EFEKTIVITAS SALEP EKSTRAK RIMPANG BANGLE (Zingiber purpureum Roxb) TERHADAP KEPADATAN KOLAGEN PADA PROSES PENYEMBUHAN LUKA PENCABUTAN GIGI MARMUT (Cavia Cobaya).
Kata Kunci:
Ointment, Bangle Rhizome, Collagen, Guinea PigAbstrak
Introduction: A wound is a failure of tissue components to unite. After tooth extraction, a wound or hole will result which is called a socket. When a wound occurs, it is followed by a wound healing process. Wound healing can be healed with modern and traditional treatment. Traditional medicine is still the people's main choice because of its low side effects and cheap price by utilizing natural resources, namely plants in the surrounding environment. One of the plants that has the potential to be used as medicine is Bangle Rhizome (Zingiber purpureum Roxb.). Bangle rhizomes contain active ingredients such as tannins, saponins, and essential oils which have the potential to act as anti- inflammatory, inhibit cell damage, and speed up the healing process in wounds. Purpose: The aim of this study was to test the effectiveness of bangle rhizome extract ointment in the healing process of tooth extraction wounds by observing collagen density in guinea pigs. Bangle rhizome extract ointment is made using the maceration method and then the ointment is made. Methods: This research is a laboratory experimental study carried out in vivo. In this study there were 24 samples divided into 4 groups. Each group consisted of 6 guinea pigs by making tooth extraction wounds and then treated on group I, namely Bangle rhizome extract ointment with a concentration of 80%, group II, namely Bangle rhizome extract ointment with a concentration of 85%, group III, namely Bangle rhizome extract ointment with a concentration of 90%. , and the negative control group, namely cera alba base ointment and petroleum jelly twice every day. On the 7th day after treatment, decapitation was carried out, specimens were taken to observe collagen density. The research data were analyzed using one way ANOVA followed by the Least Significant Difference (LSD) test. Results: The results of the study showed that administering bangle rhizome extract ointment (Zingiber purpureum Roxb) with concentrations of 80%, 85% and 90% was effective in increasing collagen density in the healing process of guinea pig (Cavia Cobaya) tooth extraction wounds.). Conclusion: The conclusion of this research is that administering bangle rhizome extract ointment with a concentration of 85% is more effective in increasing collagen density in the healing process of tooth extraction wounds in guinea pigs than concentrations of 80% and 90%.
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