 2023;16(2):137-155. doi:10.31002/jtoi.v16i2.998

25. Kaspate D, Ziyaurrahman AR, Saldanha T, Kale P. Preclinical evaluation of Polyherbal Formulation for female sexual dysfunction. Int J Pharma Bio Sci. 2015;6(1):P639-P671.

26. Nouioura G, Lyoussi B, Derwich E. Rekindling desire: Unveiling the Aphrodisiac potential of Apiaceae Elixirs. Phytomedicine Plus. 2024;4(2):100530. doi:10.1016/j.phyplu.2024.100530

27. Vijayanarayana K, Rao PGM, Chacko N, Kishore GS, Udupa N. Aphrodisiac activity of geyenaphro: A poly herbal formulation in rats. Pharmacologyonline. 2010;1:607-613.

28. Nagaphani K, Khalid MdS, Gouda TS, et al. Effect of polyherbal formulation androcare, for its aphrodisiac activity. Pharmacologyonline. 2009;2:354-364.

29. Khan MB, Rathi BJ, Thakur SK. Evaluation of Spermatogenic Activity of Polyherbal Compound Musalyadi Churna and its Protective Effect Against Nicotine‑Induced Testicular Degeneration in Sprague–Dawley Rats. J Pharm Bioallied Sci. 2024;16(1):8-15. doi:10.4103/jpbs.jpbs_825_23

30. Gurav N, Gurav S, Wanjari M, Prasad S, Wayal S, Rarokar N. Development and evaluation of aphrodisiac potential of a classical ayurvedic formulation, ‘Kaamdev ghrita’ in rat model. J Ayurveda Integr Med. 2021;12(2):294-301. doi:10.1016/j.jaim.2020.09.007

31. Johri PK, Tripathi R, Johri R. Testicular protein profile(SDS-PAGE) study of tested reversibile male antifertility and aphrodisiac polyherbal preparation fed albino rats with special reference to zinc deficiency. Biochem Cell Arch. 2013;13(2):277-279.

32. Bojja SL, Kolathur KK, Chaudhari BB, et al. Poweromin X Ten, a polyherbal formulation improves male sexual function: In vivo and network pharmacology study. F1000Research. 2024;13:260. doi:10.12688/f1000research.145889.2

33. Ara A, Vishvkarma R, Mehta P, Rajender S. The Profertility and Aphrodisiac Activities of Tribulus terrestris L.: Evidence from Meta-Analyses. Andrologia. 2023;2023(1):7118431. doi:10.1155/2023/7118431

34. Nipanikar S, Nagore D, Chitlange S. Evaluation of aphrodisiac activity of AHPL/AYCAP/0114 capsule in sexually sluggish male rats. Pharmacogn Mag. 2018;14(55):S264-S267. doi:10.4103/pm.pm_363_17

35. Suresh S, Prakash S. Effect of Mucuna pruriens (Linn.) on sexual behavior and sperm parameters in streptozotocin-induced diabetic male rat. J Sex Med. 2012;9(12):3066-3078. doi:10.1111/j.1743-6109.2010.01831.x

36. Sahin K, Orhan C, Akdemir F, et al. Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats. BMC Complement Altern Med. 2016;16(1):318. doi:10.1186/s12906-016-1303-x

37. Chauhan S, Srivastava MK, Pathak AK. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial. Health Sci Rep. 2022;5(4):e741. doi:10.1002/hsr2.741

38. Nasimi Doost Azgomi R, Zomorrodi A, Nazemyieh H, et al. Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence. BioMed Res Int. 2018;2018:4076430. doi:10.1155/2018/4076430

39. Tajuddin null, Ahmad S, Latif A, Qasmi IA. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study. BMC Complement Altern Med. 2003;3:6. doi:10.1186/1472-6882-3-6

40. Tajuddin null, Ahmad S, Latif A, Qasmi IA, Amin KMY. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med. 2005;5:16. doi:10.1186/1472-6882-5-16

41. Bansode FW, Arya KR, Singh RK, Narender T. Dose-dependent effects of Asparagus adscendens root (AARR) extract on the anabolic, reproductive, and sexual behavioral activity in rats. Pharm Biol. 2015;53(2):192-200. doi:10.3109/13880209.2014.913295

42. Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine Int J Phytother Phytopharm. 2001;8(5):401-409. doi:10.1078/0944-7113-00060

43. Abushammala IM. INTERACTION OF SILDENAFIL WITH HERBAL SUPPLEMENTS: A REVIEW. Bull Pharm Sci Assiut Univ. 2021;44(2):291-300. doi:10.21608/bfsa.2021.207145

44. Senthilkumaran S, Balamurugan N, Suresh P, Thirumalaikolundusubramanian P. Priapism, pomegranate juice, and sildenafil: Is there a connection? Urol Ann. 2012;4(2):108-110. doi:10.4103/0974-7796.95560

45. Kunle, Folashade O, Egharevba, Omoregie H, Ahmadu, Ochogu P. Standardization of herbal medicines - A review. Int J Biodivers Conserv. 2012;4(3):101-112. doi:10.5897/IJBC11.163

46. Bhairam M, Roy A, Bahadur S, Banafar A, Turkane D. Standardization of Herbal Medicines – an Overview. J Appl Pharm Res. 2013;1(1):14-21.

47. Rani S, Manju SL. Formulation and Standardization of Polyherbal Antihyperlipidemic Formulation. J Nat Remedies. 2021;20(4):228. doi:10.18311/jnr/2020/24795

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Submitted

2025-03-26

Accepted

2025-07-03

Published

2025-09-27

How to Cite

Kartika, I. G. A. A., Nugraha, I. S., Mahardika, I. B. P., & Suryani, S. (2025). Bibliometric Analysis of Polyherbal Formulations as Aphrodisiacs: A Review of Current Research Trends. Jurnal Ilmiah Medicamento, 11(2), 139–151. https://doi.org/10.36733/medicamento.v11i2.11418

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