The Potential of Betel (Piper betel L.) as Anti-Asthmatic
DOI:
https://doi.org/10.36733/usadha.v2i1.3510Keywords:
asma, evidence based herbal-medicine, sirih (Piper betel Linn), tanaman obatAbstract
Asma merupakan peradangan saluran napas kronik dengan indikasi adanya mengi, batuk, dan rasa sesak yang timbul berulang .Studi epidemiologi menunjukkan hubungan yang kuat antara asma dan infeksi dengan patogen pernapasan, termasuk virus pernapasan umum seperti rhinovirus, human respiratory syncytial virus, adenovirus, coronavirus dan virus influenza, serta bakteri dan jamur. Salah satu upaya dalam pengobatan asma dapat menggunakan tanaman obat seperti tanaman sirih (Piper betel L.). Sirih menunjukan beberapa aktivitas farmakologis seperti antioksidan, antibakteri dan antihistamin sehingga berpotensi untuk digunakan dalam terapi asma. Tujuan penulisan artikel review ini untuk mempelajari aktivitas tanaman sirih sebagai tanaman obat dalam terapi asma. Metode yang digunakan dalam penyusunan artikel review ini yaitu studi literatur melalaui beberapa basis data yang kemudian diskrining dengan beberapa kriteria. Hasil review menunjukan bahwa kejadian asma berkaitan erat dengan stress oksidatif yang terbentuk karena tingginya radikal bebas. Kandungan senyawa fenolik seperti chatecol dan allylpyrocatecol pada tanaman sirih berperan sebagai antioksidan yang menghambat timbulnya stress oksidatif. Selain itu tanaman sirih juga menunjukan aktivitas antibakteri terhadap bakteri pneumonia. Ekstrak etanolik dan minyak atsiri daun sirih juga secara signifikan menunjukan aktivitas penghambatan bronkospasme yang diinduksi histamine. Berdasarkan hasil dapat disimpulkan bahwa tanaman sirih dapat digunakan sebagai kandidat alternatif untuk pengembangan obat dalam penatalaksanaan asma.
References
Global Intiative For Asthma (GINA). Global Strategy for Asthma Management for Preventation; 2011
Soedarto. Alergi dan penyakit sistem imun. Jakarta: Sagung Set; 2012
Maciag MC, Phipatanakul W. Preventing the development of asthma: Stopping the allergic march. Curr. Opin. Allergy Clin. Immunol. 2019 Apr;19(2):161-168.
Rodríguez-Santos O, Olea-Zapata R, Vite-Juárez NE, Gonzales-Saravia CA, Rojas-Galarza RAl, Laurrabaquio-Miranda AM, Díaz-Zúñiga JA. Sensitization to penicillin allergens in patients suffering from allergic diseases. VacciMonitor. 2018; 27 (1) :16–21
Edward MR, Bartlett NW, Hussell T, Openshaw P, Johnston SL. The Microbiology Of Asthma. Nat Rev Microbiol. 2012 Jun 6; 10(7):459-71
Depkes RI. Riset Kesehatan Dasar 2013, Badan Penelitian Dan Pengembangan Kesehatan. Jakarta : Kementerian Kesehatan RI; 2012
Elfahmi, Woerdenbag H, Kayser O. Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use. J. Herb. Med. 2014 Jun; 4 (2): 51–73.
Heinrich M, Barnes J, Gibbons S, Williamson E. Fundamentals of Pharmacognosy and Phytotherapy. New York : Churchill Livingstone Elsevier; 2012
Bone K, Mills S. Principles and Practice of Phytotherapy, Second Edition. New York : Churchill Livingstone Elsevier; 2013
Noventi W, Novita C. Potensi Ekstrak Daun Sirih Hijau (Piper betle L.) sebagai Alternatif Terapi Acne Vulgaris. Majority. 2016; 5(1): 141- 142
Salehi B, Zakaria ZA, Gyawali R, et al. Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications. Molecules. 2019 Apr 7; 24(7):1364.
Duce-Gracia F, Sebastián-Ariño .A. Medicines and additives whose use may involve risk in the asthmatic patient. Med. Respir. 2013
Kaveti B, Tan L, Sarnnia, Kuan S, et al. Antibacterial Activity Of Piper betel Leaves. IJPTP. 2011 Jan; 2(3): 129-132.
Taukoorah U, Lall N, Mahomoodally F. Piper Betle L. (Betel Quid) Shows Bacteriostatic, Additive, and Synergistic Antimicrobial Action When Combined with Conventional Antibiotics. S. Afr. J. Bot. 2016 Jul; 105:133-140
Shah SK, Garg G, Jhade D, Patel N. Piper Betle: Phytochemical, Pharmacological and Nutritional Value in Health Management. Int. J. Pharm. Sci. Rev. Res. 2016 May-Jun; 38(2):181-189
Periyanayagam K, Jagadeesan M, Kavimani S, Vetriselvan T. Pharmacognostical and Phyto-Physicochemical Profile of the Leaves of Piper Betle L. Var Pachaikodi (Piperaceae). Asian Pac. J. Trop. Biomed. 2012 Feb; 2(2): S506-S510
Ali A, Lim XY, Wahida PF. The Fundamental Study of Antimicrobial Activity of Piper Betle Extract in Commercial Toothpastes. J. Herb. Med. 2018 Dec; 14:29-34
Kurnia D, Hutabarat GS, Windaryanti D, Herlina T, Herdiyati Y, Satari MH. Potential Allylpyrocatechol Derivatives as Antibacterial Agent Against Oral Pathogen of S. Sanguinis ATCC 10,556 and as Inhibitor of MurA Enzymes: In Vitro and in Silico Study. Drug Des Devel Ther. 2020 Jul 27; 14:2977-2985
Srinivasan R, Devi KR, Kannappan A, Pandian SK, Ravi AV. Piper Betle and Its Bioactive Metabolite Phytol Mitigates Quorum Sensing Mediated Virulence Factors and Biofilm of Nosocomial Pathogen Serratia Marcescens in Vitro. J. Pubmed. 2016. Dec 4;193:592-603.
Teanpaisan R, Kawsud P, Pahumunto N, Puripattanavong J. Screening for Antibacterial and Antibiofilm Activity in Thai Medicinal Plant Extracts against Oral Microorganisms. J. ScienceDirect. 2017 Apr; 7(2):172-177
Nayaka NMDMW, Sasadara MMV, Sanjaya DA, Yuda PESK, Dewi NLKAA, Cahyaningsih E, Hartati R. Piper betle (L): Recent Review of Antibacterial and Antifungal Properties, Safety Profiles, and Commercial Applications. Molecules. 2021 Apr 16;26(8):2321.
Abrahim NN, Kanthimathi MS, Abdul-Aziz A. Piper betle shows antioxidant activities, inhibits MCF-7 cell proliferation and increases activities of catalase and superoxide dismutase. BMC Complement Altern Med. 2012 Nov 15;12:220
Valle DL, Cabrera EC, Puzon JJM, Rivera WL. Antimicrobial Activities of Methanol, Ethanol and Supercritical CO2 Extracts of Philippine Piper Betle L. on Clinical Isolates of Gram Positive and Gram Negative Bacteria with Transferable Multiple Drug Resistance. PLoS One. 2016 Jan 7;11(1):e0146349.
Valle DL, Andrade JI, Puzon JJM, Cabrera EC, Rivera WL. Antibacterial Activities of Ethanol Extracts of Philippine Medicinal Plants against Multidrug-Resistant Bacteria. Asian Pac. J. Trop. Biomed. 2015 Jul; 5(7):532-540
Hajare R, Darvhekar VM, Shewale A, Patil V. Evaluation of antihistaminic activity of Piper betel leaf in guinea pig. Afr. J. Pharmacy Pharmacol. 2011 Mar; 5(2):113-117
Misra KH, Kodanda RB, Ranjita N, Bandyopadhyay M. Evaluation of antiasthmatic effect of ethanol Extract of Piper betle linn. Against histamine induced Bronchospasm in guinea pigs. International Int. j. basic appl. sci. 2014 Jan-Mar; 4 (1):67-73
Rekha VPB, Kollipara M, Gupta BRSSS, Bharath Y, Pulicherla KK. A Review on Piper betle L.: Nature’s Promising Medicinal Reservoir. Am. j. ethnomed. 2014 : 1(5): 276-289
Pradhan D, Sun KA, Pradhan DK, Biswasroy P. Golden Heart of the Nature: Piper betle L. J. pharmacogn. phytochem. 2013; 1(6) : 147-167
Al-Adhroey AH, Nor ZM, Al-Mekhlafi HM, Amran AA, Mahmud R. Antimalarial Activity of Methanolic Leaf Extract of Piper Betle L. Molecules. 2011 Jan; 16(1):107-118
Sengupta K, Mishra AT, Rao MK, Sarma KV, Krishnaraju AV, Trimurtulu G. Efficacy of an Herbal Formulation LI10903 Containing Dolichos Biflorus and Piper Betle Extracts on Weight Management. Lipids Health Dis. 2012 Dec 27; 11 : 176
Arambewela LSR, Arawwawala LDAM, Kumaratunga KG, Dissanayake DS, Ratnasooriya WD, Kumarasingha SP. Investigations on Piper Betle Grown in Sri Lanka. Pharmacogn Rev. 2011 Jul; 5(10):159-163
