The Corticosteroids Intralesional Injections as a Treatment of Oral Lichen Planus: Systematic Literature Review
DOI:
https://doi.org/10.46862/interdental.v20i3.9649Keywords:
Corticosteroids,, intralessional injections, oral lichen planusAbstract
Introduction. Oral Lichen Planus (OLP) is a chronic immunological disorder that is inflammatory in form. Unlike skin lesions, oral lesions are more resistant to local and systemic therapy. The aim of this literature review is to explain alternative therapies in OLP cases using intralesional injection techniques.
Literature Review. In general, OLP lesions in the oral cavity have no symptoms, but the atrophic-erosive form has mild symptoms such as discomfort and soreness. OLP therapy can generally be carried out with systemic or local therapy, however, OLP therapy is a long-term therapy that can be a challenge of the treatment, particularly in complex medical patients.
Discussion. The use of corticosteroids in oral diseases is generally as anti-inflammatory, anti-proliferative, and immunosuppressive. Various methods, such as topical and systemic corticosteroids, griseofulvin, topical retinoids, hyaluronic acid, tetracycline, and topical cyclosporine, have been used to reduce morbidity. From several previous studies, Triamcinolone acetonide injection is a corticosteroid commonly used in OLP therapy in varying doses. In general, Triamcinolone acetonide injection is given in a dose of 20mg/ml or 40mg/ml.
Conclusion. Injectable corticosteroids, especially Triamcinolone acetonide, are an effective therapy as an OLP treatment that can minimize the side effects of long-term corticosteroid therapy.
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Sethi U, Puri N, More CB, Gupta R, Gupta D. Comparative evaluation of effectiveness of autologous platelet rich plasma and intralesional corticosteroids in the management of erosive oral Lichen planus- a clinical study. J Oral Biol Craniofacial Res. 2020;10(4):714-718. Doi:10.1016/j.jobcr.2020.09.008
El-Marssafy LH, Sadek HS, Hussein FF, Alqahtani M, Abdelghany WM. Clinical Evaluation of Using Benzydamine Hydrochloride Oral Gel With Intralesional Injection for Pain Control in Symptoatic Oral Lichen Planus. Egypt Dent J. 2020;66(2):969-979. Doi: 10.21608/edj.2020.25533.1067
García-pola MJ, González-álvarez L, Garcia-martin JM. Treatment of oral lichen planus. Systematic review and therapeutic guide. Med Clínica (English Ed.) 2017;149(8):351-362. Doi:10.1016/j.medcle.2017.09.013
Lee YC, Seok J, Ah L, Jung R, Min J, Eun PY gyu. Factors Affecting the Result of Intralesional Corticosteroid Injection in Patients With Oral Lichen Planus. Clin Exp Otorhinolaryngol. 2018;11(3):205-209. Doi: 10.21053/ceo.2017.01319.
Hijazi AH, Ahmed W, Gaafar S. Efficacy of intralesional injections of platelet‐rich plasma in patients with Oral Lichen Planus: A Pilot Rondomized Clinical Trial. Clin Exp Dent Res. 2022;8:707-714. Doi: Hijazi AH, Ahmed W, Gaafar S. Efficacy of intralesional injections of platelet‐rich plasma in patients with Oral Lichen Planus: A Pilot Rondomized Clinical Trial. Clin Exp Dent Res. 2022;8:707-714.
Kurt MH, Kolsuz ME, Eren H. Corticosteroid injection in treatment of persistent oral lichen planus: Three cases. Dermatologic Therapy. 2019; 32:e13015. Doi:10.1111/dth.13015.
Alsubhi A, Salem N, Mohab M, et al. Intralesional Corticosteroid Injections for the Treatment of Oral Lichen Planus : A Systematic Review. J Dermatology Dermatologic Surg. 2020;24(2):74-80. Doi:10.4103/jdds.jdds
Gujjar P, Zingade J, Patil S, Hallur J. Recent Update on Treatment Modalities of Oral Lichen Planus – A Review. IJSS Case Reports Reveiews. 2015;2(4):40-44. Doi:10.17354/cr/2015/138
Agha-Hosseini F, Atyabi F, Akbari K, Moosavi M. Decreased recurrence of symptoms in oral lichen planus with intralesional injection of hyaluronic acid and triamcinolone. Int J Oral Maxillofac Surg. 2019. Doi:10.1016/j.ijom.2021.02.028
Zhao W, Lin D, Deng S, et al. Synergistic Efficacy of Plaque Control with Intralesional Triamcinolone Acetonide Injection on Erosive Non-Gingival Oral Lichen Planus : A Randomized Controlled Clinical Trial. Int J Environ Res Public Health. Doi: 10.3390/ijerph192113787.
Ibrahim M, Soheir E, Asmaa G, Ms E. Intralesional injection of platelet- rich plasma versus steroid in the treatment of oral lichen planus. J Cosmet Dermatol. 2023(5):1481-1487. Doi:10.1111/jocd.15622
Walia C, Rallan NS, Premkumar A, Roy S. Clinical Evaluation of Efficacy of Triamcinolone Acetonide with Tacrolimus in the Management of Oral Lichen Planus : A Pilot Prospective Observational Study. Contemp Clin Dent. 2022;13(3):236-241. Doi:10.4103/ccd.ccd
Ion DI, Setterfield JF. Oral Lichen Planus. Prim Dent J. 2016;5(1):40-44. Doi: 10.1177/205016841600500104.
Yang H, Wu Y, Ma H, et al. Possible alternative therapies for oral lichen planus cases refractory to steroid therapies. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 121(5):496-509. Doi:10.1016/j.oooo.2016.02.002.
Youssef MI, Sayed NM El, Darwis ZE, Fahmy RA. The Effect of Topically Applied Hyalurinic Acid Gel Versus Topical Corticosteroids in the Treatment of Erosive Oral Lichen Planus. Alexandria Dental Journal 2019;44(4):57-63. Doi: 10.21608/adjalexu.2019.57577.
Sari NNG, Dewi IK. Perbandingan Efektivitas Ekstrak Daun Binahong (Anredera Cordifolia (Ten.) Steenis) 25% Dan 50% Dibandingkan Obat Triamcinolone Acetonide Terhadap Penyembuhan Recurrent Aphthous Stomatitis (Ras) Minor. Interdental J Kedokt Gigi. 2020;16(2):44-48. Doi:10.46862/interdental.v16i2.1125
Wibowo A, Soenarjo S, Satoto HH. Perbandingan Penggunaan Triamcinolone Acetonide Dan Gel Larut Air Pada Pipa Endotrakea Terhadap Angka Kejadian Nyeri Tenggorok. JAI (Jurnal Anestesiol Indonesia) 2014;6(3):170-181. Doi:10.14710/jai.v6i3.9122
Garg AM, Shah YM, Garg A, et al. The efficacy of intralesional triamcinolone acetonide (20mg/ml) in the treatment of keloid. Int Surg J. 2018;5(3):868. Doi:10.18203/2349-2902.isj20180497
Sandhu S, Klein BA, Hadlaq M Al, et al. Oral lichen planus : comparative efficacy and treatment costs — a systematic review. BMC Oral Health 2022; 22(1):161. Doi:10.1186/s12903-022-02168-4
Gupta S, Ghosh S, Gupta S. Interventions for the management of Oral Lichen Planus: A Review of the Conventional and Novel Therapies. Oral Dis 2017; 23(8): 1029-1042. Doi:10.1111/ijlh.12426
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