Factors Associated with Oral Discomfort at The Menopausal Stage: A Systematic Review
DOI:
https://doi.org/10.46862/interdental.v22i2.14274Keywords:
menopause, climacteric, oral discomfort, oral manifestationsAbstract
Introduction: Menopause is a physiological process that all women experience and is often regarded as a sign of aging in women. The signs and symptoms of menopause are very diverse, and oral discomfort is one of the symptoms. Oral discomfort can interfere with oral cavity function, indirectly affecting nutrient intake. This study aims to evaluate factors associated with oral discomfort and oral manifestations of the menopausal stage.
Review: This review is based on the PRISMA statement. A literature review incorporated observational studies from the last five years and across 5 databases. An investigative question was formulated using the PEOS model, studies were selected, and a quality analysis was performed in accordance with the STROBE guidelines. The bibliometric analysis was performed, and the data were qualitatively analyzed. A total of 19 articles met the inclusion criteria, with the majority of oral manifestations at the menopausal stage being xerostomia, burning sensation, taste disturbances, and periodontitis. Duration of menopause, bad oral hygiene, lower salivary flow rate, higher calcium saliva concentration, and salivary estrogen level were found to be associated factors for oral discomfort at the menopausal stage.
Conclusions: The menopausal stage may increase the risk of oral discomfort due to decreased estrogen levels in saliva. Since the estrogen receptor was found in the oral cavity, especially in the mucosa, salivary gland, and periodontium, it can directly affect the oral cavity.
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1. Agrawal J, Rehan AD, Shilpi, Ravi R. Oral health of women during menopause and its management- a literature review. J Popul Ther Clin Pharmacol. 2024;31(1):2044-2049. DOI:10.2139/ssrn.4919734
2. Kirchengast S. Menopause in a globalized world – A systematic literature review focusing on the challenge of health problems associated with menopausal transition among women with a migration background. Maturitas. 2024;187(Supply.2):1-7. DOI:10.1016/j.maturitas.2024.108045
3. Thapa R, Yang Y. Menopausal symptoms and related factors among Cambodian women. Women Heal. 2020;60(4):396-411. DOI:10.1080/03630242.2019.1643815.
4. Marvi N, Mollazadeh S, Erfanian Arghavanian F, Atashi A, Khadivzadeh T. Designing, validation and evaluation of the expert system of “Healthy Menopause” and assessing its effect on the management of menopause symptoms: an exploratory mixed method study protocol. Reprod Health. 2024;21(1):1-6. DOI:10.1186/s12978-024-01740-1
5. Kranjčević JK, Čonkaš J, Ozretić P. The role of estrogen and estrogen receptors in head and neck tumors. Cancer. 2024;16(1575):1-33. DOI:10.3390/cancers16081575.
6. Ashraf M, Kamp E, Musbahi E, DeGiovanni C. Menopause, skin and common dermatoses. Part 4: oral disorders. Clin Exp Dermatol. 2022;47(12):2130-2135. DOI:10.1111/ced.15341
7. Popa C, Neamțu M, Andreea Onofrei B, Paula Toader M, Mihaela Condurache Hritcu O, Maria Sciuca A. Oral pathology in the context of menopause in women. Rom J Oral Rehabil. 2024;16(1): 461-467. DOI:10.62610/RJOR.2024.1.16.44
8. Farah CS, Balasubramaniam R, McCullough MJ. Contemporary oral medicine: A comprehensive approach to clinical practice. Springer; 2019. DOI:10.1007/978-3-319-72303-7
9. Ozasa K, Noma N, Young A, Korczeniewska OA, Eliav E, Imamura Y. Potential differences in somatosensory function during premenopause and early and late postmenopause in patients with burning mouth syndrome: An observational case–control study. J Dent Sci. 2022;17(1):399-406. DOI:10.1016/j.jds.2021.08.010.
10. Harika PD, Garlapati K, Badam RK, Gone P, Aiman A, Rajani H, et al. Taste changes and salivary flow rate disparities in premenopausal and postmenopausal women: exploring the zinc connection. Cureus. 2024;16(6):1-16. DOI:10.7759/cureus.62538.
11. Cydejko A, Kusiak A, Grzybowska ME, Kochańska B, Ochocińska J, Maj A, et al. Selected physicochemical properties of saliva in menopausal women-a pilot study. Int J Environ Res Public Health. 2020;17(7):1-9. DOI:10.3390/ijerph17072604.
12. Cuschieri S. The STROBE guidelines. Saudi J Anaesth. 2019;13(Suppl 1):S31-S34. DOI:10.4103/sja.SJA_543_18
13. Sumit K, Vikram K, Rajlaxmi M, Ranjitkumar P, Anastasios G, Abhishek K. Evaluation of oral health, taste perception, nutritional status and emotional well-being in post-menopausal women. J Oral Rehabil. 2024;51(9):1833-1838. DOI:10.1111/joor.13734
14. Muneshwar SS, Ashwinirani SR, Gole AA, Suragimath G. Oral manifestation in postmenopausal women of Maharashtra, Western Region. J Midlife Health. 2023;14(1):28-33. DOI:10.4103/jmh.jmh_194_22.
15. Poudel K, Poudel R, Nair GKR, Gaur A, Mohan V, Sharma KG. Evaluation of unstimulated salivary flow rate and oral symptoms in postmenopausal women ‑ A clinical study in healthy subjects. Journal of Indian Academy of Oral Medicine and Radiology. 2023;35(2):202-2066. DOI:10.4103/jiaomr.jiaomr.
16. Gupta A, Pallagatti S, Gupta D, Aggarwal A, Singh R. Unstimulated salivary estrogen in postmenopausal women with and without oral dryness: A prospective study. Open Dent J. 2022;16(1):1-8. DOI:10.2174/18742106-v16-e2202140
17. Ruchi G, Madhu R, Pratik C, Shaleen K, Prince S, Rishi T. Evaluation and comparison of oral & periodontal health status in post-menopausal females with and without xerostomia. Int J Health Sci (Qassim). 2022;6(S2):8241-8249. DOI:10.53730/ijhs.v6ns2.7095.
18. Yasuda M, Ito K, Nohno K, et al. Association between multiple oral complaints and menopausal symptoms: an observational study. J Women’s Heal Dev. 2022;05(01):1-14. DOI:10.26502/fjwhd.2644-28840072.
19. Soundarya B, Massillamani F, Kailasam S, Jayashree G, Narmadha N, Sornaa N. Salivary menopausal markers and oral health status-A hidden hook-up. J Midlife Health. 2022;13(2):157-162. DOI:10.4103/jmh.jmh-61-21.
20. Li Y, Zhao D, Wang M, Sun JY, Liu J, Qi Y, et al. Association of menopause with risk of carotid artery atherosclerosis. Maturitas. 2021;143:171-177. DOI:10.1016/j.maturitas.2020.10.007.
21. Kim JI, Choi CH, Chung KH. No association between metabolic syndrome and periodontitis in Korean postmenopausal women. Int J Environ Res Public Health. 2021;18(21):11110. DOI:10.3390/ijerph182111110
22. Agrawal AT, Hande A, Reche A, Paul P. Appraisal of saliva and its sensory perception in reproductive transitions of women: a review. Cureus. 2022;14(11). DOI:10.7759/cureus.31614.
23. Yakar N, Türedi A, Emingil G, Şahin Ç, Köse T, Silbereisen A, et al. Oral health and emotional well-being in premenopausal and postmenopausal women: A cross-sectional cohort study. BMC Womens Health. 2021;21(1):338. DOI:10.1186/s12905-021-01480-5
24. Lee Y. Association between osteoporosis and periodontal disease among menopausal women: The 2013-2015 Korea National Health and Nutrition Examination Survey. PLoS One. 2022;17(3):e0265631. DOI:10.1371/journal.pone.0265631.
25. Rafiei M, Salarisedigh S, Khalili P, Jamali Z, Sardari F. Hormonal fluctuations and periodontal status in postmenopausal women. Int J Dent. 2022;2022:9990451. DOI:10.1155/2022/9990451.
26. Poudel K, Poudel R, Nair GKR, Gaur A, Mohan V, Sharma KG. Evaluation of unstimulated salivary flow rate and oral symptoms in postmenopausal women-a clinical study in healthy subjects. J Indian Acad Oral Med Radiol. 2023;35(2):202-206. DOI:10.4103/jiaomr.jiaomr_75_23
27. Ekhtiari A. Comparison of Taste Threshold In Postmenopausal and Non-Menopausal Women and Men. Research Square [Internet]; 2024. p.1-19. DOI:10.21203/rs.3.rs-4926228/v1.
28. Wang L, Zhu L, Yao Y, Ren Y, Zhang H. Role of hormone replacement therapy in relieving oral dryness symptoms in postmenopausal women: a case-control study. BMC Oral Health. 2021;21(1):1-7. DOI:10.1186/s12903-021-01966-6.
29. Kim JI, Choi CH, Chung KH. Association between metabolic syndrome and the number of remaining teeth in postmenopausal women: A cross-sectional analysis using the Korean National Health and Nutritional Examination Survey. J Clin Med. 2021;10(20). DOI:10.3390/jcm10204759.
30. Zovari F, Parsian H, Bijani A, Moslemnezhad A, Shirzad A. Evaluation of salivary and serum total antioxidant capacity and lipid peroxidation in postmenopausal women. Int J Dent. 2020;2020:8860467. DOI:10.1155/2020/8860467.
31. Richa Agrawal, Hina Ahmed, Neeharika Soorgani, Laxman Naik, Shyamsunder Reddy MM. Assessment of periodontal status in pre‑ and postmenopausal women with chronic periodontitis: a cross‑sectional study. J Pharm Bioallied Sci. 2021;13(Supply 2):S997-9. DOI:10.4103/jpbs.jpbs_145_21.
32. Bogdan-Andreescu CF, Bănățeanu AM, Albu CC, et al. Oral mycobiome alterations in postmenopausal women: links to inflammation, xerostomia, and systemic health. Biomedicines. 2024;12(11):2569. DOI:10.3390/biomedicines12112569.
33. Sen S, Sen S, Dutta A, Abhinandan, Kumar V, Singh AK. Oral manifestation and its management in postmenopausal women: An integrated review. Prz Menopauzalny. 2020;19(2):101-103. DOI:10.5114/pm.2020.97867
34. Larasati A, Kusdhany LS, Soejono CH, Indrasari M. Links between oral function and cognitive function in older adults. Interdental J Kedokt Gigi. 2025;21(3):484-494. DOI:10.46862/interdental.v21i3.12476.
35. Shrivastava S. Menopause and oral health: Clinical implications and preventive strategies. J Midlife Health. 2024;15(3):135-141. DOI:10.4103/jmh.jmh_125_24.
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