Obat Herbal Berbasis Bukti Untuk Hepaprotektor: Obat Herbal Berbasis Bukti Untuk Hepaprotektor

Ni Putu Dewi Agustini; Ni Luh Kade Arman Anita Dewi; Fitria Megawati; Ratna Wulandari

doi:10.36733/usadha.v2i1.5925

Authors

Ni Putu Dewi Agustini a:1:{s:5:"id_ID";s:34:"Universitas Mahasaraswati Denpasar";}
Ni Luh Kade Arman Anita Dewi Fakultas Farmasi Universitas Mahasaraswati Denpasar
Fitria Megawati Fakultas Farmasi Universitas Mahasaraswati Denpasar
Ratna Wulandari Fakultas Farmasi Universitas Mahasaraswati Denpasar

DOI:

https://doi.org/10.36733/usadha.v2i1.5925

Keywords:

Hepaprotecthepatoprotektor, Herbal Medicine, NAPQI

Abstract

Liver damage can occur due to infection, viruses, drug use, and the environment. Paracetamol is a drug that has analgesic and antipyretic effects, but on the other hand the use of paracetamol in excessive doses (15/day) can cause liver damage. This can occur because the process of paracetamol metabolism in the liver forms a reactive metabolite known as N-acetyl-pbenzoquinonemine (NAPQI). The hepatoprotective mechanism can be seen from the ability of Ichnocarpus frutescens to ward off free radicals formed from the process of lipid oxidation due to the reactive metabolite of paracetamol, namely NAPQI. The method used is a literature review which is a systematic, explicit and reproducible method for carrying out identification, evaluation and synthesis of research works and ideas that have been produced by researchers and practitioners. The data base used is National and International Journal Websites such as Google Scholar.

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Obat Herbal Berbasis Bukti Untuk Hepaprotektor