Formulation of Combination Shampoo with Extract of Pandan Wangi Leaves (Pandanus amaryllifolius Roxb) and Celery Leaves (Apium graveolens L.) as Antidandruff Against Candida Albicans Fungus
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DOI:
https://doi.org/10.36733/usadha.v2i4.7382Keywords:
candida albicans, celery leaves, dandruff, pandan wangi leaves, shampooAbstract
Dandruff is a scalp condition characterized by an anomaly, often caused by the fungus of Candida albicans. The development of safe and effective anti-dandruff shampoo is imperative. Notably, traditional medicine employs pandan wangi and celery leaves, rich in polyphenols, flavonoids, saponins, tannins and alkaloids as potential anti-dandruff agents. The aims of this study was to formulate and evaluate the antifungal activity of a combination shampoo containing extracts form pandan wangi and celery leaves. Antifungal testing was carried out using the diffusion method using paper discs. Three formulations were prepared FI (without extract), FII (10% pandan leaf extract, 20% celery leaf), FIII (20% pandan leaf extract, 10% celery leaf). Antifungal test was evaluated using the paper disc diffusion method, with 2% ketoconazole shampoo as the positive control. Physical quality test demonstrated favorable attributes for pandan wangi and celery leaf extract shampoo, with FII and FIII exhibiting dark green colors whit distinct odors, while FI remained colorless and odorless. Furthermore, all formulations were in semi-solid dosage forms and met pH requirement for scalps (pH 6,) and produced satisfactory foam yields (6,8-8,9 cm). The antifungal activity test revealed FI as the negative control with a 7 mm and 2% ketoconazole shampoo with a 24 mm inhibition zone, while FII and FIII showed no inhibition zone. The combination of pandan wangi and celery leaf extract in shampoo preparation showed no synergic activity to inhibit the growth of Candida albicans fungus. Further investigations and clinical trials are warranted to validate its effectiveness and safety for practical application.
References
T. C. Malonda, P. V. Y. Yamlean, and G. Citraningtyas, “Formulasi Sediaan Sampo Antiketombe Ekstrak Daun Pacar Air (Impatiens Balsamina L.) Dan Uji Aktivitasnya Terhadap Jamur Candida Albicans Atcc 10231 Secara In Vitro,” vol. 6, no. 4, 2017.
S. W. Nielma Auliah, Muhammad Asri.SR, “Formulasi dan Uji Stabilitas Fisik dan Kimia sediaan shampo Antiketombe Ekstrak Kulit Buah Jeruk Purut (Citrus hystrix Dc),” vol. 151, pp. 10–17, 2015.
G. N. Mardiana and C. I. N. H. Safitri, “Formulasi Dan Uji Aktivitas Sediaan Gel Shampoo Antiketombe Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Candida Albicans,” Semin. Nas. Pendidik. Biol. dan Saintek, no. 2010, pp. 630–640, 2020.
A. R. Saraswati and N. A. Putriana, “Formulasi Shampo Anti Ketombe dan Anti Kutu Rambut dari Berbagai Macam Tanaman Herbal,” Farmaka, vol. 15, no. 1, pp. 248–260, 2013.
H. Hutauruk, P. V. Y. Yamlean, and W. Wiyono, “Formulasi Dan Uji Aktivitas Sabun Cair Ekstrak Etanol Herba Seledri (Apium Graveolens L) Terhadap Bakteri Staphylococcus Aureus,” Pharmacon, vol. 9, no. 1, p. 73, 2020, doi: 10.35799/pha.9.2020.27412.
D. J. Oktaviani, S. Widiyastuti, D. A. Maharani, A. N. Amalia, A. M. Ishak, and A. Zuhrotun, “Review: Seledri Apium Graveolens. Linn. Sebagai Tablet Anti-Inflamasi,” Farmaka, vol. 18, no. 1, pp. 1–15, 2020.
A. Mardiyaningsih and R. Aini, “Pengembangan Potensi Ekstrak Daun Pandan (Pandanus Amaryllifolius Roxb) Sebagai Agen Antibakteri,” Pharmaciana, vol. 4, no. 2, 2014, doi: 10.12928/pharmaciana.v4i2.1577.
N. Nining, N. S. Radjab, and N. Kholifah, “Kombinasi Trietanolamin Stearat Dan Setilalkohol Dalam Stabilitas Fisik Krim M/A Ekstrak Psidium Guajava L.,” Sci. J. Farm. dan Kesehat., vol. 9, no. 1, p. 17, 2019, doi: 10.36434/scientia.v9i1.188.
E. Nurhikma, D. Antari, and S. A. Tee, “Formulasi Sampo Antiketombe Dari Ekstrak Kubis (Brassica oleracea Var. Capitata L.) Kombinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb),” J. Mandala Pharmacon Indones., vol. 4, no. 1, pp. 61–67, 2018, doi: 10.35311/jmpi.v4i1.25.
M. B. Sitompul, P. V. Y. Yamlean, and N. S. Kojong, “Formulasi Dan Uji Aktivitas Sediaan Sampo Antiketombe Ekstrak Etanol Daun Alamanda (Allamanda Cathartica L.) Terhadap Pertumbuhan Jamur Candida Albicans Secara,” vol. 5, no. 3, pp. 122–130, 2016.
B. A. Maharataranti N, I.Y. Astuti., “Formulasi shampo antiketombe ekstrak etanol seledri (Apium graveolens L),” J. Pharm., vol. 9, no. 2, pp. 128–138, 2012.
N. V. Wendersteyt, D. S. Wewengkang, and S. S. Abdullah, “Uji Aktivitas Antimikroba Dari Ekstrak Dan Fraksi Ascidian Herdmania Momus Dari Perairan Pulau Bangka Likupang Terhadap Pertumbuhan Mikroba Staphylococcus Aureus, Salmonella Typhimurium Dan Candida Albicans,” Pharmacon, vol. 10, no. 1, p. 706, 2021, doi: 10.35799/pha.10.2021.32758.
K. Anwar, F. Istiqamah, and S. Hadi, “Optimasi Suhu dan Waktu Ekstraksi Akar Pasak Bumi (Eurycoma longifolia jack.) Menggunakan Metode RSM (response surface methodology) dengan Pelarut Etanol 70%,” J. Pharmascience, vol. 8, no. 1, p. 53, 2021, doi: 10.20527/jps.v8i1.9085.
H. M. Damayanti, N. A. Praditia, and R. W. Murti, “Ekstraksi Biji Alpukat Sebagai Pembusa Deterjen: "Pemanfaatan Potensi Bahan Alam dan Menekan Biaya Produksi,” vol. 3, no. 2013, pp. 92–98, 2015.
I. Duma et al., “Aktivitas Antibakteri dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau ( Piper betle L . ) Sebagai Alternatif Pengobatan Mastitis Sapi Antibacterial Activity and Physical Evaluation of Piper betle L . Decoction Gel as an Alternative Treatment for Masti,” vol. 16, no. 2, pp. 202–210, 2020, doi: 10.22146/farmaseutik.v16i2.53793.
patrick J. Sinko, Martin’s Physical Pharmacy and Pharmacetical Science. 2016.
R. C. Rowe, P. J. Sheskey, and S. C. Owen, Handbook of Pharmaceutica Excipients. 2009.
