The Influence of Injectable Platelet Rich Fibrin on Osteogenesis as a Material for Periodontal Regenerative Treatment

Authors

  • Marapandi Cakra Master of Clinical Dentistry Program, Faculty of Dentistry, Gadjah Mada University
  • Kwartarini Murdiastuti Departmen Periodontologi, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta , Indonesia
  • Sri Pramestry Lastianny Departmen Periodontologi, Fakultas Kedokteran Gigi, Universitas Gadjah Mada, Yogyakarta , Indonesia

DOI:

https://doi.org/10.46862/interdental.v20i3.9739

Keywords:

Injectable Platelet Rich Fibrin, osteogenesis, periodontal regenerative treatment

Abstract

Introduction: Periodontal regenerative treatment involves various aspects of achieving healing of soft and hard tissues, thus requiring materials with good regenerative stimulation capabilities. Injectable - Platelet Rich Fibrin or I-PRF is one of the most commonly used materials in regenerative periodontal and has a high success rate in bone regeneration as well as soft tissue in periodontal surgeries. The aim of this review is to provide an overview of the influence of I-PRF on osteogenesis as a material for periodontal regenerative treatment.

Literature Review: I-PRF has a good ability in achieving regeneration of both soft and hard periodontal tissue. The advantages of I-PRF over conventional PRF are higher levels of leukocytes and easier application.

Conclusion: I-PRF is ideal for achieving osteogenesis and periodontal tissue regeneration in regenerative periodontal care.

Downloads

Download data is not yet available.

References

Botirovna SJ, Qizi ZMA, Qizi RSB. Dental periodontitis. Tex J Med Sci 2021; 3(1): 38-39. Doi: https://doi.org/10.62480/tjms.2021.vol3.pp38-39

Kwon T, Lamster IB, Levin L. Current concepts in the management of periodontitis. Int Dent J 2021; 71(6): 1–38. Doi: 10.1111/idj.12630

Preshaw PM, Bissett SM. Periodontitis and diabetes. Br Dent J 2019; 227(7): 577–84. Doi: https://doi.org/10.1038/s41415-019-0794-5

Preshaw PM, Taylor JJ, Jaedicke KM, Jager M, Bikker JW, Selten W, et al. Treatment of periodontitis reduces systemic inflammation in type 2 diabetes. J Clin Periodontol 2020; 47(6): 737–46. Doi: 10.1111/jcpe.13274

Garcia MM, Lemus EH. Periodontal inflammation and systemic diseases: An Overview. Front Physiol 2021; 12(709438): 1-26. Doi: https://doi.org/10.3389/fphys.2021.709438

Fraser D, Caton J, Benoit DSW. Periodontal wound healing and regeneration: insights for engineering new therapeutic approaches. Front Dent Med 2022; 3(815810): 1-24. Doi: https://doi.org/10.3389/fdmed.2022.815810

Sanz M, Herrera D, Kebschull M, Chapple I, Jepsen S, Beglundh T, et al. Treatment of stage I–III periodontitis—The EFP S3 level clinical practice guideline. J Clin Periodontol 2020; 47(S22): 4–60. Doi: 10.1111/jcpe.13290

Iviglia G, Kargozar S, Baino F. Biomaterials, current strategies, and novel nano-technological approaches for periodontal regeneration. J Funct Biomater 2019; 10(1): 3. Doi: https://doi.org/10.3390/jfb10010003

Liang Y, Luan X, Liu X. Recent advances in periodontal regeneration: A biomaterial perspective. Bioact Mater 2020; 5(2): 297–308. Doi: https://doi.org/10.1016/j.bioactmat.2020.02.012

Farmani AR, Nekoofar MH, Ebrahimi Barough S, Azami M, Rezaei N, Najafipour S, et al. Application of platelet rich fibrin in tissue engineering: focus on bone regeneration. Platelets 2021; 32: 183–8. Doi: https://doi.org/10.1080/09537104.2020.1869710

Qilichovna AM. To study the factors that cause periodontitis. J New Century Innov 2024; 49(3): 40–6. Available from: http://www.newjournal.org/

Falcao A, Bullón P. A review of the influence of periodontal treatment in systemic diseases. Periodontol 2000. 2019; 79(1): 117–28. Doi: 10.1111/prd.12249

Yang B, Pang X, Li Z, Chen Z, Wang Y. Immunomodulation in the treatment of periodontitis: progress and perspectives. Front Immunol 2021; 12(1): 781378. Doi: 10.3389/fimmu.2021.781378

Iorio-Siciliano V, Blasi A, Stratul SI, Ramaglia L, Octavia V, Salvi GE, et al. Healing of periodontal suprabony defects following treatment with open flap debridement with or without an enamel matrix derivative: A randomized controlled clinical study. Clin Oral Investig 2021; 25(3): 1019–27. Doi: 10.1007/s00784-020-03392-4

Hai JH, Lee C, Kapila YL, Chaffee BW, Armitage GC. Antibiotic prescribing practices in periodontal surgeries with and without bone grafting. J Periodontol 2020; 91(4): 508–15. Doi: 10.1002/JPER.19-0195

Al-Hamoudi N, Mokeem S, Shafqat SS, Vohra F, Abduljabbar T. Effectiveness of antimicrobial photodynamic therapy as an adjunct to open flap debridement in patients with aggressive periodontitis. Photodiagnosis Photodyn Ther 2021; 33(1): 102075. Doi: 10.1016/j.pdpdt.2020.102075

Pham TAV. Intrabony defect treatment with platelet-rich fibrin, guided tissue regeneration and open-flap debridement: a randomized controlled trial. J Evid Based Dent Pract 2021; 21(3): 101545. Doi: 10.1016/j.jebdp.2021.101545

Pavlovic V, Ciric M, Jovanovic V, Trandafilovic M, Stojanovic P. Platelet-rich fibrin: Basics of biological actions and protocol modifications. Open Med (Pol) 2021; 16(1): 446–54. Doi: 10.1515/med-2021-0259

Deeb MA. Role of Platelet-rich fibrin (PRF) and Platelet-rich plasma (PRP) in oro-facial tissue regeneration: A narrative review. J Adv Oral Res 2020; 11(1): 5–11. Doi: https://doi.org/10.1177/2320206819895836

Caruana A, Savina D, Macedo JP, Soares SC. From Platelet-Rich Plasma to advanced Platelet-Rich Fibrin: biological achievements and clinical advances in modern surgery. Eur J Dent 2019; 13: 280–6. Doi: 10.1055/s-0039-1696585

Kyyak S, Blatt S, Pabst A, Thiem D, Nawas BA, Kämmerer PW. Combination of an allogenic and a xenogenic bone substitute material with injectable platelet-rich fibrin – A comparative in vitro study. J Biomater Appl 2020; 35(1): 83–96. Doi: 10.1177/0885328220914407

Ravi S, Santhanakrishnan M. Mechanical, chemical, structural analysis and comparative release of PDGF-AA from L-PRF, A-PRF and T-PRF - An in vitro study. Biomater Res 2020; 24(1): 16. Doi: 10.1186/s40824-020-00193-4

Arshad S, Tehreem F, Rehab Khan M, Ahmed F, Marya A, Karobari MI. Platelet-rich fibrin used in regenerative endodontics and dentistry: current uses, limitations, and future recommendations for application. Int J Dent 2021;2021(1): 4514598. Doi: 10.1155/2021/4514598

Miron RJ, Moraschini V, Fujioka-Kobayashi M, Zhang Y, Kawase T, Cosgarea R, et al. Use of platelet-rich fibrin for the treatment of periodontal intrabony defects: a systematic review and meta-analysis. Clin Oral Investig 2021; 25(1): 2461–78. Doi: https://doi.org/10.1007/s00784-021-03825-8

Shaikh MS, Zafar MS, Alnazzawi A. Comparing nanohydroxyapatite graft and other bone grafts in the repair of periodontal infrabony lesions: A systematic review and meta-analysis. Int J Mol Sci 2021; 22. Doi: 10.3390/ijms222112021

Grecu AF, Reclaru L, Ardelean LC, Nica O, Ciucă EM, Ciurea ME. Platelet-rich fibrin and its emerging therapeutic benefits for musculoskeletal injury treatment. Medicina (Lithuania) 2019; 55(5): 141. Doi: 10.3390/medicina55050141

Fraser D, Caton J, Benoit DSW. Periodontal Wound Healing and Regeneration: Insights for Engineering New Therapeutic Approaches. Front Dent Med 2022; 3(815810): 1-24. Doi: https://doi.org/10.3389/fdmed.2022.815810

Cho YD, Kim KH, Lee YM, Ku Y, Seol YJ. Periodontal wound healing and tissue regeneration: A narrative review. Pharmaceuticals 2021; 14(5): 456. Doi: 10.3390/ph14050456

Kyyak S, Blatt S, Schiegnitz E, Heimes D, Staedt H, Thiem DGE, et al. Activation of human osteoblasts via different bovine bone substitute materials with and without injectable platelet rich fibrin in vitro. Front Bioeng Biotechnol 2021; 9(599224): 1-11. Doi: https://doi.org/10.3389/fbioe.2021.599224

Giudice A, Antonelli A, Muraca D, Fortunato L. Usefulness of advanced-platelet rich fibrin (A-PRF) and injectable-platelet rich fibrin (I-PRF) in the management of a massive medication-related osteonecrosis of the jaw (MRONJ): A 5-years follow-up case report. Indian J Dent Res 2020; 31(5): 813–8. Doi: 10.4103/ijdr.IJDR_689_19

Fawzy El-Sayed KM, Cosgarea R, Sculean A, Doerfer C. Can vitamins improve periodontal wound healing/regeneration?. Periodontol 2000 2024; 94(1): 539-602. Doi: 10.1111/prd.12513

Farshidfar N, Jafarpour D, Firoozi P, Sahmeddini S, Hamedani S, de Souza RF, et al. The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review of in vitro and in vivo studies. Jpn Dent Sci Rev 2022; 58(1): 89–123. Doi: 10.1016/j.jdsr.2022.02.003

Fujioka-Kobayashi M, Katagiri H, Kono M, Schaller B, Zhang Y, Sculean A, et al. Improved growth factor delivery and cellular activity using concentrated platelet-rich fibrin (C-PRF) when compared with traditional injectable (i-PRF) protocols. Clin Oral Investig 2020; 24(12): 4373–83. Doi: 10.1007/s00784-020-03303-7

Thanasrisuebwong P, Kiattavorncharoen S, Surarit R, Phruksaniyom C, Ruangsawasdi N. Red and yellow injectable platelet-rich fibrin demonstrated differential effects on periodontal ligament stem cell proliferation, migration, and osteogenic differentiation. Int J Mol Sci 2020; 21(14): 1–12. Doi: 10.3390/ijms21145153

Hamid HM, Rady D, Naeem FMA. Comparing the osteogenic and bone regenerative capacities of mta, nano mta, nano hydroxyapatite and injectable platelet rich fibrin in a rat bony defect model. an in vivo study. Egypt Dent J 2020; 66(4): 2773–84. Doi: 10.21608/edj.2020.39462.1210

Boia JRA, Soares LFF, Passos GP, Mariano RC, Junior NVR. Histological and histomorphometrical evaluation of Bio-Oss, Cerabone, and i-PRF for bone regeneration in critical bone defects: An in vivo study. Res Square 2022;1(1): 1–19. Doi: https://doi.org/10.21203/rs.3.rs-1513837/v1

Wang J, Li W, He X, Li S, Pan H, Yin L. Injectable platelet-rich fibrin positively regulates osteogenic differentiation of stem cells from implant hole via the ERK1/2 pathway. Platelets 2023; 34(1): 1-10. Doi: 10.1080/09537104.2022.2159020

Nair UP, Shivamurthy R, Nagate RR, Chaturvedi S, Al-Qahtani SM, Magbol M al, et al. Effect of injectable platelet-rich fibrin with a nano-hydroxyapatite bone graft on the treatment of a grade ii furcation defect. Bioengineering 2022; 9(11): 1-12. Doi: 10.3390/bioengineering9110602

Peeran SW, Ramalingam K, Sethuraman S, Thiruneervannan M. Furcation Involvement in Periodontal Disease: A Narrative Review. Cureus 2024; 16(3): 1-14 Doi: 10.7759/cureus.55924

Jepsen S, Gennai S, Hirschfeld J, Kalemaj Z, Buti J, Graziani F. Regenerative surgical treatment of furcation defects: A systematic review and Bayesian network meta-analysis of randomized clinical trials. J Clin Periodontol 2020; 47: 352–74. Doi: 10.1111/jcpe.13238

Gollapudi M, Bajaj P, Oza RR. Injectable Platelet-Rich Fibrin - A Revolution in Periodontal Regeneration. Cureus 2022; 14(8): 1-5. Doi: 10.7759/cureus.28647

Yuan S, Li Q, Chen K, Mu Z, Chen T, Wang H, et al. Ridge preservation applying a novel hydrogel for early angiogenesis and osteogenesis evaluation: an experimental study in canine. J Biol Eng 2021; 15(19): 1-11. Doi: https://doi.org/10.1186/s13036-021-00271-8

Dufare D. Biomaterials for periodontal regeneration: A brief overview. J Oral Res Rev 2021; 13(1): 70. Doi: 10.4103/jorr.jorr_30_20

Miron RJ, Kobayashi MF, Sculean A, Zhang Y. Optimization of platelet-rich fibrin. Periodontol 2000 2024; 94(1): 79-91. Doi: 10.1111/prd.12521

Ding T, Kang W, Li J, Yu L, Ge S. An in situ tissue engineering scaffold with growth factors combining angiogenesis and osteoimmunomodulatory functions for advanced periodontal bone regeneration. J Nanobiotechnology. 2021;19(1): 247. Doi: 10.1186/s12951-021-00992-4

Zhang J, Yin C, Zhao Q, Zhao Z, Wang J, Miron RJ, et al. Anti-inflammation effects of injectable platelet-rich fibrin via macrophages and dendritic cells. J Biomed Mater Res A 2020; 108(1): 61–8. Doi: 10.1002/jbm.a.36792

Jasmine S, Thangavelu A, Krishnamoorthy R, Alzahrani K, Alshuniaber M. Architectural and ultrastructural variations of human leukocyte-rich platelet-rich fibrin and injectable platelet-rich fibrin. J Microsc Ultrastruct 2021; 9(2): 76–80. Doi: 10.4103/JMAU.JMAU_7_20

Shah R, Thomas R, Gowda TM, Baron TKA, Vemanaradhya GG, Bhagat S. In vitro evaluation of osteoblast response to the effect of injectable platelet-rich fibrin coating on titanium disks. J Contemp Dent Pract. 2021; 22(2): 107–10. Doi: 10.5005/jp-journals-10024-3039.

Galli M, Yao Y, Giannobile WV, Wang HL. Current and future trends in periodontal tissue engineering and bone regeneration. Plast Aesthet Res 2021; 8(3): 1-27. Doi: 10.20517/2347-9264.2020.176

Miron RJ. Optimized bone grafting. Periodontol 2000. 2024; 94(1): 143-160. Doi: https://doi.org/10.1111/prd.12517

Downloads

Published

2024-12-30

How to Cite

1.
Cakra M, Murdiastuti K, Lastianny SP. The Influence of Injectable Platelet Rich Fibrin on Osteogenesis as a Material for Periodontal Regenerative Treatment. interdental [Internet]. 2024 Dec. 30 [cited 2025 Mar. 12];20(3):400-7. Available from: https://e-journal.unmas.ac.id/index.php/interdental/article/view/9739

Issue

Vol. 20 No. 3 (2024): Interdental Jurnal Kedokteran Gigi (IJKG)

Section

Articles

License

Copyright (c) 2024 Marapandi Cakra, Kwartarini Murdiastuti, Sri Pramestry Lastianny

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

  • Every manuscript submitted to must observe the policy and terms set by the Interdental Jurnal Kedokteran Gigi (IJKG)
  • Publication rights to manuscript content published by the Interdental Jurnal Kedokteran Gigi (IJKG) is owned by the journal with the consent and approval of the author(s) concerned.
  • Full texts of electronically published manuscripts can be accessed free of charge and used according to the license shown below.