TEKNIK BONE TISSUE ENGINEERING (BTE) UNTUK REGENERASI JARINGAN PERIODONTAL DAN ESTETIK PADA EDENTULOUS RIDGE
The resorption of alveolar bone in the edentulous area can lead to reduced prosthetic support and loss of periodontal tissue attachment, and reduce aesthetics. Dental implants are an alternative treatment option for patients with partial or complete loss of teeth. Not all dental implants provide good results, especially in relation to bone contact with implants. One way to overcome alveolar bone deficiency is implant placement with bone grafting procedures. Bone Tissue Engineering (BTE) can be performed in the edentulous area that experiences alveolar bone resorption, to replace lost bone (osteoconduction) and stimulate new bone formation (osteoinduction), so that the denture in the edentulous area is better with adequate support, and more aesthetics. Osteon (Biphasic Calcium Phosphate) is one of the unique products made from marine coral, which contains Calcium Carbonate in the structure of Calcium Hydroxyapatite. The advantage of this material is that the structure of the sea coral is similar to trabecular bone. Biphasic Calcium Phosphate has several disadvantages, namely slow degradation rates, weak resistance to fractures, high crystallinity, and has limitations in stimulating the regeneration of bone cells; and coated with collagen, so that it can enable immunological / allergic reactions in patients who have hypersensitivity.
Peng L, Jia Z, Yin X, Zhang X, Liu Y, Chen P, Ma K, Zhou C. Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue. Stem Cells Dev, 2008,Vol.4:p.761-73.
Winoto, A. Comparative analysis of mesenchymal stem cell from bone marrow and adipose tissue for osteogenic differentiation, 2010, p.38.
Zhang, N., wu, Y. P., Qian, S. J., Teng, C., Chen, S., & Li, H. Review article: Research progresss in the mechanism of effect of PRP in bone deficiency healing, 2013.
Sachlos E, Czernuszka JT,. Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater, 2003 Jun 30; Vol 5:p.29-39;
Kaigler D, Avila G, Wisner-Lynch L, Nevins ML, Nevins M, Rasperini G, Lynch SE, Giannobile WV,. Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration. Expert Opin Biol Ther, 2011 Vol. 3:p 375-85.
Hou, R., Chen, F., Yang, Y., Cheng, X., Gao, Z., Yang, H. O., et al. Comparative study between coral-mesenchymal stem cells-rhBMP-2 composite and auto-bone-graft in rabbit critical-sized cranial defect model. Journal of Biomedical Materials Research, Part A, 2006. p 85-93.
Tabata, Y. Tissue Regeneration Based on Drug Delivery Technology , Institute for Frontier Medical Sciences, Kyoto University, 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, 2003, Japan.
Amini, A. R., Laurencin, C. T., & Nukavarapu, S. P. Bone tissue engineering: recent advances and challenges.Biomed Eng, 2012; 40(5): p.363–408.
Bauer, T. W., & Muschler, G. F. Bone graft materials: An overview of the basic science. Clin Orthop Relat Res, 2000 (371):p.10-27.
Torres, J., Tamimi, F., Alkhraisat, M., Frutos, J. P., & Cabarcos, E. L. Bone subtitutes. J. Implant Dentistry, 2011.
Enrione, J., Osorio, F., Lopez, D., Oppenheimer, C.W., & Fuentes, M.A. Characterization of a Gelatin/Chitosan/Hyaluronan scaffold-polymer. Electronic Journal of Biotechnology, 2010. Vol. 13. No. 5.
Gaikwad, V. V., Patil, A. B., & Gaikwad, M. V. Scaffold for Drug Delivery in Tissue Engineering.
International Journal of Pharmaceutical Science and Nanotechnology, 2008. Vol 1, p.113-122.
Hout, W. M., van der Molen, A. M., Breugem, C. C., Koole, R., & Van Cann, E. M. Reconstruction of the alveolar cleft: can growth factor-aided tissue engineering replace autologous bone grafting? A literature review and systematic review of results obtained with bone morphogenetic protein-2. ,Clin Oral Invest 5(3), 2011. p.297-303.
Liu, J. Dan Kerns, D. G., Mechanisms of Guided Bone Regeneration, The Open Dentistry Journal, 2014, 8 (Suppl 1-M3) 56-65,
Ana, I. D., Matsuya, S., and Ishikawa, K., Engineering of Carbonate Apatite Bone Substitute Based on Composition-Transformation of Gypsum and Calcium Hydroxide, Int. J. Communication, Network, and System Sciences, 2010, 10:4236.
Kim, David, M., Camelo, M., Nevins, M., Schupbach, P., Nevins, M., Alveolar Ridge Reconstraction with A Composite Alloplastic Biomaterial, The International Journal of Periodontics and Restorative Dentistry, Harvard School of Dental Medicine, 2012, Boston.
Kumar, P., Vinitha, B., Fathima, G., Bone Graft in Dentistry, J. Pharm Bioallied Sci. Juni 2013, 5: S125-S127.
Bouler, J.M., LeGeros R.Z., Daculsi G., , Biphasic Calcium Phosphates: Influence of Three Synthesis Parameters on The Ha/b-TCP Ratio, J. Biomed Mater Res, 2000,51:680-684.
O'Brien, F. J. Biomaterials and scaffold for tissue engineering. Anatony articles, 2011.
Tanimoto, Y., Nishiyama N., Preparation and Physical Propeerties of Tricalcium Phosphate Laminates for Bone-Tissue Engineering, J. Biomed Mater Res , 2008, A85: 427-433.