THE EFFECTIVENESS OF PLATELET RICH FIBRIN, CONNECTIVE TISSUE GRAFT AND THEIR COMBINATION IN THE CLOSURE OF GINGIVAL RECESSION: A SYSTEMATIC REVIEW

Authors

  • Dian Anggraini Specialist Program Periodonsia, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia
  • Irma Ervina Department of Periodontia, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia
  • Aini Hariyani Nasution Department of Periodontia, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.46862/interdental.v20i1.7866

Keywords:

Connective Tissue Graft,, Platelet Rich Fibrin, Resesi Gingiva

Abstract

Introduction: Connective Tissue Graft (CTG) is one of the techniques in gingival recession treatment, but considering the morbidity of using CTG, biomaterials such as Platelet Rich Fibrin (PRF) can be an alternative in gingival recession closure treatment. This systematic review aims to compare and evaluate the use of PRF, CTG and their combination in gingival recession closure.

Review: An electronic literature search in Medline (PubMed), Google Scholar, and Elsevier (Sciencedirect) was conducted to identify Randomized Clinical Trial (RCT) reporting on the treatment of gingival recession using PRF, CTG or a combination of both from 2018 to 2023 in English. This systematic review was conducted following the Preferred Reporting Items for Systematic review (PRISMA) guidelines. The parameters assessed in the RCTs were: recession depth (RD), clinical attachment level (CAL), keratinized gingival width and height (KTW, KTH), probing depth (PD), gingival thickness (GT) and patient discomfort after surgery assessed by VAS (Visual Analog Scale). Based on the 1,152 articles retrieved, there were only five RCTs eligible for systematic review. Four articles compared the use of PRF with CTG, and one article compared the use of CTG with the combination of CTG + PRF in gingival recession closure.

Conclusion: The use of PRF, CTG, and a combination of both were effective in closing gingival recession. The use of CTG gave better results in increasing gingival thickness and keratinized gingival width compared to the use of PRF, but the combination of CTG and PRF gave significant results in keratinized gingival height and decreasing recession depth compared to the use of CTG alone. Thus, the combination of CTG and PRF may be a more promising gingival recession closure treatment option.

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References

Cortellini P, Bissada NF. Mucogingival conditions in the natural dentition: Narrative review, case definitions, and diagnostic considerations. J Clin Periodontol 2018;45:S190-S198. Doi:10.1111/jcpe.12948

Sameera S, Nagasri M, Aravind Kumar P, Indeevar P, Raviraj K, Musalaiah SVVS. Comparison of two surgical techniques in the treatment of multiple gingival recessions sandwiched with a combination of A-PRF and L-PRF. Saudi Dent J 2018;30(3):183-189. Doi:10.1016/j.sdentj.2018.03.002

Shivakumar MA, Gopal SV, Govindaraju P, Ramayya S, Bennadi D, Mruthyuenjaya RK. Evaluation of treatment for isolated bilateral miller’s class i or II gingival recession with platelet rich fibrin membrane- A comparative study. J Young Pharm 2016;8(3):206-213. Doi:10.5530/jyp.2016.3.7

Garg S, Arora SA, Chhina S, Singh P. Multiple gingival recession coverage treated with vestibular incision subperiosteal tunnel access approach with or without platelet-rich fibrin-A case series. Contemp Clin Dent 2017;8(3):464-468. Doi:10.4103/ccd.ccd_142_17

Balčiūnaitė A, Rusilas H, Žilinskas J. Use of platelet-rich fibrin versus connective tissue graft in treatment of gingival recessions: Literature review. Stomatologija, Baltic Dental and Maxillofacial Journal 2020; 22(2): 58-64.

Collins JR, Cruz A, Concepción E, López C, Hou W, Romanos GE. Connective tissue graft vs platelet-rich fibrin in the treatment of gingival recessions: a randomized split-mouth case series. J Contemp Dent Pract 2021;22(4):327-334.

Eren G, Kantarcı A, Sculean A, Atilla G. Vascularization after treatment of gingival recession defects with platelet-rich fibrin or connective tissue graft. Clin Oral Investig 2016;20(8):2045-2053. Doi:10.1007/s00784-015-1697-8

İşler SÇ, Uraz A, Şengül J, Çakıroğlu M, Bakırarar B, Çetiner D. Evalution of the patiens oral health related quality of life after harvesting free gingival graft Serbest dişeti grefti uygulanan hastalarin ağiz sağliği ile Ilişkili yaşam. avesis.ankara.edu.tr 2019;22(1). doi:10.7126/cumudj.452909

Tavakoli M, Zavare FG, Sajedi Z, Khodaei MH, Behdarvandi M, Ghalesefid FS, Yaghini J. Comparison of Coronally Advanced Flap Technique with Application of Free Connective Tissue or Platelet-Rich Fibrin. NVEO Journal 2021;8(5):6919-6927 doi:10.7759/cureus.35761

Ucak Turer O, Ozcan M, Alkaya B, Surmeli S, Seydaoglu G, Haytac MC. Clinical evaluation of injectable platelet-rich fibrin with connective tissue graft for the treatment of deep gingival recession defects: A controlled randomized clinical trial. J Clin Periodontol 2020;47(1):72-80. doi:10.1111/JCPE.13193

Modaressi M, Wang HL. Tunneling procedure for root coverage using acellular dermal matrix: a case series. Int J Periodontics Restorative Dent 2009;29(4):395-403.

Molnár B, Aroca S, Keglevich T, et al. Treatment of multiple adjacent Miller Class I and II gingival recessions with collagen matrix and the modified coronally advanced tunnel technique. Quintessence Int 2013;44(1):17-24. doi:10.3290/j.qi.a28739

Mancini L, Tarallo F, Quinzi V, Fratini A, Medicina SM. Platelet-rich fibrin in single and multiple coronally advanced flap for type 1 recession: An updated systematic review and meta-analysis. Medicina (Kaunas) 2021;57(2):144. Doi: https://doi.org/10.3390/medicina57020144

Culhaoglu R, Taner L, Guler B. Evaluation of the effect of dose-dependent platelet-rich fibrin membrane on treatment of gingival recession: a randomized, controlled clinical trial. J Appl Oral Sci 2018;26: e20170278. Doi: https://doi.org/10.1590/1678-7757-2017-0278

Mohan S, Jaishangar N, Devy S, Narayanan A, Cherian D, Madhavan S. Platelet-rich plasma and platelet-rich fibrin in periodontal regeneration: A review. J Pharm Bioallied Sci 2019;11(6):S126-S130. Doi:10.4103/JPBS.JPBS_41_19

Feigin K, Shope B. Use of Platelet-Rich Plasma and Platelet-Rich Fibrin in Dentistry and Oral Surgery: Introduction and Review of the Literature. J Vet Dent 2019;36(2):109-123. Doi:10.1177/0898756419876057

Chandramohan N, of FFIJ, 2021 undefined. Use of ’The Prf Membrane’for Root Coverage Rescue. eprints.southarchive.com. 2021;4(4):171-178. Accessed July 10, 2023. http://eprints.southarchive.com/id/eprint/219/

Tadepalli A, Chekurthi S, Kavassery Balasubramanian S, Parthasarathy H, Ponnaiyan D. Comparative Evaluation of Clinical Efficacy of Leukocyte-Rich Platelet-Rich Fibrin with Advanced Platelet-Rich Fibrin in Management of Gingival Recession Defects: A Randomized Controlled Trial. Med Princ Pract 2022;31(4):376-383. Doi:10.1159/000525560

Uraz A, Sezgin Y, Yalim M, Taner IL, Cetiner D. Comparative evaluation of platelet-rich fibrin membrane and connective tissue graft in the treatment of multiple adjacent recession defects: A clinical study. J Dent Sci 2015;10(1):36-45. Doi:10.1016/j.jds.2012.10.010

Methley AM, Campbell S, Chew-Graham C, McNally R, Cheraghi-Sohi S. PICO, PICOS and SPIDER: A comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews. BMC Health Serv Res 2014;14(1). Doi:10.1186/s12913-014-0579-0

Garzon H, Alfonso C, Vega F, Garcia A, Munoz A, Jaimes G, Isaza K, Rivera K. Treatment of miller I mandibular gingival recessions using PRF vs. connective graft. International Journal of Dentistry 2021;2021(6616688):1-6.

Eren G, Atilla G. Platelet-rich fibrin in the treatment of localized gingival recessions: a split-mouth randomized clinical trial. Clin Oral Investig 2014;18(8):1941-1948. Doi:10.1007/s00784-013-1170-5

Mummolo S, Mancini L, Quinzi V, D’Aquino R, Marzo G, Marchetti E. Rigenera® autologous micrografts in oral regeneration: Clinical, histological, and radiographical evaluations. Appl Sci 2020;10(15). Doi:10.3390/app10155084

Sundaresan P, Paramashivaiah R, Prabhuji MLV, Aswani C. Platelet Rich Fibrin: The “Wonder Bio-Material” To Enhance Recession Coverage with Lateral Pedicle Flap. Int J Res 2021;8(6):178-196.

Alan R, Ercan E, Firatli Y, Firatli E, Tunali M. Innovative i-PRF semisurgical method for gingival augmentation and root coverage in thin periodontal phenotypes: A preliminary study. Quintessence Int 2023;54(9):734-743. Doi: https://doi.org/10.3290/j.qi.b4328831.

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Published

2024-04-21

How to Cite

1.
Anggraini D, Ervina I, Nasution AH. THE EFFECTIVENESS OF PLATELET RICH FIBRIN, CONNECTIVE TISSUE GRAFT AND THEIR COMBINATION IN THE CLOSURE OF GINGIVAL RECESSION: A SYSTEMATIC REVIEW. interdental [Internet]. 2024 Apr. 21 [cited 2024 May 4];20(1):67-75. Available from: https://e-journal.unmas.ac.id/index.php/interdental/article/view/7866

Issue

Vol. 20 No. 1 (2024): Interdental Jurnal Kedokteran Gigi (IJKG)

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Copyright (c) 2024 Dian Anggraini, Irma Ervina, Aini Hariyani Nasution

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