FIXED DOSE COMBINATION OF MECOBALAMIN AND PREGABALIN IN THE TREATMENT OF OROFACIAL NEUROPATHIC PAIN
DOI:
https://doi.org/10.46862/interdental.v20i1.8570Keywords:
Mecobalamin, Pregabalin, Orofacial Neuropathic PainAbstract
Introduction: orofacial neuropathic pain is extraordinary disease in character with its complicated management. Mecobalamin has been used to provide regeneration of traumatized nerves. Pregabalin with its analgesic activities relieves the clinical signs of neuropathic pain. The aim of this case report is to explain fixed dose combination of Mecobalamin and Pregabalin as the treatment of neuropathic pain caused by inferior alveolar nerve and facial nerve neuropathy.
Case: First case was an inferior alveolar nerve neuropathy experienced by 63 years old female with complaints of persistent pain and numbness around the left chin and left lower lip the day following the procedure of surgery for the treatment of dentoalveolar abscess on left second premolar of mandibula. Second case was facial nerve neuropathy experienced by 54 years old female had persistent pain and numbness of the anterior two-thirds of the tongue after total thyroidectomy and 1,100 MBq (30 mCi) activity of Radioactive iodine (RAI) therapy, followed with two 131I whole body scans.
Case Management: Mecobalamin 500 µg and Pregabalin 75 mg twice daily for 5 weeks were given with tolerable side effects and improvement symptoms.
Discussion: Pregabalin combined with Mecobalamin can reduce orofacial neuropathic pain. Pregabalin possess analgesic property and reduce neuropathy-related pain symptoms while Mecobalamin facilitates myelinogenesis and nerve regeneration.
Conclusion: Fixed Dose Combination of Mecobalamin and Pregabalin has the potential analgesic effect, reduced neuropathic orofacial pain at a below than determined dosage in case of inferior alveolar and facial nerve neuropathic pain.
Downloads
References
Shinoda M, Imamura Y, Hayashi Y, et al. Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies. Front Mol Neurosci. 2021;14(July):1-9. doi:10.3389/fnmol.2021.691396
Shrivastava M, Ye L. A Review on Autophagy in Orofacial Neuropathic Pain. Cells. 2022;11(23):1-18. doi:10.3390/cells11233842
Diamond-Rossi SA, Jonklaas J, Jensen RE, et al. Looking under the hood of “the Cadillac of cancers:” radioactive iodine-related craniofacial side effects among patients with thyroid cancer. J Cancer Surviv. 2020;14(6):847-857. doi:10.1007/s11764-020-00897-5
Vasudevan D, Naik MM, Mukaddam QI. Efficacy and safety of methylcobalamin, alpha lipoic acid and pregabalin combination versus pregabalin monotherapy in improving pain and nerve conduction velocity in type 2 diabetes associated impaired peripheral neuropathic condition. [MAINTAIN]: Results. Ann Indian Acad Neurol. 2014;17(1):19-24. doi:10.4103/0972-2327.128535
Häggman-Henrikson B, Liv P, Ilgunas A, et al. Increasing gender differences in the prevalence and chronification of orofacial pain in the population. Pain. 2020;161(8):1768-1775. doi:10.1097/j.pain.0000000000001872
Baad-Hansen L, Benoliel R. Neuropathic orofacial pain: Facts and fiction. Cephalalgia. 2017;37(7):670-679. doi:10.1177/0333102417706310
Shadmehr E, Shekarchizade N. Endodontic periapical lesion-induced mental nerve paresthesia. Dent Res J. 2015;12(2):1-5.
Avram AM, Zukotynski K, Nadel HR, Giovanella L. Management of Differentiated Thyroid Cancer: The Standard of Care. J Nucl Med. 2022;63(2):189-195. doi:10.2967/JNUMED.121.262402
Jeon EJ, Jung ED. Diagnostic whole-body scan may not be necessary for intermediate-risk patients with differentiated thyroid cancer after low-dose (30 mCi) radioactive iodide ablation. Endocrinol Metab. 2014;29(1):33-39. doi:10.3803/EnM.2014.29.1.33
Riachy R, Ghazal N, Haidar MB, Elamine A, Nasrallah MP. Early Sialadenitis after Radioactive Iodine Therapy for Differentiated Thyroid Cancer: Prevalence and Predictors. Int J Endocrinol. 2020;2020:1-8. doi:10.1155/2020/8649794
Jha A, Siddalingappa K, Herakal K, Malhotra K. Randomized Study to Compare the Effect of Pregabalin with Fixed-Drug Combination of Pregabalin and Methylcobalamin in the Patients of Postherpetic Neuralgia. Indian J Pain. 2018;32(2):63-67. doi:10.4103/ijpn.ijpn
Pino A, Parafioriti A, Caruso E, et al. What You Need to Know about Mental Nerve Surgical Anatomy for Transoral Thyroidectomy. J Endocr Surg. 2019;19(4):144-147. doi:10.16956/jes.2019.19.4.144
Sheikhi M, Kheir MK. CBCT Assessment of Mental Foramen Position Relative to Anatomical Landmarks. Int J Dent. 2016;2016:2010-2014. doi:10.1155/2016/5821048
Elahi F, Manolitsis N, Ranganath YS, Reddy C. Mental nerve neuropathy 2014;17;E375-E380. Pain Physician 2014;. 2014;17:375-380.
Doneddu PE, Pensato U, Iorfida A, et al. Neuropathic Pain in the Emergency Setting: Diagnosis and Management. J Clin Med. 2023;12(18):1-20. doi:10.3390/jcm12186028
Leung YY. Management and prevention of third molar surgery-related trigeminal nerve injury: Time for a rethink. J Korean Assoc Oral Maxillofac Surg. 2019;45(5):233-240. doi:10.5125/jkaoms.2019.45.5.233
Ciarallo A, Rivera J. Radioactive iodine therapy in differentiated thyroid cancer: 2020 update. Am J Roentgenol. 2020;215(2):285-291. doi:10.2214/AJR.19.22626
Stanciu AE, Hurduc A, Stanciu MM, et al. Portrait of the Inflammatory Response to Radioiodine Therapy in Female Patients with Differentiated Thyroid Cancer with/without Type 2 Diabetes Mellitus. Cancers (Basel). 2023;15(15). doi:10.3390/cancers15153793
Doo AR, Shin YS, Yoo S, Park JK. Radiation-induced neuropathic pain successfully treated with systemic lidocaine administration. J Pain Res. 2018;11:545-548. doi:10.2147/JPR.S155070
Nuszkiewicz J, Woźniak A, Szewczyk-Golec K. Ionizing radiation as a source of oxidative stress—the protective role of melatonin and vitamin d. Int J Mol Sci. 2020;21(16):1-22. doi:10.3390/ijms21165804
Dussor G, Boyd JT, Akopian AN. Pituitary hormones and orofacial pain. Front Integr Neurosci. 2018;12(October):1-15. doi:10.3389/fnint.2018.00042
Verma V, Singh N, Singh Jaggi A. Send Orders for Reprints to reprints@benthamscience.net Pregabalin in Neuropathic Pain: Evidences and Possible Mechanisms. Curr Neuropharmacol. 2014;12:44-56.
Lyon P, Strippoli V, Fang B, Cimmino L. B vitamins and one-carbon metabolism: Implications in human health and disease. Nutrients. 2020;12(9):1-24. doi:10.3390/nu12092867
Ghasemi S, Babaloo A, Sadighi M, Torab Z, Mohammadi H, Khodadust E. Effect of vitamin B complex administration on pain and sensory problems related to inferior alveolar nerve damage following mandibular implant placement surgery. J Adv Periodontol Implant Dent. 2022;14(1):13-19. doi:10.34172/japid.2022.007
Rahman M, Ferdoush KA, Jahan K, Masood S. Analgesic Effects of Vitamin B 12 : a Recent Update. J Glob Biosci. 2020;09(4):7160-7170.
Gazoni FM, Malezan WR, Santos FC. B complex vitamins for analgesic therapy. Rev Dor. 2016;17(1):52-56. doi:10.5935/1806-0013.20160013
Vyloppilli S, Thangavelu A, Vinod Vichattu S, Sayd S. Safety and Efficacy of Methylcobalamin in the Treatment of Peripheral Nerve Injuries and Diabetic Neuropathies - A Systematic Review. Acta Sci Pharm Sci. 2021;5(8):75-80. doi:10.31080/asps.2021.05.0769
Onysko M, Legerski P, Potthoff J, Erlandson M. Targeting neuropathic pain: Consider these alternatives. J Fam Pract. 2015;64(8):470-475.
SY ECN, Atakla HG, Mbaye M, et al. Pregabalin and mecobalamin combination in the management of refractory neuropathic pain: a potential alternative to early surgery in disco-radicular conflicts. Pan Arab J Neurosurg. 2023;18(1):69-71. doi:10.21608/pajn.2023.190195.1087
Jaya MKA, Dwicandra NMO. Effectivity analysis of neuroprotector (Vitamin B complex and mecobalamin) as neuropathic pain supportive therapy in elderly with type 2 diabetes mellitus. Asian J Pharm Clin Res. 2017;10(12):320-323. doi:10.22159/ajpcr.2017.v10i12.21845
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Manuel Dwiyanto Hardjo Lugito
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
- Every manuscript submitted to must observe the policy and terms set by the Interdental Jurnal Kedokteran Gigi (IJKG)
- Publication rights to manuscript content published by the Interdental Jurnal Kedokteran Gigi (IJKG) is owned by the journal with the consent and approval of the author(s) concerned.
- Full texts of electronically published manuscripts can be accessed free of charge and used according to the license shown below.
