Sunscreen Activity Assays of an Emulgel Formulation Containing Nanoencapsulated Ipomoea batatas L. (Antin-3 Variety) Leaf Extract
DOI:
https://doi.org/10.36733/medicamento.v11i2.11725Keywords:
Antin-3 Nanocapsule, Emulgel, Erythema, Pigmentation, SPFAbstract
Flavonoids in purple sweet potato leaf extract (Ipomoea batatas (L.)) variety Antin-3 (Antin-3 extract) have properties as sunscreen. Flavonoids have a large molecular weight and easily decomposed by light, high temperature and external environmental. Modification of Antin-3 extract, namely nanoencapsulation with chitosan: NaTPP, is needed to reducing size and protect flavonoids so that they can remain in the skin layers longer to provide sunscreen protection. This study aims to formulate Antin-3 extract nanoencapsulation into emulgel sunscreen preparations and measure sunscreen activity through SPF, erythema and pigmentation values. The samples tested were base: Antin-3 nanoencapsulation of 0.3%: 0.6% and 0.9% = Base: F1: F2: F3. The results of the physical characteristics test of pH were respectively 6.39 ± 0.04: 5.98 ± 0.28: 5.62 ± 0.25: 5.3 ± 0.42 (sig 0.027 < 0.05) and the spreadability test were respectively 5.91 ± 0.17: 5.89 ± 0.15: 6.08 ± 0.31: 6.28 ± 0.16 (sig 0.266 > 0.05). For the SPF value respectively were 7.48 ± 0.01: 21.03 ± 0.03: 38.02 ± 0.10: 38.29 ± 0.07 (sig 0.00 < 0.05). Based samples has a weak protection, Antin-3 extract emulgel of 0.3% has a medium protection and Antin-3 extract emulgel of 0.6% and 0.9% have a high protection category. All of emulgel sunscreen has the ability to protect the skin from redness and pigmentation due to UV exposure.
References
1. Himawan HC, Masaenah E, Putri VCE. Aktivitas Antioksidan dan SPF Sediaan Krim Tabir Surya dari Ekstrak Etanol 70% Kulit Buah Pisang Ambon (Musa acuminata Colla). J Farmamedika (Pharmamedika Journal). 2018;3(2):73-81.
2. Prasiddha IJ, Laeliocattleya RA, Estiasih T. Potensi senyawa bioaktif rambut jagung (zea mays L) untuk tabir surya alami : Kajian Pustaka. J Pangan dan Agroindustri. 2016;4(1):40-45.
3. Dipahayu, Damaranie; Gondo Kusumo G. Antioxidant Activity, Phenolic and Flavonoid Contents in The Leaves Extract of Purple Sweet Potatoes (Ipomoea bataats (L.) Antin-3 Variety in Variety in Different Ethanol Concentration as a Solvent. 3 rd Jt Conf Unair-USM, Int Conf Pharm Heal Sci 2020 Non Proc. Published online 2020.
4. Dipahayu D. Formulation Sunscreen Emulgel of Sweet Potatoes Leaves Extract (Ipomoea batatas (L.)) Antin-3 Variety. J Pharmasci (Journal Pharm Sci. 2020;5(2):49-54. doi:10.53342/pharmasci.v5i2.174
5. Cefali LC, Franco JG, Nicolini GF, Ataide JA, Mazzola PG. In vitro antioxidant activity and solar protection factor of blackberry and raspberry extracts in topical formulation. J Cosmet Dermatol. 2019;18(2):539-544. doi:10.1111/jocd.12842
6. Putri AI, Sundaryono A, Chandra IN. KARAKTERISASI NANOPARTIKEL KITOSAN EKSTRAK DAUN UBIJALAR (Ipomoea batatas L.) MENGGUNAKAN METODE GELASI IONIK. Alotrop. 2019;2(2):203-207. doi:10.33369/atp.v2i2.7561
7. Gondo Kusumo G, Dipahayu D. Artikel Penelitian The Effect of Nano Extract Formulation on Antioxidant Activity of 70% Ethanolic Extract of Purple Sweet Potato’s Leaves (Ipomoea batatas L.) Antin-3 Variety. J Pharmasci (Journal Pharm Sci. 2022;7(1).
8. Hasbiah SN, Apriyana AEP, Dipahayu D. Formulasi dan Uji Stabilitas Fisik Krim Tabir Surya Nanoenkapsul Ekstrak DaunUbi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3. J Sains dan Kesehat. 2024;5(5):716-722. doi:10.30872/jsk.v5i5.583
9. Suena NMDS, Rahayu LRP, Wijaya SC, Antari NPU, Adrianta KA. Formulation and Antioxidant Activity Test of Centella asiatica Herba Extract and Moringa oleifera Leaves Extract as An Anti-Aging Emulgel. Trop J Nat Prod Res. 2024;8(3):6525-6536. doi:10.26538/tjnpr/v8i3.9
10. Yulianti E, Adelsa A, Putri A. Penentuan nilai SPF (Sun Protection Factor) Ekstrak Etanol 70 % Temu Mangga (Curcuma mangga) dan Krim Ekstrak Etanol 70 % Temu Mangga (Curcuma mangga) secara In VitroMenggunakan Metode Spektrofotometri. Maj Kesehat FKUB. 2015;2(1):41-50.
11. Kulsum U, Saraswati R, Fitri ACK, Widyastuti FK. Optimasi Waktu Maserasi dan Jenis Pelarut Terhadap Kadar Flavonoid pada Ekstrak Daun Sirsak (Annona Muricata L). Pros SENTIKUIN (Seminar Nas Teknol Ind Lingkung dan Infrastruktur). 2019;2:C17-1.
12. Maulida AN. Uji Efektivitas ( Curcuma Heyneana Val. ) Sebagai Tabir Surya Secara In Vitro.; 2015.
13. Aulia D. Formulasi Emulgel Tabir Surya Nanopartikel Seng Oksida Dengan Variasi Konsentrasi Carbopol 934 Sebagai Gelling Agent dan Natrium Lauril Sulfat Sebagai Surfaktan. Univ Muhammadiyah Surakarta. Published online 2018:1-12.
14. Pratama WA, Zulkarnain AK. Uji SPF In Vitro dan Sifat Fisik Beberapa Produk Tabir Surya yang Beredar di Pasaran. Maj Farm. 2015;11(1):275-283.
15. Di Lorenzo C, Colombo F, Biella S, Stockley C, Restani P. Polyphenols and human health: The role of bioavailability. Nutrients. 2021;13(1):1-30. doi:10.3390/nu13010273
16. Forestryana D, Hidayah S, Saputri R, Ramadhan H. Studi Formulasi, Stabilitas dan Efektivitas Gel Hand Sanitizer Ekstrak Etanol 80% Akar Kayu Kuning (Arcangelisia flava (L.) Merr.). J Ilmu Kefarmasian Indones. 2022;20(2):201. doi:10.35814/jifi.v20i2.1281
17. Paul SP. Ensuring the Safety of Sunscreens, and Their Efficacy in Preventing Skin Cancers: Challenges and Controversies for Clinicians, Formulators, and Regulators. Front Med. 2019;6(September):1-7. doi:10.3389/fmed.2019.00195
18. Fauziyyah RNP, Komariah M, Herliani YK. Sunlight Exposure and Protection Behavior as Prevention of Skin Cancer in Nursing Students. Indones J Cancer. 2023;17(1):1. doi:10.33371/ijoc.v17i1.921
19. Ghazi S. Do the polyphenolic compounds from natural products can protect the skin from ultraviolet rays? Results Chem. 2022;4(June):100428. doi:10.1016/j.rechem.2022.100428
20. Farhan M. The Promising Role of Polyphenols in Skin Disorders. Molecules. 2024;29(4):1-35. doi:10.3390/molecules29040865
21. Pasha FF. Kajian Bahan Alam Berpotensi Sebagai Tabir Surya. J Ilm Farm. 2021;11(1):1-14.
22. Abdlaty R, Hayward J, Farrell T, Fang Q. Skin erythema and pigmentation: a review of optical assessment techniques. Photodiagnosis Photodyn Ther. 2021;33:102127. doi:10.1016/j.pdpdt.2020.102127
23. Passeron T, Lim HW, Goh CL, et al. Photoprotection according to skin phototype and dermatoses: practical recommendations from an expert panel. J Eur Acad Dermatology Venereol. 2021;35(7):1460-1469. doi:10.1111/jdv.17242
24. Gina Yustika Rijar, Nurmala Sari, Ahmad Irsyad Aliah. Comparison of Percent Value of Erythema and Pigmentation Transmission with Maceration and Infusion Method of Robusta Coffee (Coffea Canephora Pierre A. Frohner) Derived from the District Tana Toraja. J Multidisiplin Madani. 2022;2(6):2729-2742.
25. Tasya SC, Kustiawan PM. Bioactivity of Purple Sweet Potato (Ipomea batatas) as Anti Inflammatory Agent: Review. J Syifa Sci Clin Res. 2023;5(1):91-100. doi:10.37311/jsscr.v5i1.14240
26. Advaita N, Guswinda Lestari R, Umar Aidid K, Sasongko H. In vitro evaluation of sun protection factor of vasconcellea pubescens fruit extract. In: International Conference on Pharmaceutical Research and Practice. ; 2018:122-125.
27. Aris M, Adriana, Andi Nur I. Penentuan Kadar Total Flavonoid dan Nilai SPF (Sun Protection Factor) Ekstrak Etanol Rimpang Temu Ireng (Curcuma aeruginosa Roxb.) secara Spektrofotometri UV-Vis. Fito Med J Pharm Sci. 2022;12(2):2022. http://journal.unpacti.ac.id/index.php/fito
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Copyright (c) 2025 Damaranie Dipahayu, Daffa Sachio Adenka, Jefri Ilyasa Srianto, Novita Dwi Astutik
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