Retrospective Study of Antibiotic Use in Covid-19 Patients with Pneumonia at Hospital “X” Bali Province, Indonesia
DOI:
https://doi.org/10.36733/medicamento.v10i1.7637Keywords:
antibiotic, COVID-19, PCNE, PSIAbstract
COVID-19 with bacterial pneumonia co-infection is a condition with bacteria present in COVID-19 patients. The prevalence of bacterial co-infection in COVID-19 patients ranges from 12.4%–50%. This study aims to determine the relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection at Hospital "X" Bali Province, Indonesia. This research is an observational study with a cross-sectional approach. Data collection was carried out retrospectively on medical record data of COVID-19 inpatients with pneumonia co-infection at Hospital "X" Bali Province, Indonesia for the period January - December 2021. The sampling technique used total sampling according to inclusion and exclusion criteria. Appropriate use of antibiotics antibiotic was analyzed using Pharmaceutical Care Network Europe (PCNE) version 9.1. The patient severity index was an assessment based on the Pneumonia Severity Index (PSI) score. The relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection was analyzed using Fisher's test. Of the 80 COVID-19 inpatients with pneumonia co-infection, 90% experienced inappropriate use of antibiotics. Fisher's test results showed that there was no significant relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection at Hospital "X" Bali Province, Indonesia (p > 0.05).
References
Osman M, Manosuthi W, Kaewkungwal J, et al. Etiology, Clinical Course, and Outcomes of Pneumonia In The Elderly: A Retrospective and Prospective Cohort Study In Thailand. American Journal of Tropical Medicine and Hygiene. 2021;104(6):2009-2016. doi:10.4269/ajtmh.20-1393
Torres A, Cilloniz C, Niederman MS, et al. Pneumonia. Nature Reviews Disease Primers. 2021;7(1). doi:10.1038/s41572-021-00259-0
Alipoor SD, Jamaati H, Tabarsi P, Mortaz E. Immunopathogenesis of Pneumonia in Covid-19. Tanaffos. 2020;19(2):79-82.
Alqahtani A, Alamer E, Mir M, et al. Bacterial Coinfections Increase Mortality of Severely Ill COVID-19 Patients in Saudi Arabia. International Journal of Environmental Research and Public Health. 2022;19(4). doi:10.3390/ijerph19042424
Bazaid AS, Barnawi H, Qanash H, et al. Bacterial Coinfection and Antibiotic Resistance Profiles among Hospitalised COVID-19 Patients. Microorganisms. 2022;10(3):1-12. doi:10.3390/microorganisms10030495
Zhu X, Ge Y, Wu T, et al. Co-infection with Respiratory Pathogens Among COVID-2019 Cases. Virus Research. Published online 2020:1-6. doi:doi: 10.1016/j.virusres.2020.198005
PDPI. Pneumonia Covid-19 Diagnosis & Penatalaksanaan Di Indonesia. Perhimpunan Dokter Paru Indonesia, Jakarta; 2020.
Satici C, Demirkol MA, Sargin Altunok E, et al. Performance of Pneumonia Severity Index and CURB-65 in Predicting 30-day Mortality in Patients with COVID-19. International Journal of Infectious Diseases. 2020;98:84-89. doi:10.1016/j.ijid.2020.06.038
Usman DAP, Herman H, Emelda A. Evaluasi Penggunaan Antibiotika Terhadap Pasien Pneumonia Komuniti Di Rumah Sakit Ibnu Sina Makassar. Jurnal Ilmiah As-Syifaa. 2014;6(1):61-72. doi:10.33096/jifa.v6i1.34
Simanjuntak T, Nisa Berawi K. Kejadian Drug Related Problems (DRPs) pada Pasien Penderita Pneumonia Komuniti Berdasarkan Panduan PDPI (Perhimpunan Dokter Paru Indonesia) di Poliklinik Paru RSUD Jendral Ahmad Yani Periode April 2014−Maret 2015 Kota Metro. Medula. 2017;7(5):54-61.
Anggraini W. Evaluasi Kualitatif Penggunaan Antibiotik Pada Pasien Pneumonia Rs “X’’ Di Malang. KELUWIH: Jurnal Kesehatan dan Kedokteran. 2021;3(1):9-21. doi:10.24123/kesdok.v3i1.2887
Presley B, Presley B, Setiabudi I. The Influence of Pharmaceutical Care Intervention on Inpatient Community Acquired Pneumonia: A Small Randomized Single Blind Study. Jurnal Sains Farmasi & Klinis. 2015;2(1):84-90.
Kurniawan AH, Puspita N, Meitinawati TI, Lestiani L. Pengkajian Terapi COVID-19 Pada Pasien Rawat Inap Komorbid Hipertensi Terhadap Derajat Keparahan Penyakit di RSJPD Harapan Kita. JPSCR: Journal of Pharmaceutical Science and Clinical Research. 2022;7(2):132. doi:10.20961/jpscr.v7i2.53739
Xiang Y, Yu D, Qin X, Li X, Zhang Q. Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia. Journal of Xi’an Jiaotong University (Medical Sciences). 2020;41(4):492-496. doi:10.7652/jdyxb202004005
Hu C, Li J, Xing X, Gao J, Zhao S, Xing L. The Effect of Age on the Clinical and Immune Characteristics of Critically Ill Patients with COVID-19: A Preliminary Report. PLOS ONE. 2021;16(3):e0248675. doi:10.1371/JOURNAL.PONE.0248675
Fernández A, Gómez F, Curcio CL, Pineda E, de Souza JF. Prevalence and Impact of Potentially Inappropriate Medication on Community Dwelling Older Adults. Biomedica. 2020;41(1):1-30. doi:10.7705/biomedica.5787
Amer S, van Bree SH. Community-Acquired Pneumonia. Anaesthesia and Intensive Care Medicine. 2022;23(10):613-619. doi:10.1016/j.mpaic.2022.07.001
Wiyati T, Irawati D, Budiyono II. Studi Efek Samping Obat dan Penanganannya Pada Pasien TB Paru di Puskesmas Melong Asih, Cimahi. Pharmaceutical Science and Technology. 2014;III(1):23-30.
Rumende CM, Chen LK, Karuniawat A, et al. Hubungan Antara Ketepatan Pemberian Antibiotik Berdasarkan Alur Gyssens dengan Perbaikan Klinis Pasien pada Pneumonia Komunitas. Jurnal Penyakit Dalam Indonesia. 2019;6(2):71. doi:10.7454/jpdi.v6i2.335
Tolossa T, Wakuma B, Gebre DS, et al. Time to Recovery From COVID-19 and Its Predictors Among Patients Admitted to Treatment Center of Wollega University Referral Hospital (WURH), Western Ethiopia: Survival Analysis of Retrospective Cohort Study. PLoS ONE. 2021;16(6 June):1-12. doi:10.1371/journal.pone.0252389
Mengist B, Tesfa M, Kassie B. Time to Recovery and Predictors of Severe Community-Acquired Pneumonia Among Pediatric Patients in Debre Markos Referral Hospital, North West Ethiopia: A Retrospective Follow-up study. PLoS ONE. 2020;15(9 September):1-15. doi:10.1371/journal.pone.0239655
Sitompul PA, Indriani R, Maemun S, et al. Length of Stay of Pneumonia Patients Associated With Comorbid and Complications Factors in Referral National Infectious Diseases Hospital. Tanzania Journal of Health Research. 2023;24(1):1-5. doi:10.4314/thrb.v24i1.8
Deli H, Rasyid TA, Refki M. Hubungan antara Status Nutrisi dan Penggunaan Alat Bantu Nafas pada Pasien di ICU. Jurnal Ilmiah Keperawatan Indonesia [JIKI]. 2018;2(1):1. doi:10.31000/jiki.v2i1.206
Rumawas ME. Peran Faktor Nutrisi Pada Imunitas Dan Fungsi Proteksi Terhadap Infeksi Virus SARS COV-2 (COVID-19). Fakultas Kedokteran Untar. Published online 2021:1-14.
Nainar AAA, Nuraeni E, Setyawati D. Tingkat Kecemasan dan Faktor Genetik dengan Kejadian Hipertensi pada Lanjut Usia Di Posbindu Puskesmas Cipondoh Kota Tangerang. Jurnal Ilmiah Keperawatan Indonesia (JIKI). 2019;3(1):119-131.
Tanjung AI, Neherta M, Sarfika R. Faktor-faktor yang Berhubungan dengan Kekambuhan Orang dengan Skizofrenia yang Berobat di Poli-Klinik Rumah Sakit Jiwa Prof. Dr. Muhammad Ildrem Medan Tahun 2021. Jurnal Ilmiah Universitas Batanghari Jambi. 2022;22(1):432. doi:10.33087/jiubj.v22i1.2170
Tufa A, Gebremariam TH, Manyazewal T, et al. Inflammatory Mediators Profile in Patients Hospitalized with COVID-19: A Comparative Study. Frontiers in Immunology. 2022;13(July):1-14. doi:10.3389/fimmu.2022.964179
Fathi F, Sami R, Mozafarpoor S, et al. Immune System Changes During COVID-19 Recovery Play Key Role in Determining Disease Severity. International Journal of Immunopathology and Pharmacology. 2020;34. doi:10.1177/2058738420966497
Zhan Y, Zhu Y, Wang S, et al. SARS-CoV-2 Immunity and Functional Recovery of COVID-19 Patients 1-year After Infection. Signal Transduction and Targeted Therapy. 2021;6(1):1-12. doi:10.1038/s41392-021-00777-z
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