Formulation and Physical Quality Evaluation of Hylocereus lemairei Rind Extract Lip Balm with Cera Alba Concentration Variations

Authors

  • Ni Made Dharma Shantini Suena Universitas Mahasaraswati Denpasar
  • Ni Putu Ocha Indira Intansari Universitas Mahasaraswati Denpasar
  • I Gede Made Suradnyana Universitas Mahasaraswati Denpasar
  • Ni Nyoman Yudianti Mendra Universitas Mahasaraswati Denpasar
  • Ni Putu Udayana Antari Universitas Mahasaraswati Denpasar

DOI:

https://doi.org/10.36733/usadha.v2i1.5583

Keywords:

Red dragon fruit peel extract, Physical quality

Abstract

Red dragon fruit skin (Hylocereus lemairei) contains flavonoid compounds (polyphenols), and vitamins C and E which play the main role as antioxidants, so they are good for moisturizing, nourishing, and maintaining skin health. Lip balm is a cosmetic preparation with main components such as waxes, fats, and oils from natural or synthesized extracts to prevent dryness by increasing lip moisture. The stability of preparation is very important in maintaining the physical quality of the preparation until it reaches the consumer. This study aims to determine the concentration of Cera alba as a stiffening agent needed to produce lip balm preparations of red dragon fruit skin extract (Hylocereus lemairei) with good physical quality. The response observed was the physical quality of the lip balm preparation which included organoleptic, homogeneity, pH, adhesion, and mechanical strength of the lip balm. Data analysis was carried out descriptively. This research begins with the extraction process of red dragon fruit skin using an ultrasonic wave-assisted maceration method using 96% ethanol and 1% HCl. In this study, a lip balm formulation was made from red dragon fruit peel extract with various concentrations of Cera alba 5% (F1), 10% (F2), and 15% (F3) as a stiffening agent. The resulting preparations were stored for 28 days, and their physical quality was observed. The results showed that lip balm preparations F3 produced good physical quality of lip balm preparations during storage. Dragon fruit peel extract can be properly formulated using Cera alba at a concentration of 15% to become a lip balm preparation that has high-quality physical characteristics and has the potential to be developed into a cosmetic preparation that is able to maintain skin moisture, especially the lips.

 

Author Biographies

Ni Made Dharma Shantini Suena, Universitas Mahasaraswati Denpasar

Department of Pharmaceutics, Pharmacy Bachelor Program, Faculty of Pharmacy

Ni Putu Ocha Indira Intansari, Universitas Mahasaraswati Denpasar

Pharmacy Diploma Three Program

I Gede Made Suradnyana, Universitas Mahasaraswati Denpasar

Departement of Pharmaceutics

Ni Nyoman Yudianti Mendra, Universitas Mahasaraswati Denpasar

Departement of Pharmaceutics

Ni Putu Udayana Antari, Universitas Mahasaraswati Denpasar

Departement of Social Pharmacy

References

. Gunt H, Levy SB. Efficacy of a nature-based lip treatment to repair dry damaged lips: Clinical and biophysical assessments. J Am Acad Dermatol. 2020;83(6):AB168. https://doi.org/10.1016/j.jaad.2020.06.762

. Ambari Y, Hapsari FND, Ningsih AW, Nurrosyidah IH, Sinaga B. Studi Formulasi Sediaan Lip Balm Ekstrak Kayu Secang (Caesalpinia sappan L.) dengan Variasi Beeswax. J Islam Pharm. 2020;5(2):36–45. https://doi.org/10.18860/jip.v5i2.10434

. Winahyu DA, Purnama RC, Setiawati MY. Test of Antioxidant Activities in Red Dragon Fruit Extract (Hylocereus polyrhizus) Using DPPH Method. J Anal Farm. 2019;4(2):117–21.

. Sawiji RT, Utariyani NW. Optimasi Komposisi PVA Dan Gliserin Pada Masker Gel Peel Off Ekstrak Kulit Buah Naga ( Hylocereus lemairei ) Secara Simplex Lattice Design Optimization of PVA and Glycerin Composition in Peel Off Gel Mask Dragon Fruit Skin Extract ( Hylocereus lemairei ). JIM J Ilm Mahaganesha. 2022;1(1):18–26. Available from: https://ojs.farmasimahaganesha.ac.id/index.php/JIM/article/view/58

. Wahdaningsih S, Budilaksono W, Fahrurroji A. Uji aktivitas antioksidan fraksi n-heksana kulit buah naga merah menggunakan metode 1,1-Difenil-2-Pikrilhidrazil. J Kesehat Khatulistiwa. 2015;1(2):115. https://doi.org/10.26418/jurkeswa.v1i2.42997

. Utami W, Mardawati E, Putri SH. Pengujian Aktivitas Antioksidan Kulit Buah Naga Merah (Hylocereus polyrhizus) Sebagai Masker Gel Peel Off. J Ind Pertan. 2020;2(1):95–102. Available from: http://jurnal.unpad.ac.id/justin/article/view/26181

. Ali Jaafar R, Abdul Rahm AR Bin, Che Mahmod NZ, Vasudevan R. Proximate Analysis of Dragon Fruit (Hylecereus polyhizus). Am J Appl Sci. 2009;6(7):1341–6. https://doi.org/10.3844/ajassp.2009.1341.1346

. Yahya H. Analisis Kandungan Vitamin C pada Buah Naga yang Diperjualbelikan di Sekitar Kota Makasar. Media Laboran J Anal Kesehat. 2017;7(1):20–3. Available from: https://uit.e-journal.id/MedLAb/article/view/350

. Adhayanti I, Ahmad T. Kadar Vitamin C dan Aktivitas Antioksidan Kulit Buah Naga Segar (Hylocereus S). Media Farm. 2021;17(2):157. https://doi.org/10.32382/mf.v17i2.2273

. Kembuan MV, Wangko S, Tanudjaja GN. Peran Vitamin C terhadap Pigmentasi Kulit. J BIOMEDIK. 2013;4(3). https://doi.org/10.35790/jbm.4.3.2012.1215

. Devitasari R, Basuki S. Peran Vitamin E pada Kulit. J Klin dan Ris Kesehat. 2022;1(2):116–26. https://doi.org/10.11594/jk-risk.01.2.6

. Aryanta IWR. Manfaat Buah Naga Untuk Kesehatan. Widya Kesehat. 2022;4(2):8–13. https://doi.org/10.32795/widyakesehatan.v4i2.3386

. Hernawati, Setiawan NA, Shintawati R, Priyandoko D. The role of red dragon fruit peel (Hylocereus polyrhizus) to improvement blood lipid levels of hyperlipidaemia male mice. J Phys Conf Ser. 2018;1013(1):012167. https://doi.org/10.1088/1742-6596/1013/1/012167

. Putridhika SQ, Ratnasari D, Gatera VA. Uji Aktivitas Antioksidan dari Sediaan Lip Balm Kulit Buah Naga Merah (Hylocereus polyrhizus). J Pendidik dan Konseling. 2022;4(5):5845–51.

. Sheskey PJ, Cook WG, Cable CG, editors. Handbook of Pharmaceutical Excipients. 8th ed. London; Washington DC.: Pharmaceutical Press and American Pharmacist Association; 2017. 1216 p.

. Anjari W. Pengaruh Cera Alba sebagai Wax terhadap Sifat Fisik Lip Gloss Ekstrak Etanol Biji Kesuma Keling (Bixa orellana L.). Program Studi Farmasi, Fakultas Kedokteran. Universitas Tanjungpura Pontianak; 2018.

. Abdul Wahid Suleman, Sri Wahyuningsih, Safaruddin, Rizky Indah Pratiwi. Formulasi dan Evaluasi Stabilitas Sediaan Lip Balm Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) dengan Penambahan Minyak Zaitun sebagai Emolien serta Penentuan Nilai SPF (Sun Protection Factor). Med Sains J Ilm Kefarmasian. 2022;7(4):899–906. https://doi.org/10.37874/ms.v7i4.428

. Sari NKK, Suradnyana IGM, Suena NMDS. Uji Stabilitas Fisik Body Butter Maserat Air Biji Kopi Hijau (Coffea canephora) pada Suhu Sejuk. J Farm Higea. 2021;13(2):79–91. Available from: https://www.jurnalfarmasihigea.org/index.php/higea/article/view/363

. Anisa H, Sukmawardani Y, Windayani N. A simple formulation of lip balm using carrot extract as a natural coloring agent. J Phys Conf Ser. 2019;1402(5):055070. https://doi.org/10.1088/1742-6596/1402/5/055070

. Ningrum YDA, Azzahra NH. Formulasi Sediaan Lip Balm Minyak Zaitun Halal dan Uji Kestabilan Fisik. Indones J Pharm Nat Prod. 2022;05(2):137–41. https://doi.org/10.35473/ijpnp.v5i2.1652

. Bornare A, Tribhuwan T, Magare S, Shinde A, Tarkase S. Formulation and Evaluation of Herbal Lipstick. Int J Creat Res Thoughts. 2020;8(9):2390–400. https://doi.org/10.4103/0250-474X.93515

. Dusane AV, Tiwari MN, Patade PP. Novel Herbal lipstick formalations and their Quality control. Int J Sci Res Publ. 2020;10(3):p9953. https://doi.org/10.29322/IJSRP.10.03.2020.p9953

. Martin AN, Sinko PJ. Martin’s Phycical Pharmacy and Pharmaceutical Sciences: physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Sixth. Sinko PJ, Singh Y, editors. Philadelphia: Lippincott Williams & Wilkins, a Wolters Kluwer business; 2011. 1–594 p.

. Allen LVJ, Ansel HC. Ansel’s Pharmaceutical DOsage Forms and Drug Delivery System. 10th ed. Howes S, editor. Vol. 148. Philadelphia: Lippincott Williams & Wilkins, a Wolters Kluwer business; 2014. 809 p.

. Karimah N, Ratih Aryani, Sani Ega Priani. Studi Literatur Aktivitas Antibakteri Penyebab Jerawat dari Minyak Atsiri dan Formulasinya dalam Sediaan Mikroemulsi. J Ris Farm. 2021;1(1):46–54. https://doi.org/10.29313/jrf.v1i1.185

. Suena NMDS, Ariani NLWM, Antari NPU. Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory. J Ilm Medicam. 2022;8(1):22–30. https://doi.org/10.36733/medicamento.v8i1.3425

Published

2022-12-31

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Section

Articles