• Raziv Ganesha Bagian Penyakit Mulut, Fakultas Kedokteran Gigi Universitas Mahasaraswati Denpasar
  • Dwi Setyaningtyas Spesialis Penyakit Mulut, Departemen Gigi & Mulut, Rumah Sakit Angkatan Laut (RSAL) Dr Ramelan
  • Diah Savitri E Departemen Penyakit Mulut Fakultas Kedokteran Gigi Universitas Airlangga Surabaya
  • Priyo Hadi Departemen Penyakit Mulut Fakultas Kedokteran Gigi Universitas Hasanuddin Makassar
  • Israyani


Introduction : Herpes simplex virus (HSV) is one variant of the herpes virus that infects humans, has two main types of HSV-1 that manifests more found in the mucosa of the mouth, pharynx, and skin (upper waist), and the type HSV-2 manifests in the genital area (lower waist). Case: 16-year-old female patient were referred from dermatologis RSAL Dr Ramelan Surabaya with complaints of many ulcers, whitish area of the tongue, palatum, vestibulum and genitals. Case Treatment: patients treated with systemic drugs of acyclovir, fluconazole, folic acid, vitamin B, vitamin C, methyl prednisolone, aloe vera extract topical. Patients were tested for blood, HSV-1 & HSV-2 (+), HIV (-), ANA (-). Discussion: Herpes simplex infection is a disease caused by the herpes simplex virus (HSV) which is a DNA virus (Deoxyribonucleic acid). In humans, the herpes virus can be latent and reactivate Reactivation can occur because of a trigger in the form of decreased immunity due to weather changes, fever, sun exposure, emotional stress, trauma, pregnancy, hormonal, systemic diseases, allergies, and immunosuppression. In this case the cause is thought to be due to hormonal. The diagnosis of primary HSV infection and recurrent infection is usually obtained from clinical features and laboratory tests are used establish the diagnosis. Conclucion: Recurrence of HSV infection can be reduced if avoid trigger factors. HSV infection management aimed at the control of pain, supportive treatment and definitive treatment. In this case, multidisciplinary collaboration is required in the treatment because it involves two sites, oral and genital.

Keyword : HSV, Recurrent Herpes Oral, Oral Candidiasis


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Kumar,V., Abbas, A. & Aster,J.C., 2015. Robbins and Cotran: Pathologic Basis of Disease 9th Ed. william schmitt, ed., Philadelphia: Elseiver Ltd.

Scully,C.,2010. Medical Problems in Dentistry, Available at: http://discovery.ucl.ac.uk/ 166609/.

Samaranayake, L., 2012. Essential Microbiology for Dentistry 4th Ed. Alison Taylor, ed., Edinburg: Churchill Livingstone Elseiver Ltd

Glick M. Burket's Oral Medicine. 12th ed. Connecticut (USA): People's Medical Publishing House; 2015; p104-110

Flint, S.R., 2013. Herpes Simplex Virus infection.,1(october), pp.1–7.

WHO Update. Herpes Simplex 2017. Available at http://www.who.int/mediacentre /factsheets/fs400/en/

DeLong, L. & Burkhart, N.W., 2013. General and Oral Pathology for the Dental Hygienist 2nd Editio., Philadelphia: Lippincott Williams & Wilkins.

Khan, D., Ahmed, A. The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases. 2015. Front Immunol. 6: 635.

Guilliams, Thomas G, Edward, Lena. Chronic Stress and the HPA axix: Clinical Assesment and Therapeutic Considerations. 2010. A review of Natural& nutraceutical therapies for clinical practice.vol.9, No.2.p.1-11.

Noisakran, Sansanee, Hallford, Williams, Veress, Livia. Role of the Hypothalamic Pituitary Adrenal Axis and IL-6 in Stress-Induced Reactivation of Latent Herpes simplex Virus Type-1.The American Journal of Immunologists.1998. p.5441-5447

Salvaggio MR, Lutwick LI, Seenivasan M, Kumar S. Herpes simplex. Medscape. available at http://www.emedicine.medscape.com/article/218580-overview

Chamlin SL, Lawley LP. Perioral dermatitis. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ. 2008. Fitzpatrick's Dermatology in General Medicine. 7th ed. New York: McGraw Hill Medical, p.709-712

Alpsoy E. Behçet’s disease: Treatment of mucocutaneus lesions. Clin Exp Rheumatol. 2005; 23:532-9.

Mehta S, Zutshi V, Batra S, Tanwar R. A case of Behçet’s disease in pregnancy. JIACM. 2006; Vol. 7, No 3: p:236-8

Singh N, dan Colon Y. Patient education and self-advocacy: Questions and responses on pain management Behçet’s disease. J. Pain and Palliative Care Parmacotherapy. 2011; Vol.25 no 3. p.283-5.

Singal A, Chhabra N, Pandhi D, Rohatgi J. Behçet’s disease in India: A dermatological perspective. Indian Journal of Dermatology, Venereology, and Leprology. 2013;79(2): 199-204.

Kaneko F, Togashi A, Saito S, Sakuma H, Oyama N, Nakamura K,. Review article: Behcet disease (Adamantiades-Behcet's Disease). Clinical and Developmental Immunology. 2011; 2011: 1-7.

Shwetha BA, Vittal NI, Tasneem AF, Tushar P, Lari AAJ. Case report: Behçet’s disease. International Journal of Recent Trends in Science and Technology. 2014; 10(2):33-4.

Keogan MT. Clinical immunology review series: An approach to the patient with recurrent orogenital ulceration, including Behçet’s syndrome. Clin Exp Immunol.2009; 156(1): 1-11.

Sakane T, Takeno M, Suzuki N, Inaba G. Current concept Behçet’s disease. The New England Journal of Medicine. 1999; 341(17): 1284-91.

Arduino PG, Porter SR. Oral and perioral herpes simplex virus type I (HSV-I) infection : review of its management. Oral Dis. 2006; 12:254-70.

Regezi, J., Sciubba, J. & Jordan, R., 2015. Oral Pathology Clinical Pathologic Correlations, elsevier, p.1-6.

Lokanata MD. Pemakaian Glukokortikoid pada Pengobatan. 2006. Jakarta: EGC. p.8-13,15-40

Dewoto HR. 2012. Farmakologi dan Terapi. Ed 5. Jakarta: FKUI.p 283,505

Sitompul R. Kortikosteroid dalam Tata Laksana Uveitis: Mekanisme Kerja, Aplikasi Klinis, dan Efek Samping. 2011. J Indon Med Assoc. Vol 61. No 6. p 265-9

Almatsier, Sunita. 2004. Penuntun Diet edisi baru. Jakarta: PT Gramedia Pustaka Utama.

Wiryana, M. Nutrisi Pada Penderita Sakit Kritis. J Peny Dalam 2007.Vol. 8 No 2. p.176-186

How to Cite
Ganesha, R., Setyaningtyas, D., Savitri E, D., Hadi, P., & Israyani. (2020). TATALAKSANA RECURRENT INTRA ORAL HERPES DISERTAI CANDIDIASIS YANG DIRUJUK OLEH DERMATOLOGIST. Interdental: Jurnal Kedokteran Gigi, 16(1), 19-23. https://doi.org/10.46862/interdental.v16i1.794