Literature Review: The Potential of Soursop Leaves (Annona muricata L.) as a Cholesterol-Lowering Medicine
DOI:
https://doi.org/10.36733/usadha.v3i2.9140Keywords:
soursop leaves, self-medication, cholesterolAbstract
Cholesterol is a fat or lipid from the sterol group produced by the body. The higher the cholesterol level in the blood, the greater the risk of atherosclerosis, which is the first step in triggering other cardiovascular diseases such as hypertension, coronary heart disease, and even stroke and death. One of the synthetic drugs commonly used to treat high cholesterol is statins, especially atorvastatin. However, long-term use of atorvastatin can cause several side effects, including muscle pain, liver damage, type 2 diabetes, and digestive disorders. Because of the risk of these side effects, many people turn to herbal-based alternative treatments which are considered safer. Self-medication can be done to reduce high cholesterol levels. Self-medication is a community effort to obtain and use traditional medicine independently. One of the traditional medicines that is believed to lower cholesterol levels is soursop leaves. This research aims to look at the potential of soursop leaves as a medicine to lower cholesterol levels and provide a choice for people who want to reduce their cholesterol levels, especially for sufferers of hypercholesterolemia. This article is a literature review article using the literature review study method. A literature search was carried out using the Google Scholar database, namely articles or guidelines on the potential of soursop leaves as a medicine to lower cholesterol levels published in the last 10 years. The research results show that soursop leaves have a significant effect on reducing cholesterol levels. So soursop leaves can be considered a safe and effective herbal treatment for hypercholesterolemia.
References
Al Amin, M. Efektivitas Ekstrak Daun Annona Muricata Terhadap Penurunan Kolesterol Total Pada Lansia Dengan Hiperkolesterolemia Di Panti Werdha Mojopahit Mojokerto. PROFESSIONAL HEALTH JOURNAL. 2023; 5(1), 80-89.
Al-Rahmad, A. H., Annaria, A., & Fadjri, T.K. Faktor Resiko Peningkatan Kolesterol pada Usia Diatas 30 Tahun di Kota Banda Aceh. Jurnal Nutrisia. 2016; 18(2), 109–114.
Aisah, S., Danismaya, I., & Suryadi, B. Pengaruh Terapi Rebusan Daun Sirsak Terhadap Penurunan Kadar Kolesterol pada Penderita Hiperkolesterolemia di Wilayah KP Tipar Tahun 2022. 2023; 2(1).
Anies. Kolesterol dan penyakit jantung koroner. Surabaya:Ar-ruzz media; 2015
Dharma, S., Supanda, O., & Elisma, E. Pengaruh Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Terhadap Kadar LDL Pada Mencit Putih Jantan. Jurnal Farmasi Higea. 2017; 6(1), 68-77.
Eliyanti, U., & Hanif, I. Hypertension and Cholesterol among Late Adults in Indonesia : A CrossSectional Population-Based Survey. Journal of Health Economic and Policy Research. 2023; 1.
Firmansyah, D., Bachri, M., & Nurkhasanah, N. Pengaruh pemberian ekstrak etanol dan kloroform daun sirsak terhadap kolesterol total dan trigliserida pada tikus yang diinduksi aloksan. Pharmaciana.2016; 6(1), 47-54.
Gusnelti, Y., & Nurjanah, E. Pengaruh Pemberian Ekstrak Etanol Daun Sirsak (Annona muricata L.) Terhadap Kadar Kolesterol Total Pada Mencit (Mus musculus). Jurnal Medisains Kesehatan. 2022; 3(1), 6-13.
Iskandar, R. I., Handayani, N., & Sri, T. Pengaruh Infusa Daun Sirsak(Annona muricata L.) Terhadap penurunan kadar kolesterol mencit jantan(Mus musculus) Galur Swiss Webster.Media Informasi. 2017; 13(1), 102–107.
Rahmayanti, U. R., Ayu, I. G., Danuyanti, N., & Zaetun, S. Pemanfaatan Teh Daun Sirsak ( Annona muricata L .) Terhadap Kadar Kolesterol Total , Trigliserida Dan Glukosa Darah Pada Pasien Diabetes Mellitus Dengan Hipertensi insulin atau kombinasi keduanya.2022; 8(2), 119–133
Redaksi Trubus. Daun Sirsak Vs Kanker. PT Trubus Swadaya: Depok; 2022
Fatimah, S., Arisandi, D., & Sismawati, S. Pengaruh Pemberian Ekstrak Etanol Buah Sirsak (Annona muricata L.) Pada Kadar Kolesterol Low Density Lipoprotein (LDL) Tikus Putih (Rattus norvegicus) Hiperkolesterolemia. Biomedika. 2019; 12(2), 167-174.
Setiawati, S., Anggraini, F., & Sundari, F. REBUSAN DAUN SISRAK EFEKTIF DALAM MENURUNKAN KADAR KOLESTEROL PADA WANITA LANSIA. Jurnal Ilmu Keperawatan dan Kebidanan. 2024; 15(1), 119-127.
Uneputty, J. P., Yamlean, P. V., & Kojong, N. Potensi infusa daun sirsak (annona muricata l.) terhadap kadar kolesterol darah tikus putih jantan (rattus novergicus). Pharmacon. 2016; 2(2).
Wulandari, R. L., Susilowati, S., & Asih, M. Pengaruh Kombinasi Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Dan Simvastatin Terhadap Kadar Kolesterol Total Dan Low Density Lipoprotein (LDL) Tikus Yang Diinduksi Pakan Tinggi Lemak. Jurnal Ilmu Farmasi dan Farmasi Klinik. 2015; 12(2), 24-32.
Yuniarti, L., Dewi, M. K., Lantika, U. A., & Bhatara, T. Potensi ekstrak air daun sirsak sebagai penurun kolesterol dan pengendali bobot badan. Acta Veterinaria Indonesiana. 2016; 4(2), 82-87.
