EFFECT OF KECEMCEM TREE (SPONDIAS PINNATA) BARK EXTRACT GEL TO INCREASE COLLAGEN POST WISTAR RATS CURETTAGE

Authors

  • Eka Pramudita Ramadhany Universitas Udayana
  • Media Sukmalia Adibah Universitas Udayana
  • Astrid Rahayu Dewi Universitas Udayana

DOI:

https://doi.org/10.46862/interdental.v19i2.6686

Keywords:

Gingiva, collagen fiber density, curettage, Spondias pinnata

Abstract

Introduction: Periodontal treatment such as curettage and requires adjuvant therapy for healing process. One of the adjuvant therapies used is hyaluronic acid. Recently, several scientific studies have focused on the antioxidant and anti-inflammatory properties of various natural products such as kecemcem tree bark (Spondias pinnata) having a protective effect against oxidative and inflammatory changes that occur during the development of mucositis. This study aims to determine the effect of 70% Spondias pinnata bark extract gel to increase collagen fiber density after curettage on wistar rats.

Material and Methods: Wistar rats were divided into 3 groups, negative control (CMC-Na gel), positive control (hyaluronic acid gel), and treatment group (70% Spondias pinnata bark extract gel). Mice were sacrificed and then histological preparations were made for further observation in three fields of view using a 400x magnification light microscope.

Results and Discussions:  The average collagen density scoring value was higher than the positive control group and the negative control group. The results of the Mann-Whitney U test showed that there was a significant difference (p<0.05). Flavonoids, phenols, and β-sitosterol in kecemcem bark extract (Spondias pinnata) have an effect on increasing the density of collagen fibers after curettage as indicated by the higher average scoring value in the treatment group.

Conclusion: It can be concluded that 70% 0% Spondias pinnata bark extract gel has the effect of increasing the density of gingival collagen fibers after curettage in Wistar rats (Rattus norvegicus).

Downloads

Download data is not yet available.

References

Newman MG, Takei H, Klokkevold PR, Carranza FA. Newman and Carranza’s Clinical Periodontology. 13th ed. Philadelphia: Elsevier; 2019. h. 19-49.

Michael Glick. Burket’s Oral Medicine. 12th ed. Connecticut: People’s Medical Publishing House; 2015. h. 683.

Peeran SW, Ramalingam K. Essentials of Periodontics & Oral Implantology. 1st ed. India: Saranraj JPS Publication; 2021. h. 11-21.

Shah R, Domah F, Shah N, Domah J. Surgical Wound Healing in the Oral Cavity: a Review. Dental Update 2020; 47(2): 135-143.

Patel S, Maheshwari A, Chandra A. Biomarkers for Wound Healing and Their Evaluation. J Wound Care 2017; 25(1): 46-55.

Cahya RW, Yudaniayanti IS, Wibawati PA, Yunita, MN, Triakoso N, Saputro AL. The Effect of Sukun Leaf (Artocarpus altilis) Extract on Collagen Density of Excision Wound Healing in Albino Rats (Rattus norvegicus). Jurnal Medik Veteriner 2020; 3(1): 25-30.

Wisesa NS. Kombinasi Pasta Ekstrak Daun Jambu Biji (Psidium Guajava Linn.) 5 % Dan Povidon Iodine 10% Efektif Meningkatkan Jumlah Fibroblas dan Ketebalan Kolagen Pasca Pencabutan Gigi Marmut (Cavia Cobaya). Tesis. Denpasar: Pascasarjana Universitas Udayana; 2017. h. 20.

Novitasari AIM, Indraswary R, Pratiwi R. Pengaruh Aplikasi Gel Ekstrak Membran Kulit Telur Bebek 10% terhadap Kepadatan Serabut Kolagen pada Proses Penyembuhan Luka Gingiva. ODONTO Dental Journal 2017; 4(1): 13-20.

Fana SE, Ahmadpour F, Rasouli HR, Tehrani SS, Maniati M. The Effects of Natural Compounds on Wound Healing in Iranian Traditional Medicine: A comprehensive review. Complement Ther Clin Practice 2021; 42(7): 101275-101280.

Murgia MS. New Enzymatic Gel as Adjuvant Treatment for Wound Healing Processes in Oral Surgery, a Mini-Review and a Case Report. Scholars Journal of Medical Case Reports 2017; 9(1): 55-60.

Marathe A, Rao GM, Chakrapani M. Spondias Pinnata Bark Extract-an Ameliorator of Inflammatory Derangement in Etoposide Induced Mucositis: An experimental approach. Veterinary World 2021; 14(7): 1822-1828

Laksemi DAAS. Biological Activity of Spondias Pinnata: A Review. Indonesia Journal of Biomedical Science (IJBS) 2019; 13(2): 88-93.

Balkrishna A. Flora of Morni Hills. India: Divya Yoga Mandir Trust; 2008. h. 1-581.

Bora NS, Bibhuti BK, Barnali G, Ashis KG. Ethno-Medicinal Claims, Phytochemistry and Pharmacology of Spondias Pinnata: A Review. International Journal of Pharmaceutical Sciences and Research (IJPSR) 2014; 5(4): 1138-1145.

Rymbai NA, Deshmukh AK, Jha VK, Verma FG, War D, Paul RS, Patel AR. Breeding of Underutilized Fruit Crops. India: JAYA Publishing House; 2016. h. 183-189.

Suharto, Etika. Ekstrak Jahe (Zingiber Officinale Roscoe) Berpengaruh terhadap Kepadatan Serabut Kolagen Luka Insisi. Jurnal Ilmiah Ilmu Kesehatan 2019; 7(1): 27-36.

Cui S, Hongli J, Lei C, Jian X, Wenzhuo S, Haopeng S, Zijian X, Yunhui X, Fubai Y, Wenyuan L, Feng F, Wei Q. Design, Synthesis and Evaluation of Wound Healing Activity for β-sitosterols Derivatives as Potent Na+/K+-ATPase Inhibitors. Journal Bioorganic Chemistry 2019; 98: 103150-103155.

Sameh, Salma, Eman AS, Rola ML, Abdel NS. Genus Spondias: A Phytochemical and Pharmacological Review. Hindawi Evidence-Based Complementary and Alternative Medicine 2018; 2018(4): 1-13.

Putri RA, Nafi’ah, Sarianoferni. The Differences Between Giving Topical Therapy of Extract etanol 96% and 70% Spirulina Platensis on Density of Collagen Fiber in Traumatic Ulcer Healing. Denta Jurnal Kedokteran Gigi 2019; 13(1): 25-33.

Downloads

Published

2023-12-23

How to Cite

1.
Ramadhany EP, Adibah MS, Dewi AR. EFFECT OF KECEMCEM TREE (SPONDIAS PINNATA) BARK EXTRACT GEL TO INCREASE COLLAGEN POST WISTAR RATS CURETTAGE. interdental [Internet]. 2023 Dec. 23 [cited 2024 Jul. 15];19(2):195-201. Available from: https://e-journal.unmas.ac.id/index.php/interdental/article/view/6686