Analisis Bibliometrik Formulasi Poliherbal sebagai Afrodisiak: Tinjauan Tren Penelitian Terkini
DOI:
https://doi.org/10.36733/medicamento.v11i2.11418Kata Kunci:
afrodisiak, formulasi poliherbal, kesehatan seksual, kombinasi herbal, potensi terapeutikAbstrak
Dalam beberapa tahun terakhir, potensi terapeutik formulasi poliherbal sebagai afrodisiak, khususnya sebagai alternatif alami pengganti terapi sintetis untuk gangguan kesehatan seksual, telah menarik perhatian yang signifikan. Formulasi poliherbal diyakini meningkatkan efektivitas melalui efek sinergis, sehingga menjadi pilihan yang disukai baik dalam praktik pengobatan tradisional maupun modern. Tinjauan ini bertujuan memberikan analisis komprehensif mengenai tren penelitian terkait penggunaan formulasi poliherbal untuk tujuan afrodisiak. Analisis bibliometrik dilakukan menggunakan basis data Scopus dengan mengekstraksi artikel relevan menggunakan kata kunci “Aphrodisiac AND Polyherbal OR Combination”. Dari 88 artikel awal, 16 artikel dipilih untuk analisis mendalam. Perangkat lunak VOSviewer digunakan untuk memvisualisasikan jaringan kolaborasi, pola kepenulisan bersama, dan tren kata kunci, yang menunjukkan meningkatnya minat penelitian terhadap formulasi poliherbal untuk meningkatkan kesehatan seksual. Tinjauan naratif melengkapi temuan ini dengan mengeksplorasi metodologi penelitian, sumber bahan herbal, komposisi formulasi, dan tanaman yang paling sering digunakan. Hasil menunjukkan bahwa meskipun formulasi afrodisiak poliherbal memiliki potensi terapeutik yang menjanjikan, penelitian di bidang ini masih terfragmentasi dengan uji klinis yang terbatas terkait keamanan dan efektivitas. Tanaman yang paling sering diteliti meliputi Tribulus terrestris, Mucuna pruriens, dan Withania somnifera, yang dikenal berpengaruh terhadap kadar testosteron, fungsi vaskular, dan peningkatan libido. Formulasi afrodisiak poliherbal yang terdiri dari 2 hingga 41 spesies tanaman bekerja melalui mekanisme sinergis antar tanaman yang meningkatkan fungsi seksual dan mendukung kesehatan reproduksi secara komprehensif. Temuan ini memberikan wawasan penting bagi peneliti dan industri dalam pengembangan produk nutraseutikal dan farmaseutikal berbasis poliherbal.
Referensi
1. Leisegang K, Finelli R. Alternative medicine and herbal remedies in the treatment of erectile dysfunction: A systematic review. Arab J Urol. 2021;19(3):323-339. doi:10.1080/2090598X.2021.1926753
2. Ara I, Maqbool M, Bukhari B, Ara N, Hajam TA. Present Status, Standardization and Safety Issues with Herbal Drugs. Int J Res Pharm Sci Technol. 2020;1(3):95-101. doi:10.33974/ijrpst.v1i3.169
3. Karole S, Shrivastava S, Thomas S, et al. Polyherbal Formulation Concept for Synergic Action: A Review. J Drug Deliv Ther. 2019;9(1-s):453-466. doi:10.22270/jddt.v9i1-s.2339
4. Jeong JY, Jung IG, Yum SH, Hwang YJ. In Vitro Synergistic Inhibitory Effects of Plant Extract Combinations on Bacterial Growth of Methicillin-Resistant Staphylococcus aureus. Pharmaceuticals. 2023;16(10):1491. doi:10.3390/ph16101491
5. Parveen A, Zahiruddin S, Agarwal N, Siddiqui MA, Ansari SH, Ahmad S. Modulating effects of the synergistic combination of extracts of herbal drugs on cyclophosphamide-induced immunosuppressed mice. Saudi J Biol Sci. 2021;28(11):6178. doi:10.1016/j.sjbs.2021.06.076
6. Ainurofiq A, Wiyono N, Warni R, Choiri S. Assessment of the synergistic effect of a poly-herbals combination on the antioxidant activity through a statistical approach. F1000Research. 2023;11:1327. doi:10.12688/f1000research.126579.2
7. Partan RU, Hidayat R, Saleh MI. Potential efficacy of extracts of Pimpinela alpina, Tribulus terestris and Eurycoma longifolia in increasing sexual activity in male wistar rats. Med Plants. 2018;10(1):52-57. doi:10.5958/0975-6892.2018.00008.4
8. Sahoo HB, Nandy S, Senapati AK, Sarangi SP, Sahoo SK. Aphrodisiac activity of polyherbal formulation in experimental models on male rats. Pharmacogn Res. 2014;6(2):120-126. doi:10.4103/0974-8490.129029
9. Ara A, Vishvkarma R, Mehta P, Rajender S. The Profertility and Aphrodisiac Activities of Tribulus terrestris L.: Evidence from Meta-Analyses. Andrologia. 2023;2023(1):7118431. doi:10.1155/2023/7118431
10. Falagas ME, Pitsouni EI, Malietzis GA, Pappas G. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: strengths and weaknesses. FASEB J. 2008;22(2):338-342. doi:10.1096/fj.07-9492LSF
11. Rodríguez-Redondo Y, Denche-Zamorano A, Muñoz-Bermejo L, et al. Bibliometric Analysis of Nature-Based Therapy Research. Healthcare. 2023;11(9):1249. doi:10.3390/healthcare11091249
12. Musa TH, Musa IH, Osman W, Campbell MC, Musa HH. A bibliometric analysis of global scientific research output on Gum Arabic. Bioact Carbohydr Diet Fibre. 2021;25:100254. doi:10.1016/j.bcdf.2020.100254
13. Kang DY, Kim H, Kim KW, Chung WS. Bibliometric analysis of research relating to the use of herbal medicine for rheumatoid arthritis between 1991 to 2021. Medicine (Baltimore). 2022;101(37):e30413. doi:10.1097/MD.0000000000030413
14. Hou A, Yang L, Lü J, Yang L, Kuang H, Jiang H. A bibliometrics visualization analysis and hotspots prediction for natural product on osteoporosis research from 2000 to 2021. J Future Foods. 2022;2(4):326-337. doi:10.1016/j.jfutfo.2022.08.004
15. Kanase VG, Kini R, Maniyar D, Shettigar S. Effect of Advertised Polyherbal (Ayurvedic) Aphrodisiac Formulations on Potent Male Albino Rats. Asian J Pharm Clin Res. Published online May 7, 2020:51-53. doi:10.22159/ajpcr.2020.v13i5.36022
16. Sahin K, Tuzcu M, Orhan C, et al. MAT, a Novel Polyherbal Aphrodisiac Formulation, Enhances Sexual Function and Nrf2/HO-1 Pathway While Reducing Oxidative Damage in Male Rats. Evid-Based Complement Altern Med ECAM. 2018;2018:8521782. doi:10.1155/2018/8521782
17. Khan MB, Rathi BJ, Rajput D, Wanjari A. A review on classical Vajikarana formulations of Shweta Musali. J Indian Syst Med. 2019;7(4):205. doi:10.4103/JISM.JISM_67_19
18. Arletti R, Benelli A, Cavazzuti E, Scarpetta G, Bertolini A. Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats. Psychopharmacology (Berl). 1999;143(1):15-19. doi:10.1007/s002130050913
19. Udani JK, George AA, Musthapa M, Pakdaman MN, Abas A. Effects of a Proprietary Freeze-Dried Water Extract of Eurycoma longifolia (Physta) and Polygonum minus on Sexual Performance and Well-Being in Men: A Randomized, Double-Blind, Placebo-Controlled Study. Evid Based Complement Alternat Med. 2014;2014(1):179529. doi:10.1155/2014/179529
20. Mahajan GK, Mahajan AY, Mahajan RT. Efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males. J Complement Integr Med. 2012;9:Article 6. doi:10.1515/1553-3840.1520
21. Hsieh CH, Tsai HC, Hsu GL, Chen CC, Hsu CY. Herb formula enhances treatment of impotent patients after penile venous stripping: a randomised clinical trials. Andrologia. 2016;48(7):754-760. doi:10.1111/and.12508
22. Worp HB van der, Howells DW, Sena ES, et al. Can Animal Models of Disease Reliably Inform Human Studies? PLOS Med. 2010;7(3):e1000245. doi:10.1371/journal.pmed.1000245
23. Singh R, Ali A, Jeyabalan G, Semwal A, Jaikishan. An overview of the current methodologies used for evaluation of aphrodisiac agents. J Acute Dis. 2013;2(2):85-91. doi:10.1016/S2221-6189(13)60105-5
24. Tajudin T, Indratmoko S, Prawatya AN. Optimasi Formula Nanohydrogel Icariin Sebagai Afrodisiak.: Optimization of Icariin Nanohydrogel Formula as an Aphrodisiac. J Tumbuh Obat Indones. 2023;16(2):137-155. doi:10.31002/jtoi.v16i2.998
25. Kaspate D, Ziyaurrahman AR, Saldanha T, Kale P. Preclinical evaluation of Polyherbal Formulation for female sexual dysfunction. Int J Pharma Bio Sci. 2015;6(1):P639-P671.
26. Nouioura G, Lyoussi B, Derwich E. Rekindling desire: Unveiling the Aphrodisiac potential of Apiaceae Elixirs. Phytomedicine Plus. 2024;4(2):100530. doi:10.1016/j.phyplu.2024.100530
27. Vijayanarayana K, Rao PGM, Chacko N, Kishore GS, Udupa N. Aphrodisiac activity of geyenaphro: A poly herbal formulation in rats. Pharmacologyonline. 2010;1:607-613.
28. Nagaphani K, Khalid MdS, Gouda TS, et al. Effect of polyherbal formulation androcare, for its aphrodisiac activity. Pharmacologyonline. 2009;2:354-364.
29. Khan MB, Rathi BJ, Thakur SK. Evaluation of Spermatogenic Activity of Polyherbal Compound Musalyadi Churna and its Protective Effect Against Nicotine‑Induced Testicular Degeneration in Sprague–Dawley Rats. J Pharm Bioallied Sci. 2024;16(1):8-15. doi:10.4103/jpbs.jpbs_825_23
30. Gurav N, Gurav S, Wanjari M, Prasad S, Wayal S, Rarokar N. Development and evaluation of aphrodisiac potential of a classical ayurvedic formulation, ‘Kaamdev ghrita’ in rat model. J Ayurveda Integr Med. 2021;12(2):294-301. doi:10.1016/j.jaim.2020.09.007
31. Johri PK, Tripathi R, Johri R. Testicular protein profile(SDS-PAGE) study of tested reversibile male antifertility and aphrodisiac polyherbal preparation fed albino rats with special reference to zinc deficiency. Biochem Cell Arch. 2013;13(2):277-279.
32. Bojja SL, Kolathur KK, Chaudhari BB, et al. Poweromin X Ten, a polyherbal formulation improves male sexual function: In vivo and network pharmacology study. F1000Research. 2024;13:260. doi:10.12688/f1000research.145889.2
33. Ara A, Vishvkarma R, Mehta P, Rajender S. The Profertility and Aphrodisiac Activities of Tribulus terrestris L.: Evidence from Meta-Analyses. Andrologia. 2023;2023(1):7118431. doi:10.1155/2023/7118431
34. Nipanikar S, Nagore D, Chitlange S. Evaluation of aphrodisiac activity of AHPL/AYCAP/0114 capsule in sexually sluggish male rats. Pharmacogn Mag. 2018;14(55):S264-S267. doi:10.4103/pm.pm_363_17
35. Suresh S, Prakash S. Effect of Mucuna pruriens (Linn.) on sexual behavior and sperm parameters in streptozotocin-induced diabetic male rat. J Sex Med. 2012;9(12):3066-3078. doi:10.1111/j.1743-6109.2010.01831.x
36. Sahin K, Orhan C, Akdemir F, et al. Comparative evaluation of the sexual functions and NF-κB and Nrf2 pathways of some aphrodisiac herbal extracts in male rats. BMC Complement Altern Med. 2016;16(1):318. doi:10.1186/s12906-016-1303-x
37. Chauhan S, Srivastava MK, Pathak AK. Effect of standardized root extract of ashwagandha (Withania somnifera) on well-being and sexual performance in adult males: A randomized controlled trial. Health Sci Rep. 2022;5(4):e741. doi:10.1002/hsr2.741
38. Nasimi Doost Azgomi R, Zomorrodi A, Nazemyieh H, et al. Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence. BioMed Res Int. 2018;2018:4076430. doi:10.1155/2018/4076430
39. Tajuddin null, Ahmad S, Latif A, Qasmi IA. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. & Perry. (clove) in male mice: a comparative study. BMC Complement Altern Med. 2003;3:6. doi:10.1186/1472-6882-3-6
40. Tajuddin null, Ahmad S, Latif A, Qasmi IA, Amin KMY. An experimental study of sexual function improving effect of Myristica fragrans Houtt. (nutmeg). BMC Complement Altern Med. 2005;5:16. doi:10.1186/1472-6882-5-16
41. Bansode FW, Arya KR, Singh RK, Narender T. Dose-dependent effects of Asparagus adscendens root (AARR) extract on the anabolic, reproductive, and sexual behavioral activity in rats. Pharm Biol. 2015;53(2):192-200. doi:10.3109/13880209.2014.913295
42. Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine Int J Phytother Phytopharm. 2001;8(5):401-409. doi:10.1078/0944-7113-00060
43. Abushammala IM. INTERACTION OF SILDENAFIL WITH HERBAL SUPPLEMENTS: A REVIEW. Bull Pharm Sci Assiut Univ. 2021;44(2):291-300. doi:10.21608/bfsa.2021.207145
44. Senthilkumaran S, Balamurugan N, Suresh P, Thirumalaikolundusubramanian P. Priapism, pomegranate juice, and sildenafil: Is there a connection? Urol Ann. 2012;4(2):108-110. doi:10.4103/0974-7796.95560
45. Kunle, Folashade O, Egharevba, Omoregie H, Ahmadu, Ochogu P. Standardization of herbal medicines - A review. Int J Biodivers Conserv. 2012;4(3):101-112. doi:10.5897/IJBC11.163
46. Bhairam M, Roy A, Bahadur S, Banafar A, Turkane D. Standardization of Herbal Medicines – an Overview. J Appl Pharm Res. 2013;1(1):14-21.
47. Rani S, Manju SL. Formulation and Standardization of Polyherbal Antihyperlipidemic Formulation. J Nat Remedies. 2021;20(4):228. doi:10.18311/jnr/2020/24795

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